#hct

[ascene]

6.14.07

#joe trohman #patrick stump #pete wentz #2007 #hct

[prettyoddfever]

#hct

[whyfalloutwhenyoucanpanic]

#ryan ross #alex greenwald #panic at the disco #phantom planet #hct #2008

[eusuntgratie]

The quote is from this interview!

https://www.tvguide.com/news/red-white-royal-blue-director-viral-rehearsal-photo-of-alex-and-henry/

thank you so much! i am extremely feral about this photo and i love knowing more about the bts; i hadn't read this one! thank you to @bribumblebee for sending this to me too <3

#needed this for very important research purposes 😏 #rwrb bts #hct

[modigod]

i did this gif a literal month ago

also LOOK I FINALLY DID NICK'S OOAK OMGGGG

all of my ocs are based on lps/mlp toys i used to play with when i was 8 yrs old btw

#oc artwork #digital art #art #fanart #artwork #artist #original character #oc art #original character art #HCT CANON #HEROES CRY TOO #HCT #hct is my future book abt my ocs yeah cringe #yeah #i love nick #Nick Crow

[masarca]

MASAR Chartered Accountants Participation at Dubai Women's College - HCT Careers Expo

MASAR Chartered Accountants, a leading player in the financial services sector, was honored to participate in the respected Dubai Women’s College – (HCT) Careers Expo. The event took place on Wednesday, February 21st, 2024.

As part of our commitment to promoting talent and contributing to the growth of the financial sector, MASAR’s team conducted interviews during the Careers Expo. The focus was on providing internship opportunities, allowing students to gain hands-on experience in various financial services offered by MASAR.

In addition to internships, MASAR is actively seeking highly educated UAE youth for immediate hiring in diverse financial departments, including Corporate Tax and Audit, of which reflect our dedication to empowering the next generation of financial professionals.

MASAR’s team consisted of our Business Development Manager, Ms. Bushra Al-Awadi, along with Mr. Motasem Alsayed Sulaiman, HR Manager. They’ve interviewed bright graduates and intern students on the spot. Moreover, they have explained the future of the financial sector and the significant role MASAR plays in empowering UAE youth.

“We are excited to engage with the talented students at Dubai Women’s College – HCT and provide them with valuable opportunities to encourage their careers in the dynamic world of finance. Our commitment extends beyond internships, as we actively seek to hire individuals who share our passion for excellence,” said Ms. Bushra Al-Awadi, Business Development Manager at MASAR.

The presence of Ms. Bushra Al-Awadi and Mr. Motasem Alsayed Sulaiman at the event reflected MASAR’s dedication to bridging the gap between academia and industry, showcasing the vast potential within the financial sector.

ABOUT MASAR CHARTERED ACCOUNTANTS:

MASAR Chartered Accountants is a leading name in the financial services sector, specializing in Corporate Tax, Audit, and various financial solutions. Committed to excellence and innovation, MASAR aims to be at the forefront of shaping the financial landscape in the United Arab Emirates.

#corporate tax in uae #uae corporate tax #tax agency in uae #corporate tax in dubai #tax advisor #auditing companies in dubai #audit firms in dubai #accounting services #HCT #careers #career advice

[informasidigitalfarmasirorotan]

Yuuk kita cari tau obat Hidroklortiazid (HCT)

mari kita simak informasi biografis dibawah ini

#hct #hidroklortiazid #antihipertensi #obatdarahtinggi #pkmrorotan #pkmcilincing

[presslakay]

Mission multinationale | Une délégation onusienne en visite en Haïti pour évaluer l’évolution de la situation

Une importante rencontre de travail a eu lieu, ce jeudi 12 octobre 2023, entre le Premier Ministre Ariel Henry, d’autres membres du gouvernement et une délégation onusienne ayant à sa tête M. Jenca Miroslav, sous-secrétaire général des Nations-Unies chargé de l’Europe, de l’Asie centrale et des Amériques au Département des affaires politiques et de la consolidation de la paix. Les discussions ont…

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#Ariel Henry #HCT #Insécurité #Mission multinationale de soutien à la sécurité #Nations-Unies

[wack-ashimself]

Now this could be a scientific principle that's already been established but I'm going to tell you my perspective. I call it the human chaos theory. Hct. It's a principle that anybody anywhere at any time could do anything. Good or bad alike. Your hero could all of a sudden strip naked and punch a baby. Your enemy could all of a sudden go risk their life to save your aunt. Anybody is capable of anything and at any possible probable time if given the right circumstances and or resources. What does this mean? Inspiration. Hope. Also damnation. Because the best moment of your life and the worst are both possible with human beings around. And being yourself a human being, you contribute to that principle...

