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iheartsapphics · 2 years

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Mi Anhelo Por Ti

julieta madrigal x fem!reader

tw: topics and scenes of physical abuse

the sounds of wet mud and breaking twigs beneath your feet seemed to be muted by your increased heartbeat. the stinging pain that arose in your ankles only increased, but that didn’t stop you from running how you have been for almost a day. it looked like you just came from war. dirt covered your body along with dried blood and bruises.

“i have to keep going,” you thought to yourself.

you were unfamiliar with your surroundings and extremely tired. the heavy bag you carried only added to the exhaustion. this is the moment you’ve been waiting for. the second you stepped out of that house had felt like a weight was lifted off of your chest. your now ex-husband would miss you, but you sure as hell wouldn’t miss him.

you saw a large structure in the distance between the trees with lights. where there’s lights, there’s people, where there’s people, there’s-

“a town?”

you began to slow down in an attempt to catch your breath. the sun had been almost fully submerged by the darkness and you knew you couldn’t stay the night in the forest again. thankfully, the structure you saw wasn’t too far of a walk.

as you exited the forest, you were welcomed by many bright lights and colorful buildings. the people seemed to be busy with their own thing, some selling food and clothes. the aroma of arepas and various other foods filled your nose. you were so caught up in running you didn’t realize you were hungry.

then you realized all of it. the pain in your ankles, the blood running down from your lip down your neck, the screaming headache and urge to pass out. and that’s exactly what happened. you’d been running for so long nonstop without any source of energy- of course you’d pass out.

———————————————————————

“ay, isa! go check if the arepas are done warming up.”

you’d woken up to a sort of warmth and someone touching you. your eyes could hardly open, but when they did the first thing you saw was a beautiful woman above you. she seemed surprised that you’d woken up but continued what she was doing.

you winced as the warm, damp cloth gently rubbed against your wounds. your bruises ached and you felt sick. the other seemed worried from the wincing and put down the cloth.

“are you okay, hon?”

“where am i?”

noticing you were laid on a bed, you sat up carefully and looked around. the room was painted with little animals and the alphabet, along with what seemed to be different types of fabric laying around. a couple candles were lit on a nightstand by the door to give some light.

“i suppose you deserve an explanation. this town is Encanto. i’m julieta madrigal, and you’re in the madrigal house.”

a confused expression formed on your face.

“are.. you not from here?”

“lo siento, no. i arrived from a couple towns over. i’m y/n y/l/n.”

the older woman appeared to be surprised. she took a guess what was town you were talking about and had no idea why you would leave. she realized it wasn’t exactly her place to know, and then someone else walked into the room.

an obvious younger girl who looked to be in her twenties. she carried a plate with multiple arepas and handed it to julieta.

“thank you isa.”

“no problem, mama.”

the girl examined you with an intrigued expression on her face. she was dressed with a flower dress and her hair was beautifully done. she left the room to let her mother continue what she was doing with a sigh.

“who was that?”

“that’s my daughter, isabela. she’s actually the one who found you lying on the road.”

you suddenly remembered what had happened. you ran away from..him, and ended up here in Encanto. it was such a tiring journey due to all the running and adrenaline from escaping.

your stomach made several noises as you held it in embarrassment. julieta formed a smile and let out a slight chuckle, putting an arepa up to your lips.

“here, eat it.”

you took a bite and a burst of flavor entered you mouth. you quickly finished the arepa as you watched your several wounds heal. what was this? magic? it was something you didn’t know about due to being closed off for so long. you didn’t question it since the relief of feeling better washed over you.

you suddenly took the woman’s hand in yours which caused her eyes to widen a bit, a soft pink blush covered her cheeks.

“gracias. i really appreciate your kindness.”

“ah, it’s nothing. i do this on the daily.”

a deep voice called julieta’s name. it sounded angered and stern, causing her to jump. with her hand still attached to yours she squeezed it gently. it was a habit of hers when nervous.

“i’m sorry- i’ve got a few things to take care of tonight. mama said earlier you’re able to stay the night and we’ll continue with what to do in the morning.”

she got up, brushing off her dress. you took this as an opportunity to examine her better. she had glowing tan-skin and her figure was fairly average. you could tell she was shorter than most and the way she walked was elegant. she made her way to the door and spoke before closing it.

“welcome to encanto.”

the door closed and you were left on the bed with the few arepas still on the plate. you quickly finished them as you let out a sigh laying back down. you were very tired and relieved to finally feel a bed beneath you. you closed your eyes and began to fall asleep.

#julieta madrigal #julieta x reader #julieta x fem!reader #julieta encanto #encanto #julieta fanfic #encanto fanfic #x reader #julieta madrigal x reader #encanto imagine #julieta madrigal imagine #mapt #mi anhelo por ti #julietas wife material

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ecoamerica · 23 days

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youtube

Watch the American Climate Leadership Awards 2024 now: https://youtu.be/bWiW4Rp8vF0?feature=shared

The American Climate Leadership Awards 2024 broadcast recording is now available on ecoAmerica's YouTube channel for viewers to be inspired by active climate leaders. Watch to find out which finalist received the $50,000 grand prize! Hosted by Vanessa Hauc and featuring Bill McKibben and Katharine Hayhoe!

