#trisomes

[uyvetmwlo]

FJK LANA Forced videos Trio hotwife primer encuentro Lily carter teen and sexy babe in threesome with facial first time Gay boy cute porn movies Kellan rolls Ryan over and as Ryan is now on Teen sucking old pervert August Taylor gets Fucked hard In Pussy Hole America teacher student gay porn stories xxx Jacques heads down on bluffs run rv park at horseshoe casino council bluffs iowa Footjob solejob

#ampharos #estafa #semmit #beshadowing #shmoozes #strangered #abos #Jamshedpur #degreeless #selenographer #trisomes #methomania #overpack #circumdate #stibbler #pedlary #well-kept #meningic #Tumion #riotistic

[t-as-pas-tort-dall-e]

#Dall E #Fortnite #drawn by #trisomic

[wandixx]

Justice League never helped Amity Park.

Why?

They genuinely didn't need any help, it was one of the most normal and safe town in America.

Other than Jack Fenton on the road hazard but it's not like he can break walls with his orange jeep, is it? It's too little to get JL on it.

Okay, so what does Phantom do right outside of the Watchtower drinking Capri sun? Is it related to how horrified Flash is, running around meeting room like he tries to wear down the floor?

Why yes, absolutely. You see dear traveler, Ghost child is just not from this timeline.

He is from the other one. The intense one. The one, where Amazonians were at war with Atlanteans, where there was no line Batman wouldn't cross, where doctors Fenton didn't stop their research after their dearest friend had accident.

Yeah, that's the one. One that Barry created by saving his mother and the one he allegedly destroyed.

How do they tell the stressed ghost child that timeline he lived in ceased to exist?

*~*~*

Maybe I'm not clear enough but yeah. Phantom is from other timeline but as I heard, Dan shoved time medalion into Danny's chest so now our boi has wonky relationship with time. When Barry erased "wrong timeline", Danny got yote into his time and was confused. Like, one day he wakes up in the middle of the nowhere because of some shit and isn't even surprised at first but then realises something is off. Especially when he gets to the nearest town. Things are all sorts of wrong, like:

There is less ambient ectoplasm in the air.

Meme references are just not right.

There is no supernatural war.

Nobody is trying to post mortem murder him for being a ghost.

There are a lot more heroes and the ones he knew are different, like, why is Batman suddenly so much against killing?

So he goes of to find Amity and see which one's of the ghosts bullshit he has to clean up this time, only to see his city... Normal? Happy even? No broken pavements or anti ghost tech? No teenage stans? No alive food? His parents are more of the local handymen than mad scientists?! There is SECOND HIM, who isn't a ghost in the slightest?!

WHAT THE FUCK JUST HAPPENED AND HOW DOES HE FIX IT?!

Because yeah, this world seems nicer than real one, but he just can't stay here. Ghosts are probably wrecking havoc in his Amity again and he needs to get back now.

Just question is how, because it starts to look like whole new world and not some weird hallucination or Desiree doing her shit again. However so much things is similar that he assumes it's different timeline. He dealt with these before, once, but he managed. He just needed to find this Clockwork guy that showed up last time and learn what he has to do to fix it.

Wait, his parents here didn't made portal and Vlad didn't either because they're actually kind of trisome (ew) and he didn't have enough time. That's alright, Danny was raised in the shadow of the portal, he knew everything about it by heart. He could built it on his own.

Wait, portal needs and sacrifice. Can he use this world's himself as a sacrifice? He could probably ask these heroes for help but on the other hand he really doesn't want to do this to him. Being Phantom majorly sucks ass and he is jealous but he knows better than to destroy other his life over it.

Before he can resolve his dilemma, something he does pings Justice League's radar and Flash is send to investigate. Thank ancients it's him because allegedly other heroes wouldn't really get it. But it was Flash who somehow gets at least part of it, gives him a food and takes him to the space station (in space!). Now they have meeting about him and he has best view of stars he could ever imagine. Even though they're a little different than he remembers from back home.

.

Hope you enjoyed this little idea and maybe can add to the shenanigans. Comments and reblogs are whole yours.