#hct #human chaos theory

[ijcimr]

 Acute pancreatitis in Thalassemia post allogeneic stem cell transplant with Cyclosporine-A as a possible etiology: A report of two cases by Narendra Agrawal in International Journal of Clinical Images and Medical Reviews

Abstract

Cyclosporine is an important component of GVHD Prophylaxis in Hematopoietic Stem Cell Transplant (HCT). It has narrow therapeutic index and is known to cause hypertension, electrolyte imbalances, Acute Kidney Injury, etc. High suspicion of these adverse effects helps us in managing them effectively. We report here two cases of pediatric age group who presented with acute pancreatitis post matched sibling HCT for Thalassemia transplant. To our knowledge we could find only 2 case reports of Cyclosporine induced pancreatitis post HCT in literature and none reported post HCT in Thalassemia. Diagnosis of acute pancreatitis especially in pediatric age group can be challenging without high suspicion.The purpose of our report is to highlight the importance of keeping acute pancreatitis in differential of unwell child post HCT in Thalassemia and careful rechallenge of Cyclosporine may be possible with careful monitoring, thereby not compromising on GVHD prophylaxis.

Key-words: Pancreatitis, Cyclosporine, Thalassemia, GVHD prophylaxis

Key Messages: This report highlights the importance of suspecting pancreatitis in a paediatric thalassemia patient post allogeneic stem cell transplant with cyclosporine –A  as possible causative factor. CSA reintroduction can be attempted with careful monitoring after recovery.

Introduction

Cyclosporine (CsA) is a cyclic polypeptide immunosuppressant agent. It is produced as a metabolite by the fungus species Beauveria nivea1. CsA has been used extensively for immune suppression in allogeneic hematopoietic cell transplantation (alloHCT) as well as solid organ transplants for prevention and treatment of graft versus host disease (GVHD) and graft rejection1. CsA has a narrow therapeutic index and requires therapeutic dose monitoring. Common adverse effects of CsA include nephrotoxicity, HCT, hypertension, and hypomagnesemia1. Acute Pancreatitis has been reported with the use of CsA in organ transplants2.

With an extensive literature search, we could not find any report of CsA induced acute pancreatitis after  alloHCT for thalassemia or other hemoglobinopathies. Here we report two pediatric patients with thalassemia major, of CsA induced acute pancreatitis after HLA matched family donor HCT.

Case History

Case 1, a 2-year-old female child with Thalassemia major, presented on day +66 of HLA matched mother donor alloHCT with a history of constipation, irritable behavior, episodes of crying, decreased oral intake and vomiting of 2 days duration. Abdominal examination was remarkable for mild diffuse tenderness and sluggish bowel sounds. X-ray abdomen was suggestive of dilated colon while an USG of abdomen was suggestive of gaseous bowel distension. Pediatric Surgery review suggested a possibility of subacute intestinal obstruction. The patient was treated conservatively by withholding oral foods and fluids (NPO) and application of bisacodyl suppositories. Constipation resolved but she continued to remain irritable with the persistence of abdominal signs. A possibility of acute pancreatitis was considered and serum amylase and lipase were sent which turned out to be 183 IU/L (normal range 22-80) and 2350 IU/L (normal range 23-300). CT Abdomen was notable for modified CT severity index for acute pancreatitis (CTSI) of 43.  A careful review of her drugs and history of illness was carried out. She was not found to be suffering from viral prodrome anytime in the previous month. Her serum calcium and triglyceride levels were normal while PCRs for CMV and EBV were negative. She was receiving CsA along with prophylactic acyclovir, penicillin V and co-trimoxazole. Her plasma CsA trough level was 61 ng/mL on the day of her presentation. A possibility of CsA induced acute pancreatitis was considered4. Naranjo algorithm for causation score was 7 for CsA suggesting probable causation5. Her blood pressure and renal functions were normal. She had no other CsA toxicity. With conservative management her symptoms improved over 1 week, USG done after 1 week was suggestive of resolving pancreatitis with falling levels of serum lipase and amylase. She was shifted to Mycophenolate Mofetil (MMF) for GVHD prophylaxis. On day+100 follow up, her chimerism was maintained at 100% donor, but liver enzymes were raised. After excluding infective and drug-induced hepatitis, a possibility of liver GVHD was considered. A decision to re-challenge with CsA under close monitoring was taken. CsA was re-introduced starting at low doses with monitoring of amylase and lipase levels and close monitoring for clinical signs. She did not have a repeat episode of acute pancreatitis and is currently on tapering immunosuppression on day+260 of follow up.