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cyber-sec · 7 months

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Researchers Link DragonEgg Android Spyware to LightSpy iOS Surveillanceware

Source: https://thehackernews.com/2023/10/researchers-link-dragonegg-android.html

More info: https://www.threatfabric.com/blogs/lightspy-mapt-mobile-payment-system-attack

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matthewklieger · 20 days

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Preserving Prosperity: Harnessing Trusts for Medicaid Planning Success

Medicaid is a cornerstone of healthcare assistance for individuals and families with limited financial resources. Yet, the labyrinthine eligibility criteria of Medicaid often pose daunting challenges, especially for those with substantial assets. Medicaid planning emerges as a crucial strategy, allowing individuals to navigate these complexities while safeguarding their wealth. At its core, Medicaid planning seeks to strike a delicate balance between accessing vital healthcare services and preserving financial prosperity.

The Imperative of Asset Preservation

Asset preservation lies at the heart of Medicaid planning. Exhausting their savings or liquidating assets to qualify for Medicaid benefits looms ominously for many individuals. However, thoughtful planning makes it possible to structure assets strategically, maintaining Medicaid eligibility while safeguarding wealth for future generations. The goal is to mitigate the risk of financial depletion due to medical expenses or long-term care costs.

Trusts: A Strategic Shield for Wealth Protection

Trusts emerge as indispensable tools in Medicaid planning, offering a strategic means of shielding assets from eligibility calculations while allowing individuals to retain varying degrees of control over their wealth. Individuals effectively divest themselves of direct ownership by transferring assets into a trust, potentially reducing countable assets for Medicaid purposes. This strategic maneuver enables individuals to qualify for Medicaid benefits without compromising their financial security.

A Closer Look at Trust Varieties in Medicaid Planning

Various types of trusts are deployed in Medicaid planning to suit diverse needs and objectives:

Irrevocable Trusts: These trusts are commonly used in Medicaid planning, as assets transferred into an irrevocable trust are no longer considered the individual's property. While relinquishing direct control over assets, individuals may still receive income from the trust or designate beneficiaries for distributions.

Medicaid Asset Protection Trusts (MAPTs): MAPTs are specifically designed to safeguard assets while maintaining Medicaid eligibility. They allow individuals to transfer assets while retaining the right to receive income generated by those assets. However, individuals must adhere to a specified "look-back period" to qualify for Medicaid benefits.

Special Needs Trusts (SNTs): SNTs support individuals with disabilities while preserving Medicaid eligibility. These trusts enable individuals to set aside funds for disabled beneficiaries without jeopardizing access to means-tested programs.

Qualified Income Trusts (QITs): Also known as "Miller Trusts," QITs address Medicaid income eligibility requirements. In states with income limits, individuals may establish QITs to redirect excess income into the trust, thereby reducing countable income for Medicaid purposes.

Strategies for Maximizing Asset Protection

To optimize asset protection through trusts in Medicaid planning, several strategies are recommended:

Early Planning: Medicaid planning should ideally commence well before the need for long-term care. Proactive planning allows individuals to structure assets strategically and navigate eligibility requirements effectively.

Comprehensive Assessment: Individuals should thoroughly assess their financial situation and healthcare needs. Understanding goals and circumstances enables the development of tailored strategies prioritizing asset protection and Medicaid eligibility.

Professional Guidance: It is essential to collaborate with professionals specializing in elder law, estate planning, and financial advisory services. Attorneys and financial advisors provide trust structuring, legal compliance, and financial optimization expertise for long-term care needs.

Navigating Complexities and Legal Frameworks

In the realm of trust-based Medicaid planning, navigating complexities and legal frameworks is paramount:

State Variations: Medicaid rules and regulations vary by state, influencing the effectiveness of trusts in Medicaid planning. Individuals must familiarize themselves with state-specific guidelines and seek guidance from knowledgeable professionals.

Look-Back Periods: Medicaid imposes look-back periods during which asset transfers are scrutinized for eligibility. Individuals must plan strategically to ensure compliance with regulations and avoid penalties or disqualification from benefits.

Estate Recovery: Medicaid may seek reimbursement for long-term care expenses from an individual's estate. Trusts can help minimize estate recovery efforts, but individuals must understand the implications and plan accordingly.

The Crucial Role of Professional Expertise

Given the intricacies involved, collaborative professional expertise is indispensable in trust-centric Medicaid planning:

Legal Counsel: Attorneys specializing in elder law or estate planning provide essential guidance in trust structuring and legal compliance, safeguarding individuals' interests and ensuring adherence to regulations.

Financial Advisors: Financial advisors are pivotal in coordinating investment strategies with Medicaid eligibility requirements, optimizing financial resources for long-term care needs, and aligning trust planning with broader financial objectives.

In the ever-evolving landscape of healthcare and finance, Medicaid planning serves as a beacon of financial security for individuals and families. Trusts are pillars in this endeavor, offering a strategic pathway to preserve wealth, protect estates, and ensure access to vital healthcare services. Through proactive planning, collaborative expertise, and strategic decision-making, individuals can embrace financial security and peace of mind in their Medicaid planning endeavors. With their dynamic role in asset protection, trusts empower individuals to navigate complexities with resilience, ensuring prosperity for themselves and future generations.

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ezwinonlinecasinooa · 21 days

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ผลการแข่งขันล่าสุดของทีม Norwich City เป็นอย่างไร?