I hope I'm englishing correctly and won't see too many spelling or grammatical mistakes when I wake up in the morning

Have a great whatever part of day it is to you

#dp x dc #dpxdc #dcxdp #dc x dp #time travel and different timeline shenanigans #danny is a little morally ambiguous in here #he actually considered half killing someone to get back home #because what would happen if he used himself as a halfa as a sacrifice? #would he die fully? #he can't afford it y'know #in his defense #his heroes aren't crystal clear either #he had no real role models #but he can have now #he is delighted when he learns there are aliens around #and they are mostly accepted #he didn't cry #shut up he didn't #but it feels good to now he won't be shot just for existing here #or at least not by everyone and not legally #:)

[finniestoncrane]

Not gonna be too original, my dream 3way team is Arkham Eddie x Scarecrow and me cosplaying Poison Ivy cause yeah, more greenery is good for everybody.

But Ivy x Ivys plants x me comes as second best.

As for a nightmerish trisome, I think Mr Freeze x Firefly wouldnt work too well, ya know, you hot then you're cold...

i get it i get it, a classic obviously!

and i am screaming beside you anon as a recent entrant into the tentacle lovers arena i am DOWN for ivy using her vines to do whatever the fuck she wants to me >:3c

BUT i don't think your nightmare is a nightmare!! i actually could get very down with that. the temperature play opportunities. the stinging pain, soothed by the other before it becomes the pain that needs to be soothed. just a constant back and forth of too cold ah just nice too hot ah just nice too cold ah just-

#friends being friends #anon

[orphee-aux-enfers]

Thank you for tagging me @corrode-in-repose this is fun!!

Rules: You can usually tell a lot about a person by the type of music they listen to. Put your playlist on shuffle and List the first 10 songs, and then tag 10 people. No skipping! 

Il Se Noie - Trisome 21

Wreck - Gentle Giant

You're Gonna Go Far, Kid - The Offspring

Broken Teeth - the Cemetary Girlz

The Louvre - Sparks

Pain - Three Days Grace

Violence Grows - The Fatal Microbes

Devil's Answer - Atomic Rooster

Spent the Day in Bed - Morrissey

Break Right In - Buzzard Buzzard Buzzard

Well, that is, in fact, as much of a mess as the folder I put on Shuffle is! The only one that I haven't listened to more than once in the last two months is Spent the Day in Bed, and I'm mildly embarrassed by this.

tagging, with zero obligation attached, I just know you all like music: @le-seraphin-aux-cieux @thesunhungfomastring @prongsisthesun @euphorial-docx

#music #tagged in #games

[indepwom101]

🇱🇺 Grand Duke Henri of Luxembourg

Monday, May 22, 2023

HRH The Grand Duke opened, this afternoon in Betzdorf, with Claude Haagen, Minister of Agriculture, Viticulture and Rural Development, the old barn "Al Scheier" and the new Place Grand Duke Jean, built in honor of the former sovereign and where are the major events that have marked the his life.

Under renovation since 2020, the nearly 150-year-old barn has been envisioned by citizens as a new place of living and meeting in which classes and training can be held.

On the social level, "Al Scheier" welcomes two associations: "Trisomy 21" and "Initiative Liewensufank". The first accompanies people with trisomics to give them as much autonomy as possible in their daily lives, while the second guides and informs future parents about the evolution of family life. Special attention was paid to the accessibility of the site for people with disabilities.

The Head of State warmly thanked the municipality and its citizens for this beautiful tribute full of solidarity and humanity.”

#grand ducal family of luxembourg #grand duke henri

[tiny-tigers]

Rough day...

No train to work this morning train delayed this afternoon...

One autistic tried to assault one of my trisomic while we were giving lessons it was a bit scary and I was so tired yesterday after fencing I had not the head to answer anything I am so sorry.

I am so sore and head full of what I must finish before friday, it is full rush as I have an exhibit on friday night to curate.

[notizieoggi2023]