C ase 2, a 4-year-old female child with thalassemia major presented on day+154 of HLA matched sibling donor alloHCT with a history of abdominal pain, vomiting and poor oral intake of 2 days duration. The patient had no history of fever. On examination, the patient had tachyuration. The patient had no history of fever. On examination, the patient had cardia, normal blood pressure for age, abdominal distention with mild diffuse tenderness. Her USG was suggestive of the bulky pancreas, amylase, and lipase levels were 643 IU/L and 4253 IU/L. The plasma CsA trough level was 252ng/mL. Her chimerism test showed 68% of donor cells. A careful review of her clinical history, lab results, and medications couldn’t find other causes of acute pancreatitis than CsA. Naranjo algorithm causation score was 7 for CsA suggesting probable causation5. There were no other CsA toxicities. CsA was stopped and she improved with conservative management. The patient was started on MMF for GVHD prophylaxis thereafter. She was considered for a re-challenge of CsA especially after our experience of successful re-challenge of CSA in our previous patient. She was restarted on CsA starting from low doses with amylase and lipase monitoring from day +185 onwards. Currently, she is on escalating doses of CsA on day +225 of follow up with donor chimerism improved to 76%.

Discussion

Ito, T. et al showed that intravenous injection of CsA 10 and 20mg/kg body weight (BW) in rats increased the content of pancreatic amylase and protein and decreased the content of pancreatic DNA6. Histologically, intraacinar vacuolization and individual cell necrosis were observed6. CsA induced a significant increase in serum amylase and pancreatic wet weight in a dose-dependent manner6. Qi C et al reported acute pancreatitis in a 16-year-old female patient with acute leukemia on day 24 of alloHCT with CsA or Tigecycline as potential causative agents4. In a case report by Guo R et al from China, CsA induced acute pancreatitis was reported on day+20 of HLA matched alloHCT in a 49-year-old male with AML-M27.

Whether Acute pancreatitis developing in post alloHCT patients with relatively lesser duration of exposure to CsA is idiosyncratic or dose-dependent is yet to be elucidated. Although animal experiment data points towards dose-dependent toxicity, in both our cases acute pancreatitis, developed at acceptable plasma levels, questioning this notion.

Other than that, Post-transplant diabetes mellitus (PTDM) is a complication that takes place after solid organ transplant as well as alloHCTs, with reported incidences ranging from 2 to 53%. Cyclosporine is one of the risk factors for developing PTDM probably due to direct toxic effects on beta cells of the pancreas8.

From this experience, we conclude that studies are needed in the pathogenesis of CsA induced acute pancreatitis in post alloHCT patients. High suspicion of acute pancreatitis should be kept in post alloHCT patients with abdominal signs and symptoms especially in pediatric patients who may not be able to communicate the typical pain history. CsA re-challenge didn’t precipitate pancreatitis in our patients.

Declarations

Funding: Funding information is not applicable to this study.

Conflict of Interest: All authors declare no conflict of interest to declare.

Compliance with Ethical Standards

Ethical Approval Statement: All authors stated that the study has been approved by the appropriate institutional review board and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Acknowledgements We would like to acknowledge Dr Rayaz Ahmed, Dr Vishvdeep Khushoo and Dr Pallavi Mehta in treatment of the patients. We thank all the members, and staff of Rajiv Gandhi Cancer Institute and Research Centre, India for their contribution in the conduct of the study

For more details: https://ijcimr.org/editorial-board/

#Pancreatitis #Cyclosporine #Thalassemia #GVHD prophylaxis #HCT #nephrotoxicity #hypertension #NPO #PTDM #Narendra Agrawal #ijcimr

[oncozine]

Mismatched Unrelated Donors: A Key to Erasing the Gap in Donor Availability in HCT

#background #bone-marrow #ethnic #hct

[ascene]

5.30.07

#patrick stump #pete wentz #joe trohman #andy hurley #fall out boy #2007 #hct

[prettyoddfever]

#ryan #hct

[ict-misr]

اقبال كبير بالبريد على شراء كراسات شروط "سكن كل المصريين ٣"

اقبال كبير بالبريد على شراء كراسات شروط “سكن كل المصريين ٣”

(more…)

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#&quot;سكن كل المصريين ٣&quot; #hct #misr #آآ سى تى #البريد #خالد أبو المجد #عبده #علوان #مصر

[nightseeye]

Teehee, OC stuffs mainly, but lotsa Fresh in there too. Even did a lil writing based off the middle comic (fresh and HCT (square robo), put it in a readmore

Its set after game events, and also my undrawn comic events regarding my two ocs, just a lil convo between an protective guard robo and the guy who caused them to almost kill their boss

Lel had swept out like a whirlwind, leaving the two in silence, studiously ignoring one another as they waited for the scientist to return. Fresh fidled with their headset, while the robot simply stared straight at the empty doorway Lel had disappeared through.