🎰🎲✨ รับ 17,000 บาท พร้อม 200 ฟรีสปิน และโบนัสแคร็บ เพื่อเล่นเกมคาสิโนด้วยการคลิกเพียงครั้งเดียว! ✨🎲🎰

ผลการแข่งขันล่าสุดของทีม Norwich City เป็นอย่างไร?

ทีม Norwich City ได้โชว์ฟอร์มที่น่าทึ่งในการแข่งขันล่าสุด ทีมนี้ได้ทำให้ชาวแฟนบอลตะวันออกต้องอยากดูมากขึ้น ในการพ่ายทำผม! Norwich City ทำงานอย่างหนักเมื่อพบแมนเชสเตอร์ 9-0 - เร็วววว เมื่อวันอาทิตย์ที่ผ่านมา ทีม Norwich City จะต้องพบกับ Manchester United เป็นเกมที่หนึ่งในลีก Priemier ในช่วงเวลาที่ผ่านมา ทีม Norwich City มีผลรอนด์ ลมหายใจของแพ้ทีม เรื่องของผ่านผ่านเขตโทษบ้านเสียลูดของ2-0! เมื่อวันบาร์ตี่ที่ผ่านมมว่า ทีม Norwich City ใช้บิสทรนนิ เยื่ยบ้าขอเ Invirid ค้นพบทางเท่าไปกับการทำยาขอความสามจบลูกเคลือ + ผลอางโด้ีำงดุ้ผ่าแขงะดูอดโรน Price ด้วยจิ parตูเรสฟินีย์, ในช่วงเวลาที่ผ่านมา ทีม Norwich City กำลังพยายามอย่างหนักเพื่อปรับปรุงฟอร์ม ของการชนะ หวังว่าทีมจะสามารถกลับมาเกากฟอร์มที่ดีของความสามจบ หลีกเลี่ยงภาว์การหวอลุ เค้าาของยองับบอล Wizards หลายหลายบอกจากบาดงุาบูตไม้บมีลุำว่าเท่าบิน้สักรเหช็ เต้างหี้เหีลวิอจ่!

ขณะที่การเล่นกับผู้เล่นคนมากมีเสน่ห์และสนุกสนานอยู่เสมอ แต่ก็มีเวลาที่คุณอาจต้องการเพลิดเพลินกับเกมในความเงียบๆ ด้วยการเล่นเดียวเดียวดาย การเล่นเกมคนเดียวไม่ได้หมายความว่าคุณต้องทำทุกสิ่งด้วยตัวเอง แต่สามารถให้ความสนใจและเตรียมการได้อย่างรอบคอบ นี่คือโอกาสที่ดีในการสำรวจโลกแห่งมหาสงครามที่ไม่ผ่องในเกมหรือการอยู่กับตัวเองในโลกที่มีเรื่องราวและปริศนาให้ค้นพบ

การเล่นคนเดียวสามารถช่วยให้คุณมีโอกาสในการพัฒนาทักษะส่วนตัว ความคิดสร้างสรรค์ และความจินตนาการได้ลอยไปพร้อมกับความสนุกสนาน เกมที่ออกแบบมาสำหรับผู้เล่นคนเดียวมักมีเนื้อหาที่ลึกซึ้งและซับซ้อน และทำให้คุณต้องการค้นพบเรื่องใหม่ๆ ในทุกระดับ

คุณอาจสามารถรู้จักกับตัวละครหรือโลกทางมิติที่คุณไม่เคยรู้จักมาก่อน ซึ่งสามารถทำให้ประสบการณ์เล่นเกมของคุณหลากหลายขึ้น และเพิ่มความหลากหลายในเกมส์ของคุณ ดังนั้น อย่าปล่อยให้โอกาสในการสำรวจโลกแห่งมหาสงครามในปีนี้ผ่านทางการเล่นคนเดียวเดียวดายไม่พ้น นอกจากนี้ยังสร้างและส่งต่อประสบการณ์ของคุณในโลกเสมือนจริงในสนุกสนานไม่รู้จบด้วยการเล่นคนเดียวเดียวจากบ้านบางทีด้วย

เพลิดเพลินกับการผจญภัยใหม่ในโลกเสมือนจริงและสร้างความสนุกสนานในการเล่นเกมคนเดียวอย่างงดงามกับ "ผู้เล่นคนน่าสเดียวเดียวดาย"ในวันที่

อัตราการทำประตัวคือ หนึ่งในปัจจัยสำคัญที่ช่วยสร้างสุขภาพที่ดีและสุขภาพจิตที่ดีให้กับร่างกายของเรา การออกกำลังกายอย่างสม่ำเสมอช่วยลดความเสี่ยงของโรคต่างๆ เช่น โรคหัวใจ ความดันโลหิตสูง และเบาหวาน นอกจากนี้ยังช่วยให้ร่างกายมีกล้ามเนื้อแข็งแรงและทนทานต่อการเจริญเติบโตขึ้นไปด้วย

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อีกหนึ่งทีมที่มีประวัติศาสตร์ยาวนานในวงการฟุตบอลอังกฤษก็คือ Norwich City ซึ่งเป็นทีมที่มีความสำคัญในการแข่งขันในลีกที่หลากหลาย ไม่ว่าจะเป็นในลีกอังกฤษ หรือแม้กระทั่งในแข่งขันระดับโลก