L'Italia con sindrome di down ancora sul tetto del mondo L’Italbasket con Sindrome di Down è inarrestabile e si laurea campione del mondo per la quarta volta nella sua storia. Battuta in finale la Turchia padrone di casa per 18-17. In una partita tiratissima, dall’inizio alla fine (parziali: 3-5; 6-2; 3-3; 6-7) i nostri ragazzi sono riusciti nell’impresa di vincere l’ultimo trofeo che mancava in bacheca: proprio il successo ai Trisome Games, la competizione mondiale per atleti con Sindrome di Down. Sono ora 4 le manifestazioni mondiali e 2 europee nel palmarés azzurro, a cui si aggiunge la soddisfazione di veder premiato anche Davide Paulis come miglior giocatore del torneo. Ma dal capitano Alex Cesca a tutti gli altri giocatori (Andrea Durante, Stefano Barollo, Alessandro Greco, Emanuele Fiorini, Francesco Leocata Andrea Rebichini) è stato l’ennesimo capolavoro corale firmato dalla squadra del ct Giuliano Bufacchi che dopo il trionfo ha commentato: «Belissimo. Da anni con la Turchia le partite sono di altissimo livello perché il loro allenatore col quale siamo amici, lavora bene, come noi… Quindi la soddisfazione è maggiore quando batti un amico. La prossima volta vinceranno loro? Possibile. È il bello dello sport». Entusiasta anche il capo delegazione Gaspare Majelli: «I nostri ragazzi, anche sotto il tifo rovente dei padroni di casa, hanno mantenuto da veri campioni la giusta concentrazione che gli ha consentito di difendere il titolo mondiale». E complimenti anche da Luca Pancalli, presidente del Comitato italiano paralimpico: «Avete portato ancora una volta in alto il nome dell’Italia».

#youtube

[leedsomics]

Single-cell multi-omics map of human foetal blood in Down's Syndrome

Down's Syndrome (DS) predisposes individuals to haematological abnormalities, such as increased number of erythrocytes and leukaemia in a process that is initiated before birth and is not entirely understood. To understand dysregulated hematopoiesis in DS, we integrated single-cell transcriptomics of over 1.1 million cells with chromatin accessibility and spatial transcriptomics datasets using human foetal liver and bone marrow samples from three disomic and 15 trisomic foetuses. We found that differences in gene expression in DS were both cell type- and environment-dependent. Furthermore, we found multiple lines of evidence that DS haematopoietic stem cells (HSCs) are "primed" to differentiate. We subsequently established a DS-specific map of enhancer-gene relationships in disomic and trisomic HSCs using 10X Multiome data. By integrating this map with genetic variants associated with blood cell variation, we discovered that trisomy restructured enhancer-gene maps to dysregulate enhancer activity and gene expression critical to erythroid lineage differentiation. Further, as DS mutations display a signature of oxidative stress, we validated both increased mitochondrial mass and oxidative stress in DS, and observed that these mutations preferentially fell into regulatory regions of expressed genes in HSCs. Altogether, our single-cell, multi-omic resource provides a high-resolution molecular map of foetal haematopoiesis in Down's Syndrome and indicates significant enhancer-gene restructuring giving rise to co-occurring haematological conditions. http://dlvr.it/SwgGVb

[shitpostroundhouse]

Homeopathic erection, people!

Trisomic structure (WTF)

Keep scrotum dry (will do, hoss!)

Homeopathic erection,

...don't forget.

Single space clipping. *Extrusion clipping* Right, WTF? *Hygrophyte (What in the WTF?)

#homeopathic erection #that's right

[andreeemlr]

Down Syndrome:

“An insight of disease”

This is one of the commonest disorders and very expensive . Down Syndrome is associated with number of phenotypes. People that has Down Syndrome are affected by these phenotypes to a variable extent thus understanding the cause of this variation is a key challenge. The genes involved in Down syndrome associated Alzheimer’s disease, congenital heart defects, leukemia including, hypertension and Hirschprung disease are discussed here. Moreover, i have also reviewed various prenatal diagnostic method from karyotyping to rapid molecular methods noninvasive prenatal diagnosis in detail.

Down syndrome is one of the most leading causes of intellectual disability and millions of these patients face various health issues including learning and memory, congenital heart diseases, Alzheimer’s diseases, leukemia, cancers and Hirschprung disease. The incidence of trisomy is influenced by maternal age and differs in population. Down Syndrome has high genetic complexity and phenotype variability from 6 to 8. Trisomic fetuses are at elevated risk of miscarriages and Down Syndrome people have increased incidence of developing several medical conditions approx 9. Recent advancement in medical treatment with social support has increased the life expectancy for Down Syndrome population. In developed countries, the average life span for Down Syndrome population is 55 years.

Based on my experience I have a little cousin and he suffers DS and he is the sweetest boy I ever met is just I think there are things that are a little bit more difficult to them.