"STATEMENT: Clear dislike of subject." Cut through the silence, leaving the beat surprised it was broken at all.

Fresh couldn't help but roll their eye once they actually registered the obvious understatement. Anytime they came to talk to Lel, the robot was never too far away, hovering in a corner somewhere like the obnoxiously overprotective guard dog it was built to be. Not the worst reaction they've gotten from someone, but after enough time it became... grating.

"Unsurprising." The beat couldn't help the disdain and dismissal that dripped off the single word, cutting their gaze away from the robot.

"EXPOUND: Subject is the cause of PRIMARY OBJECTIVE failure."

That alone brought their attention back to the conversation. It wasn't rare that Fresh learned whatever particular reason a person had for hating them, but they haven't yet heard one from the robot. Usually it was something along the lines of tearing apart the Treeangle, or turning the seas pink. Nothing ever personal enough that they actually cared - beyond those flowers they beat up during their freedom-induced rampage, - but the beat was curious to hear whatever reason had taken it so long to spit out.

"Yeah? And what's that?"

The robot gazed up ever so slightly, as if reading it out from thin air: "PRIMARY OBJECTIVE: Keep USER Lel safe, hale, and happy."

Fresh couldn't help but flinch back as the robot slowly turned to face them, a single glowing pupil growing to encompass its entire eye in an admittedly very unnerving display. They could almost imagine how threatening the machine had looked when corrupted with the single spark of pink flickering in its eye, sharp claws pointing at the beat.

"STATEMENT: Cause of PRIMARY OBJECTIVE failure."

That simple sentence was just the truth, but nothing had ever felt more like an accusation, judgement, and condemnation than that. It struck true like an execution, guilt tying a noose around their neck and rendering them silent. There was nothing Fresh could say to to defend themself, no excuses to give, and none that they'd want to try. Maybe if they hadn't grown so close to the scientist these past few weeks, that single sentence wouldn't feel so bad, but... the knowledge that they had a hand in Lel's pain, in that kind scientist's fear...

Maybe they could understand HCT's hatred a little better.

"VEXATION: Subject is.-"  The fragmented sentence was was enough to pull their thoughts out of the spiral they were going down, and Fresh couldn't almost help but feel grateful towards the robot, even as it turned back away from them. With its pupil returned to normal size, they were able to see its expression change from angry, to fustrated, and settle on annoyed as it found a way to complete its sentence, "..tolerated, by USER Lel."

Fresh snorted.

"I think they do more than tolerate me." They replied, mind drifting back to all the times they've poked around the lab, only to be caught by Lel, and not scolded, but taught about how whatever equipment they were poking at worked.

How, even as the scientist threw a million questions their way, they were kind enough to notice the ones the beat shied away from, and not ask anymore. The snacks, the smiles, the simple greetings and waves if they ever passed one another elsewhere in Paradise. They wouldn't be surpised if Lel counted them as an friend.

The beat knew they counted them as one.

There was a sound Fresh could almost describe as a prim sniff, if it hadn't come from the robot bigger than they were, "EXPOUND: Lethal force distinctly unauthorized."

Lel rushed back into the room to see Fresh in tears on the floor, gasping for air as they cackled, while HCT stood, seemingly unmoved as it glared off to the side.

#i also need it to be understood that none of this is romantic lel's first and only romantically coded love is science #fresh and lel is more of a #just shapes and beats #jsab #jsab oc #jsab blixer #jsab fresh #jsab art #lel and hct #nighty arts #sketch #nighty writes #th writing turned out slightly different in tone compared to the lil comic thing but thats mostly bc i was kinda doin whatever in the comic #while the writing had a lil more thought/backstory behind it than ''guard threatens guy for causing Issueswow ur so niceys to me are we frie #while HCT and lel are like. "you brought me to life respect me and are kind and smart. ur so fucking bad at self care tho its AWFUL''

[seokgyuu]

Here Comes The Sun • Part 29

previous • masterlist • next

synopsis: what’s supposed to be just another year of fun and games at one of South Korea’s top universities turns into a rollercoaster of emotions for you. stuck between best friends and former crushes, you try to find love, friends and most importantly yourself.

tag list: @xfirebenderx @binniebutter @just-some-random-blogger @iwanttohitmyself @lavenonie @8chu @1122ljh @kkakkameori @dreamerhaos @tara-drabbles if you want to be added to the taglist fill out the form or drop me an ask! <3

a/n: so… what a night of reveals right 🤭. now who’s gonna be endgame? any ideas? 🤩

#fanfic #svt au #dino x reader #mingyu x reader #jihoon x reader #seventeen #fanfiction #seokmin x reader #hcts au #smau #svt imagine #svt fic #dokyeom x reader #social media au