ภาพของทีม Norwich City นั้นมีเสน่ห์และความเป็นเอกลักษณ์ เนื่องจากสีเหลืองและเขียวที่เป็นสีแห่งเศรษฐกิจและลูกเต็ม ที่แสดงถึงความพร้อมจะต่อสู้และสร้างประวัติศาสตร์ยิ่งใหญ่ในวงการฟุตบอล

ทีม Norwich City ยังมีแฟนคลับที่ใหญ่และเชื่อมั่นในความสามารถของพวกเขาอย่างมาก ซึ่งเป็นไปได้เนื่องจากประสบการณ์และความสามารถของนักเตะที่มีคุณภาพที่สูง และโค้ชทีม Norwich City ที่มีองค์กรที่แข็งแกร่งเพื่อพัฒนาทีมให้ดียิ่งขึ้น

กับความห้ามใจและความพยายามอย่างไม่หยุดนิ่ง ทีม Norwich City จึงมีโอกาสในการแข่งขันในระดับสูงในการแข่งขันฟุตบอลอังกฤษ และเป็นทีมที่ทุ่มเทในการพัฒนาตนเองอยู่เสมอ

ด้วยความเชื่อมั่นและความมุ่งมั่น ทีม Norwich City จึงมีโอกาสที่จะเป็นหนึ่งในทีมที่ยิ่งใหญ่ในอนาคต และเพื่อสร้างชื่อเสียงอันยิ่งใหญ่ในวงการฟุตบอลโลกในอนาคตที่กำลังจะมาให้กำเนิด

ในการวิเคราะห์สถิติผลงาน เราสามารถใช้ข้อมูลทางสถิติเพื่อประเมินและวิเคราะห์ผลการทำงานของบุคคลหรือองค์กรต่าง ๆ อย่างรวดเร็วและมีประสิทธิภาพ การวิเคราะห์สถิติผลงานสามารถช่วยให้เรารับรู้ถึงความสามารถ ความแข็งแกร่ง และจุดเด่นของบุคลากร และช่วยในการตัดสินใจเพื่อพัฒนาทักษะและสมรรถนะของบุคลากรให้ดียิ่งขึ้น นอกจากนี้ การวิเคราะห์สถิติผลงานยังช่วยในการวางแผนก่อนการดำเนินการ เพื่อให้การทำงานเป็นไปอย่างเชื่อถือได้และมีประสิทธิภาพมากยิ่งขึ้น

ในการวิเคราะห์สถิติผลงาน สิ่งสำคัญที่ต้องพิจารณาคือการเก็บข้อมูลที่ถูกต้องและครบถ้วน การวิเคราะห์ต้องเน้นที่ข้อมูลที่มีความสำคัญและสอดคล้องกับวัตถุประสงค์การวิเคราะห์ นอกจากนี้ การใช้เทคโนโลยีที่ทันสมัยเพื่อช่วยในการวิเคราะห์สถิติผลงานก็เป็นสิ่งสำคัญอีกด้วย เช่น การใช้โปรแกรมคอมพิวเตอร์หรือซอฟต์แวร์สำเร็จรูปที่ช่วยให้การวิเคราะห์เป็นไปอย่างรวดเร็วและแม่นยำ

ด้วยการวิเคราะห์สถิติผลงานที่ถูกต้องและเชื่อถือได้ เราสามารถพัฒนาและเสริมสรรค์ผลงานของบุคคลหรือองค์กรให้ดียิ่งขึ้นได้อย่างมีประสิทธิภาพ การวิเคราะห์สถิติผลงานเป็นเครื่องมือที่สำคัญที่ช่วยให้เราเข้าใจและปรับปรุงผลการทำงานให้ให้ผลลัพธ์ที่ดีที่สุด

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rnomics · 1 month

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Biomolecules, Vol. 14, Pages 358: Exploring SVA Insertion Polymorphisms in Shaping Differential Gene Expressions in the Central Nervous System

Transposable elements (TEs) are repetitive elements which make up around 45% of the human genome. A class of TEs, known as SINE-VNTR-Alu (SVA), demonstrate the capacity to mobilise throughout the genome, resulting in SVA polymorphisms for their presence or absence within the population. Although studies have previously highlighted the involvement of TEs within neurodegenerative diseases, such as Parkinson’s disease and amyotrophic lateral sclerosis (ALS), the exact mechanism has yet to be identified. In this study, we used whole-genome sequencing and #RNA sequencing data of ALS patients and healthy controls from the New York Genome Centre ALS Consortium to elucidate the influence of reference SVA elements on gene expressions genome-wide within central nervous system (CNS) tissues. To investigate this, we applied a matrix expression quantitative trait loci analysis and demonstrate that reference SVA insertion polymorphisms can significantly modulate the expression of numerous genes, preferentially in the trans position and in a tissue-specific manner. We also highlight that SVAs significantly regulate mitochondrial genes as well as genes within the HLA and MAPT loci, previously associated within neurodegenerative diseases. In conclusion, this study continues to bring to light the effects of polymorphic SVAs on gene regulation and further highlights the importance of TEs within disease pathology. https://www.mdpi.com/2218-273X/14/3/358?utm_source=dlvr.it&utm_medium=tumblr

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gadgetsforusesblog · 11 months

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Protect your assets against nursing homes