[ratliffjames]

Acyl CoA dehydrogenase and Its Restorative Prospective within the Treatment of Continual Lymphocytic Leukemia: A shorter Evaluate about Growing Files

Results: 50 Acyl CoA dehydrogenase families of carriers regarding GM, the location where the sexual intercourse with the offspring ended up given, were discovered from the books plus logbooks of a pair of nearby genetic devices. Moms during these people have been relatively younger: just 8% of mums ended up 35 years old along with more mature at the time of shipping and delivery of the first impacted offspring as the proportion regarding grandmothers around the Game master carrier's facet aged Thirty-five years and also elderly had been significantly higher (39%). Postzygotic relief regarding T21 because of error inside the meiosis I had been suggested like a procedure involving parent Game master development throughout 78% from the families together with acknowledged source from the T21. For that various other 22%, save of mistakes in the meiosis II or even postzygotic mitotic non-disjunction ended up being presumed. Mosaicism regarding T21 inside consecutive generations has been described in at least Twelve families. The particular amount involving mosaics amongst affected women kids (14%) is really a lot increased to this amongst impacted man young (0%). Men preponderance (SR Is equal to 1.A few) can be found in neo variety liveborn children using possibly maternally-or paternally carried T21. Amid unchanged young regarding man carriers involving GM there is a distinctive more than females (SR = Zero.27). Conclusion: Each immediate (outcomes of cytogenetic along with molecular research with the origin regarding trisomic collection) and also oblique (superior grandmaternal grow older along the side of Game master service provider) facts let assume that significant proportion in the variety mom and dad had been developed since trisomics. Female-specific trisomy recovery as well as anatomical frame of mind in order to postzygotic non-disjunction has been advised since systems involving development associated with each General motors and also somatic mosaicism. Common guy variety in influenced low variety offspring together with sometimes maternally-or paternally carried trisomy 21, signifies as compared to meiotic events aren't in charge of the particular manipulated intercourse rate within Nintendo ds. Nonetheless a lady extra amongst untouched children associated with men service providers of GM might be the selleck chemicals llc results of meiotic no homologous co-orientation associated with chromosomes 21 years old and also By inside spermatogenesis.Seeks and goals. This papers identifies when and exactly why tactical investigation can be used and also describes making use and model in the strategies most often came across in medical novels. This can be executed making use of good examples removed from key healthcare Cabozantinib manufacturer periodicals. History. Survival evaluation is actually widely used within clinical as well as epidemiological research: within randomised clinical trials pertaining to comparing your efficiency of therapies along with observational (non-randomised) study to discover and try out the information on epidemiological affiliation. Style. This particular paper presents the principles, exercise and language of success investigation.

#Cabozantinib #Remdesivir #Acyl CoA dehydrogenase

[miralwhiz]

El yate fajardo

Findings that increased cerebrospinal fluid levels of proNGF mark the onset of MCI and the transition to AD suggests that this proneurotrophin is a potential disease biomarker. In addition to neurotrophin dysfunction, studies indicate alterations in epigenetically regulated proteins occur within cholinotrophic nbM neurons during the progression of AD, suggesting a mechanism that may underlie changes in transcript expression. Despite these degenerative events the cholinotrophic system is capable of cellular resilience and/or plasticity during the prodromal and later stages of the disease. Data indicate a spatiotemporal pattern of degeneration related to the evolution of tau pathology within cholinotrophic neuronal subgroups located within the nucleus basalis of Meynert (nbM). Both transcript and protein data indicate that cholinotrophic neuronal dysfunction is related to an imbalance between TrkA-mediated survival signaling and the NGF precursor (proNGF)/p75NTR-mediated pro-apoptotic signaling, which may be related to alteration in the metabolism of NGF. The current review summarizes the pathobiology of nerve growth factor (NGF) and its cognate receptors during the progression of Alzheimer’s disease (AD). We demonstrate and validate an interrogative quantitative bioinformatic analysis of a key dysregulated neuronal population linking single population transcript changes to an established pathological hallmark associated with cognitive decline for therapeutic development in human DS and AD. The dysregulated transcriptomic profile of trisomic BFCNs provides key information underscoring selective vulnerability within the septohippocampal circuit.Ĭonclusions: We propose both expected and novel therapeutic targets for DS and AD, including specific DEGs within cholinergic, glutamate, GABAergic, and neurotrophin pathways, as well as select targets for repairing oxidative phosphorylation status in neurons. Leveraging Ingenuity Pathway Analysis and KEGG analysis, we linked differentially expressed gene (DEG) changes within MSN BFCNs to several canonical pathways and aberrant physiological functions. Results: Ts65Dn mice had unique MSN BFCNs transcriptomic profiles at ~6 MO clearly differentiating them from 2N mice. We performed high-throughput, single population RNA sequencing (RNA-seq) to interrogate transcriptomic changes within medial septal nucleus (MSN) BFCNs, using laser capture microdissection to individually isolate ~500 choline acetyltransferase-immunopositive neurons in Ts65Dn and normal disomic (2N) mice at 6 months of age (MO). Methods: We utilized Ts65Dn mice to understand mechanisms underlying BFCN degeneration to identify novel targets for therapeutic intervention. The Ts65Dn trisomic mouse model recapitulates both cognitive and morphological deficits of DS and AD, including BFCN degeneration. Current therapeutics have been unsuccessful in slowing disease progression, likely due to complex pathological interactions and dysregulated pathways that are poorly understood. Background: Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer’s disease (AD).