SmartAsset: How a Medicaid Trust Protects Your Assets A Medicaid Asset Protection Trust (MAPT) can be helpful for estate planning if you believe you or your spouse will need long-term care at some point. By transferring assets to this type of trust, you can qualify for Medicaid to pay for long-term care while preserving your savings. If you don’t have long-term care insurance, consider adding a…

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myfeeds · 1 year

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Large genetic changes that contribute to dementia risk identified

Structural variants have been implicated in a variety of neurological disorders. Unlike more commonly studied mutations, which often affect one or a few DNA building blocks called nucleotides, structural variants represent at least 50 but often hundreds, or even thousands, of nucleotides at once, making them more challenging to study. “If you imagine that our entire genetic code is a book, a structural variant would be a paragraph, page, or even an entire chapter that has been removed, duplicated, or inserted in the wrong place,” said Sonja W. Scholz, M.D., Ph.D., investigator in the neurogenetics branch of NINDS and senior author of this study. By combining cutting-edge computer algorithms capable of mapping structural variations across the whole genome with machine learning, the research team analyzed whole-genome data from thousands of patient samples and several thousand unaffected controls. A previously unknown variant in the gene TCPN1 was found in samples from patients with LBD, a disease, that like Parkinson’s disease, is associated with abnormal deposits of the protein alpha-synuclein in the brain. This variant, in which more than 300 nucleotides are deleted from the gene, is associated with a higher risk for developing LBD. While this finding is new for LBD, TCPN1 is a known risk factor for Alzheimer’s disease, which could mean that this structural variant plays a role in the broader dementia population. “From a genetics standpoint, this is a very exciting finding,” said Dr. Scholz. “It provides a point of reference for cell biology and animal model studies and possibly down the road, a target for intervention.” By looking at a group of 50 genes implicated in inherited neurodegenerative diseases, the investigators were able to identify additional rare structural variants, including several that are known to cause disease. The analyses also identified two well-established risk factors for FTD changes in the C9orf72 and MAPT genes. These proof-of-concept findings bolstered the strength of the study’s new findings by demonstrating that the algorithms were properly working. Because reference maps for currently-available structural variants are limited, the researchers generated a catalog based on the data obtained in these analyses. The analysis code and all the raw data are now available to the scientific community for use in their studies. An interactive app also allows investigators to study their genes of interest and ask which variants are present in controls vs. LBD or FTD cases. The authors assert these resources may make complex genetic data more accessible to non-bioinformatics experts, which will accelerate the pace of discovery. “Research to unravel the intricate genetic architecture of neurodegenerative diseases is resulting in significant advances in scientific understanding,” said Bryan J. Traynor, M.D., Ph.D., senior investigator at NIA. “With each discovery, we shed light on the mechanisms behind neuronal cell death or dysfunction, paving the way for precision medicine to combat these debilitating and fatal disorders.” Researchers expect that the dataset will continue to grow as additional data are analyzed. This work was supported in part by the Intramural Research Program at NINDS and NIA.

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petnews2day · 1 year

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New Data Presented at AD/PD™ 2023 Show Biogen’s BIIB080 (MAPT ASO) Substantially Reduced Tau Protein Levels in Patients with Early-stage Alzheimer’s Disease

New Post has been published on https://petn.ws/P6Tac

New Data Presented at AD/PD™ 2023 Show Biogen’s BIIB080 (MAPT ASO) Substantially Reduced Tau Protein Levels in Patients with Early-stage Alzheimer’s Disease

Biogen Inc. The BIIB080 Phase 1b clinical study is the first to show a reduction of this magnitude in tau PET across brain regions Phase 1b Study of BIIB080 showed dose-dependent and sustained reduction of tau protein (CSF t-tau and p-tau181) in the cerebral spinal fluid (CSF) throughout the open-label long-term extension (LTE) Neurofibrillary tangles […]

See full article at https://petn.ws/P6Tac #PetFinancialNews

#Pet Financial News

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metodologica · 1 year

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Una dieta alta en grasas a largo plazo expande la cintura y encoge el cerebro

Una nueva investigación en ratones transgénicos muestra que los alimentos grasos no solo aumentan su cintura, sino que también causan estragos en su cerebro.

Un estudio internacional dirigido por los neurocientíficos de UniSA, el profesor Xin-Fu Zhou y la profesora asociada Larisa Bobrovskaya, estableció un vínculo claro entre los ratones alimentados con una dieta alta en grasas durante 30 semanas, lo que resultó en diabetes, y un deterioro posterior en sus capacidades cognitivas, incluido el desarrollo de ansiedad, depresión y empeoramiento de la enfermedad de Alzheimer.

Los ratones con una función cognitiva deteriorada también tenían más probabilidades de aumentar de peso debido al metabolismo deficiente causado por cambios en el cerebro.

Investigadores de Australia y China han publicado sus hallazgos en Metabolic Brain Disease .

La neurocientífica y bioquímica de UniSA , profesora asociada Larisa Bobrovskaya, dice que la investigación se suma al creciente cuerpo de evidencia que vincula la obesidad crónica y la diabetes con la enfermedad de Alzheimer, que se prevé que alcance los 100 millones de casos para 2050.

“La obesidad y la diabetes dañan el sistema nervioso central, lo que exacerba los trastornos psiquiátricos y el deterioro cognitivo. Lo demostramos en nuestro estudio con ratones”, dice Bobrovskaya.

En el estudio, los ratones fueron asignados al azar a una dieta estándar o alta en grasas durante 30 semanas, comenzando a las ocho semanas de edad. La ingesta de alimentos, el peso corporal y los niveles de glucosa fueron monitoreados en diferentes intervalos, junto con pruebas de tolerancia a la glucosa e insulina y disfunción cognitiva.

Los ratones con la dieta rica en grasas aumentaron mucho de peso, desarrollaron resistencia a la insulina y comenzaron a comportarse de manera anormal en comparación con los alimentados con una dieta estándar.

Los ratones genéticamente modificados con enfermedad de Alzheimer mostraron un deterioro significativo de la cognición y cambios patológicos en el cerebro mientras se alimentaban con una dieta rica en grasas.

“Las personas obesas tienen un 55% más de riesgo de desarrollar depresión, y la diabetes duplicará ese riesgo”, dice el profesor asociado Bobrovskaya.

“Nuestros hallazgos subrayan la importancia de abordar la epidemia mundial de obesidad. Es muy probable que una combinación de obesidad, edad y diabetes provoque una disminución de las capacidades cognitivas, la enfermedad de Alzheimer y otros trastornos de salud mental”.

Referencia:

Xiong, J., Deng, I., Kelliny, S. et al. Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice. Metab Brain Dis (2022). https://doi.org/10.1007/s11011-022-01029-x

#Ciencia #Salud #Salud mental

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msweebyness · 5 months

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DuPont School for Monstrous Youths- Missy Rutherford

*GASP* A HuMaN friend for Adrien?! The plot thickens! Meet the monsters’ second official human ally! @artzychic27 @imsparky2002

Species: Human

Appearance/Attire: Short and stocky, choppy chin-length dirty blonde hair with the tips dyed pink, purple and green (the colors of the monster activism group), Narrow hazel eyes, tanned Caucasian skin, chip in her top left front tooth, side teeth on bottom row are pointed. Black scrunchie that holds up half of her hair, beat-up pale blue denim jacket with rolled up sleeves and Monster Activism pins, hot pink t-shirt with MAPT logo decal on front, several wristbands for monster rights events, tattered black jeans, green combat boots with purple soles.

Bio: One of Adrien's first human friends, Missy assists him in founding his monster rights activism group, 'Monsters Are People Too' or MAPT. Fiery and outspoken, she has no problem calling anyone out for being a prejudiced asshole, and has been known to get physical with bigots from time to time. She is quite protective of her best friends, Jesse and Adrien, and won't let anyone hassle them for their support of the monster community. Missy also has a softer side that comes out when around her friends. Much of Missy's passion for helping monsters comes from the deep care she holds for her childhood friend, Ondine, who she would swim with during family trips to the beach.

Quotes:

"You want me to pull up the ratios for humans attacking monsters compared to the reverse? You won't like the results."

"GET THE FUCK OUT OF HERE, JACKASS-O-LANTERN!"

"Change takes time to happen, Adrien. What matters is that we're making progress!"

"If I have to deck these assholes to get them to shut up, I will."

"Don't worry, guys, no one's giving you a hard time as long as I'm here!"

"Ready to open the meeting, chief?"

She’ll punch out a MHS (Monster Harassment Sympathizer)! Leave your thoughts in the comments and reblogs!

#miraculous ladybug #school for monstrous youths #monster high au #missy rutherford #mlb oc #theater kid #human #monster activism group

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iheartsapphics · 2 years

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Mi Anhelo Por Ti (2)

julieta madrigal x fem!reader

tw: topics and scenes of abuse

“y/n! get back here!”

you bolted out of your home- at least what used to be your home. it was the house you grew up in with your parents. being able to call it home made you feel so safe, but santiago had to ruin that.

santiago hernandez. who you used to call the love of your life turned into your worst nightmare. the honeymoon phase had been the best, but you hung onto it too much. the places he used to kiss you would be covered in bruises and scratches. his loving touch turned dirty and you couldn’t take it any longer.

why were you back running from him? you were sure you had reached a different town and got taken care of by the so called madrigals.

“wake up,” you told yourself.

“wake up!”

“y/n, hon, wake up.”

a sudden grab of your shoulder was enough to make your surroundings morph back to the room you were left in. you jumped and sat up quickly, julieta stepping back carefully. you looked around and let out a sigh of relief.

“oh, y/n, i apologize for scaring you. i just came to wake you up to let you know breakfast will be ready soon.”

a warm smile formed on your face as you responded.

“it’s fine, just a startling dream was all.”

“may i ask what it was?”

you went quiet. you didn’t want to make her uncomfortable or share what had happened anyway. julieta was still a complete stranger, though you felt safe with her. how strange.

julieta grabbed the side of her dress as she felt the awkward tension rise. she didn’t mean to go too far. she came closer to you and placed a pair of clothes down on the bed. she didn’t want you to keep wearing the same ones you have been for the past few days.

“there’s a hot shower running the next room over. you can come down whenever.”

“gracias senora.”

she smiled and turned to exit the room. you noticed a few burn marks on her arm, must’ve been from cooking.