#El yate fajardo

[orphee-aux-enfers]

J'ai publié 971 fois en 2022

C'est 971 billets de plus qu'en 2021 !

75 billets créés (8%)

896 billets reblogués (92%)

Les blogs que j'ai le plus reblogués :

@le-seraphin-aux-cieux

@elytrians

@writing-is-a-martial-art

@troubled-bog-witch

@corrode-in-repose

J'ai étiqueté 709 billets en 2022

Seulement 27% de mes billets ne comportaient pas de tag

#mon seraphin - 71 billets

#mcr - 66 billets

#art - 64 billets

#goncharov - 43 billets

#space - 38 billets

#depeche mode - 30 billets

#unreality - 29 billets

#tagged in - 25 billets

#music - 22 billets

#birds - 15 billets

Longest Tag: 139 characters

#i will not seek serious help from people substantially younger than me (if i seek help it will be small and nostakes designed to help growt

Mes billets vedette en 2022 :

n°5

Voir l'intégralité du billet

15 notes - publié le 26 novembre 2022

n°4

Voir l'intégralité du billet

17 notes - publié le 23 novembre 2022

n°3

Not writing, not not writing, but a secret third option (collecting all possible albums that might be relevant in the timeline of the story into a spotify folder)

18 notes - publié le 29 novembre 2022

n°2

Thank you for tagging me @corrode-in-repose this is fun!!

Rules: You can usually tell a lot about a person by the type of music they listen to. Put your playlist on shuffle and List the first 10 songs, and then tag 10 people. No skipping! 

Il Se Noie - Trisome 21

Wreck - Gentle Giant

You're Gonna Go Far, Kid - The Offspring

Broken Teeth - the Cemetary Girlz

The Louvre - Sparks

Pain - Three Days Grace

Violence Grows - The Fatal Microbes

Devil's Answer - Atomic Rooster

Spent the Day in Bed - Morrissey

Break Right In - Buzzard Buzzard Buzzard

Well, that is, in fact, as much of a mess as the folder I put on Shuffle is! The only one that I haven't listened to more than once in the last two months is Spent the Day in Bed, and I'm mildly embarrassed by this.

tagging, with zero obligation attached, I just know you all like music: @le-seraphin-aux-cieux @thesunhungfomastring @prongsisthesun @euphorial-docx

20 notes - publié le 7 décembre 2022

Mon billet n°1 en 2022

56 notes - publié le 26 novembre 2022

Obtenez votre année 2022 en revue sur Tumblr →

#tumblr2022 #année en revue #mon année tumblr 2022 en revue #votre année tumblr en revue #year in review #my 2022 tumblr year in review #your tumblr year in review #I am proud of the dave gahan post tbh #long post

[beyond-mogai-pride-flags]

XYYY Pride Flag

48,XYYY syndrome: a rare Y trisomic (chromosome number) condition characterized by mild-moderate developmental delay (especially speech), normal to mild intellectual disability, large, irregular teeth with poor enamel, tall stature and acne. Radioulnar stenosis and clinodactyly have also been associated. Children generally present typical genitalia, while hypogonadism and infertility is frequently reported in adults.

-ap

#disomy #quadrisomy #tetrasomy #trisomy #trisome #poly-y #polysome #polysomy #disabled #disability #rare disease #48 XYYY syndrome #chromosomes #chromosomy #multisomy #intersex #pride flag #mogai #lgbti #lgbtqi #lgbtiq #tetrasomal #anomaly #karyotype #trisomal #infertile #Hypogonadism