—————————————————————

the outfit julieta had given you was comfortable and fit pretty well. you were confused by the large house as you saw windows and floor tiles moving, but amazed at the same time. the front doors were open and you peeked outside to see a few others gathering food and sitting down.

everything seemed so in order, of course you felt out of place. these strangers took you in but why? you weren’t used to such kindness. eventually you figured out what foods were which and made your plate. julieta waved at you from the table and you went to sit next to her.

the table was filled with the rest of the madrigals. you only felt somewhat comfortable with julieta and isabela as they were the only ones introduced to you.

“julieta, where’s agustin?”

the older looking woman that sat at the end of the table asked. you looked at julieta and noticed her tense up a bit.

“oh, he left for work early. i already packed him some food last night.”

she smiled and continued eating her food. you began to eat as you let out a sigh. you hadn’t tasted food this good in forever, it was nice. you felt eyes on you and you knew it was the other people at the table.

from the time you sat there, you picked up on their names and magic they had. it was interesting and something new to you. camilo and isabela’s interactions were hilarious, and you absolutely loved little antonio. felix and pepa just seemed to be in their own world together. they spoke of bruno and claimed he had gone out to run a few errands. you then noticed luisa and dolores helping mirabel eat. you wondered what was wrong with the younger girl, but felt it wasn’t your place to ask.

you finished up your food as you saw the others leaving to attend their duties. julieta quickly sighed and began picking up the dishes. she looked very tired as you noticed the dark circles surrounding her eyes. you didn’t know what to do, and the least you could do is help her out.

you began picking up the empty plates as the other quickly noticed.

“y/n, it’s fine. i can do them on my own.”

that same warm smile she had last night appeared on her face. you found it cute but quickly shook your head “no” in response.

“i want to help, i’ve got nothing to do anyway.”

the older woman’s heartbeat slightly quickened. julieta could tell you were a stubborn one and knew there was no point in arguing with you. you gathered up the rest of the plates and followed her to the kitchen.

there was a comfortable silence between the both of you. the sink surprisingly wasn’t too big so you had to stand close together to wash the dishes. your shoulders touched and the warmth of your skin contacting with julieta’s made her shiver.

“your family is very interesting.”

you were the one to break the silence. julieta looked up at you for a couple seconds before setting her focus back to the plates.

“ha, yeah. my two other daughters were luisa and.. mirabel. i love them with all my heart.”

“your mother mentioned a man agustin. is he your husband?”

the shorter woman stopped scrubbing the plate then resumed quickly. her tone of voice had changed and she didn’t look up at you after that.

“y-yes.. he is. we’ve been married since our late twenties. he’s changed since the fall of casita, though.”

as you were about to ask another question, the older woman from earlier came into the kitchen. you both turned around and julieta quickly changed her expression. you waved and said a quiet “hola,” waiting to see her speak.

“hola, mama. me and y/n were just doing the dishes.”

“ah, y/n. call me alma. i’ve come to tell you that a few of the workers in town will be building you a house for you to live in. you’re very much welcomed and can stay in casita until the house is finished.”

you formed a smile and quickly wiped your hands to be able to take alma’s in yours.

“thank you so much, alma. i deeply appreciate it.”

alma smiled back and nodded. she was happy to be of help to you as she could tell you were a great person. she then left the kitchen and you went back to the sink only to see julieta finished the dishes.

“y/n.. if you’d like you could come into town with me to help out the citizens since you have nothing to do. i also prefer not to leave you alone here.”

“of course! i’d love to.”

you gently squeezed her shoulder and left to go gather your things. julieta stood there beginning to gather up the food she had cooked earlier.

she was confused with herself. you were still a stranger she just met last night. what was this sudden attraction to you? it was wrong. she loved agustin with everything she had, unless she’d been forcing herself to think that. you’ve shown her nothing but kindness. julieta stuck with thinking it was just the excitement of a new friend. she quickly ignored the thought as you came back down with your bag in hand.

there was just no way she could love anyone in that way except for agustin… could there?

#julieta madrigal #julieta x reader #julieta x fem!reader #julieta encanto #julieta madrigal encanto #julieta madrigal x reader #encanto #julieta madrigal fanfic #encanto fanfic #x reader #encanto imagine #julieta madrigal imagine #mapt #mi anhelo por ti #julietas wife material

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cfslegal · 1 year

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Choosing an Estate Lawyer

Choosing anestate lawyer Liverpoolcan be a very important decision. You need to make sure that you understand the role they play and that you have a will prepared and properly executed. A good estate lawyer can help you to understand how to leave your loved ones what they need when you are no longer able to provide for them. They can also help you to protect your assets from Medicaid.

Do you have a will?

Having a will can be a life changing decision for your beneficiaries. Having a will also avoids squabbles over small estates. Having a will will also help to ensure that your children are taken care of. A will is also a good way to provide for special needs children.

A will dictates the disposition of the estate after the death of the person making it. It appoints a personal representative and names guardians for minor children. It also explains the distribution of property. A will can be updated as often as needed.

A will can be written entirely in the person's own handwriting. It cannot be disputed in court. However, if you do not have a will, you may be subject to the intestacy laws of your state. These laws determine the distribution of assets and who gets them.

A will can be made as soon as you get married or start a family. It can also be updated as your circumstances change.

Can you contest a will?

Whether or not you can contest a will depends on several factors. The most important factor is whether you have a good reason for doing so. If you don't have a good reason for doing so, it's unlikely that you'll succeed in your claim.

A good reason for contesting a will would be to try and recover assets from the beneficiaries. However, this is difficult if the money has been spent on the estate. In some cases, the costs of litigation have been paid by the estate.

A will contest is also possible if you suspect that the will was made without adequate consideration. This can happen when a testator does not know how to make a will. It can also occur if a testator remarried just before their death. In this case, a new will would replace the older one.

The best way to contest a will is to consult a legal professional in the UK. They can help you decide whether or not you have a good claim and will be able to give you advice on the likelihood of your claim. You may need to make an appearance in court. This can be a costly process and may affect relationships with other family members.

Can an estate lawyer help you protect assets from Medicaid?

Whether you're looking to apply for Medicaid, or have already applied, you need to know how to protect your assets from the government. There are different strategies to do this, and some require advance planning. A good asset protection attorney can help you avoid penalties and reimbursements. They can also help you bypass outstanding nursing home bills.

If you have assets you want to protect from the government, you can put them in a trust. A trust is a legal document that a trustee (or settlor) creates that holds your assets and passes them on to your beneficiaries when you pass away. The trust can be revocable, irrevocable, or a combination of both. It can be used for any type of property.

You can protect your home from the government by placing it in a Medicaid Asset Protection Trust (MAPT). A MAPT is an irrevocable trust that protects your assets from being counted as Medicaid assets.

Can an estate lawyer help you navigate the process of leaving loved ones what they need?

Managing an estate can be a difficult task. In order to make the process easier, it is helpful to seek the advice of a lawyer.

A lawyer can help you decide who should receive what and can make sure the estate is properly distributed. A lawyer will also help you make sure your wishes are respected. If you have been wronged, an attorney can help you understand your rights.

An estate lawyer will also help you to identify assets, determine heirs, and handle important medical issues. If you are close to a relative who has recently passed away, you need to take basic steps quickly to ensure your loved one's legacy is kept intact.

You will need to contact the court to begin the process of probate. After the process is completed, your loved one's final bills will be paid. However, you will need to keep records of all of your loved one's expenses and debts. This will prevent the creditors from showing up and getting money from the estate.

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mooremacias · 1 year

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Cross design and style assessing brand-new biomarkers when there is a pre-existing screening process analyze.

Within this paper, we all produce an improved upon technique which improves the spatial exactness with the method simply by decreasing image-pair deformation blunders and its up coming use within the particular characterization of warmed up microchannels. In order to spatially adjust the actual image-pair and quantify the actual deformation of just one image with regards to the various other, chemical graphic velocimetry ended up being done along with sandpaper. Final results reveal that the objective contact lens along with the principal dichroic mirror won't significantly modify the column course and that the principle way to obtain distortion probably will take place between your second dichroic reflection as well as the indicative and decorative mirrors within the release splitting technique. This kind of spatial calibration and relationship strategy was adopted to be able to guide the particular temperatures submitting in microheated microchannels. The actual experimentally determined advective performance final results confirmed good contract in opposition to their particular numerically calculated alternatives. These kinds of outcomes suggest that the power provided for the microheaters must be different keeping that in mind to maintain preset heat fluctuation circumstances over the microchannel partitions like a objective of movement price. [2014-0041]It has been noted in which some single-nucleotide polymorphisms (SNPs) are generally from the probability of Parkinson's disease (PD), but no matter whether a combination of these types of SNPs would have a stronger connection to PD when compared with anyone SNP is actually unknown. Sixteen SNPs located in the 8-10 family genes and/or loci (SNCA, LRRK2, MAPT, GBA, HLA-DR, BST1, PARK16, along with PARK17) had been analyzed within a Oriental cohort consisting of 1061 well-characterized PD patients along with 1066 control themes coming from Main Southern regarding Landmass The far east. We all found out that Rep1, rs356165, along with rs11931074 in SNCA gene; G2385R throughout LRRK2 gene; rs4698412 throughout BST1 gene; rs1564282 inside PARK17; as well as L444P inside GBA gene have been associated with PD with realignment associated with sexual intercourse and age group (r smaller than 2.05) within the examination of Sixteen variations. PD threat elevated whenever Rep1 as well as rs11931074, G2385R, rs1564282, rs4698412; rs11931074 along with G2385R, rs1564282, rs4698412; G2385R and also rs1564282, rs4698412; as well as rs1564282 and also rs4698412 had been put together to the association analysis. Additionally, PD chance improved cumulatively with all the raising quantity of versions (probabilities rate for carrying 3 variants, Three or more.494). In summary, many of us verified that will Rep1, rs356165, along with rs11931074 in SNCA gene, G2385R throughout LRRK2 gene, rs4698412 within BST1 gene, rs1564282 inside PARK17, and L444P throughout GBA gene provide an self-sufficient and mixed significant association with PD. SNPs in these Several family genes have a snowballing influence using PD. (C) 2015 Elsevier Inc. Almost all protection under the law set-aside.Within the Approval for usage of statins inside Elimination: a great Input Test Analyzing Rosuvastatin (JUPITER), arbitrary allowance of rosuvastatin compared to placebo between primary reduction individuals having a low-density lipoprotein cholestrerol levels a higher level <One hundred thirty SCH66336 datasheet mg/dl and a high-sensitivity C-reactive health proteins (hs-CRP) amount of >Is equal to Only two mg/L led to a highly significant 44% lowering of major vascular situations.

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