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silverstars87 · 5 months

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So I finished all 16 rounds of chemo and now I’m first case on Monday 12/4 for bilateral nipple sparking mastectomies, right port removal, and bilateral expander placement with a cellular dermis.

I Wish this wasn’t happening.

I cry a lot. And my husband won’t even speak to me for the past 5 months.

#nursing #nurblr #nurse practitioner #registered nurse #aprn #triple negative breast cancer #breast cancer #brca1

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thesaltyoncologist · 4 months

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Today I sent a 21 year old home with hospice. Merry fucking Christmas.

#medblr #sometimes oncology sucks #the best medicine is sometimes no medicine #BRCA1 is fucking awful #BRCA1 #oncology #breast cancer

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rileywrites-parker · 7 months

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For anyone who has been with me for the long haul and maybe, potentially remembers some of the gynecological issues I have gone through - endometriosis and adenomyosis officially rendered me infertile and in constant pain. My uterus was a war zone, completely unable to support life.

I had genetic testing done and found that I am positive for a BRCA 1 genetic mutation.

I had a partial hysterectomy about a month ago. I was able to keep both of my ovaries despite a large endometrioma on one, for the time being, with the intent being to heavily monitor changes going forward.

I am struggling mentally, to be honest. I am so lucky to have had my daughter when I did. Three different doctors told me that I never would. Many women dealing with the same diseases aren't so fortunate. It feels greedy to mourn over the lost potential of another miracle baby, but I am, no less. I wanted to be able to give her all of me, without pain or the cancer timebomb that was; I will keep telling myself this was the best choice given the data.

I don't expect a response and this post is not meant to come across as self-pitying. More or less just wanted to type it out for the universe. I'm going to be fine.

For any of you that are dealing with the same or similar - I am sorry and i understand. I see you. I hear you. Please never feel guilt or regret.

#shouting into the void #endometriosis #adenomyosis #brca1

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pandaspwnz · 4 months

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WHY is it always so cold near the feet in MRI machines!! I wore leggings, 2 pairs of socks AND I had a blanket on and I STILL ended up with popsicle sticks for feet!

#every dang time!!#this is my third time getting an MR scan and it’s been so cold every time i hate it!!#mri #brca1 #brca1 defect #my post #hospital #is it something about keeping massive complicated machinery cool? yes probably #but it's a personal inconvenience to me specifically

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bpod-bpod · 1 year

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Obesity-Cancer Link

A person carrying a mutation in either of the tumour suppressor proteins BRCA1 or BRCA2 is at increased risk of developing breast cancer. So too are people with obesity and diabetes. But whether obesity could exacerbate the risk in people with BRCA mutations was unknown. Recent research suggests that indeed metabolic and genetic risk can be cumulative. The image shows nuclei (blue) of milk duct cells from a person with a BRCA mutation with evidence of DNA damage shown in red. A study of such cells revealed the extent of DNA damage in BRCA mutation carriers positively correlated with body mass index. And blocking obesity related hormone signals in these cells could lessen such damage. The new findings suggest that while maintaining a low body weight is no guarantee of preventing breast cancer, addressing lifestyle, diet and metabolic health may be especially important for people already at increased genetic risk.

Written by Ruth Williams

Image from work by Priya Bhardwaj and colleagues

Department of Medicine, Weill Cornell Medicine, New York, NY, USA

Image copyright held by the original authors

Research published in Science Translational Medicine, February 2023

You can also follow BPoD on Instagram, Twitter and Facebook

#science #biomedicine #cancer #oncology #brca1 #brca2 #genetic risk #breast cancer #jolie gene #immunofluorescence #cytogenetics #obesity #bmi

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datenarche · 2 months

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#Biontech #BRCA1 #Corminaty #COVID-19 #COVID-19Impfstoff #DNA-Kontamination #InternationalCrisisSummit #KevinMcKernan #Krebs-Schutzgene #Moderna #modRNA #modRNA-Gentherapie #mRNA #mRNA-Gentherapie #p53 #Pfizer #Plasmide #Plasmidfragmente #SV40Promotor

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oneindiglaura · 8 months

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De wandeling van vanochtend was erg mistig maar mooi. Een paar cadeautjes van de natuur.

#nederlandse blog #autisme #hersenschudding #nederland #nederlands #adhd #poezie #writing #fibromyalgia #fibromyalgie #brca1

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romased · 1 year

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guess the # of therapy sessions needed to embrace this body

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pathologylab · 1 year

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The breast cancer panel at Genes2Me uses benchtop Next Generation Sequencing (NGS) based analysis to screen pathogenic mutation in BRCA 1 & BRCA 2 for breast and ovarian cancer. BOOK NOW!! https://t2m.io/brcas For more details, Call us at 18001214030 or drop us an email at [email protected] to know more about the product.

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silverstars87 · 8 months

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I finished phase one of chemo! Carboplatin & Taxol are done! Smell ya later!

I now have my mastectomy & expander date for December and tentative implant placement & Fallopian tube removal for April.

This is getting real. And I feel better now that I’m partway through.

#nursing #nurblr #nurse practitioner #aprn #registered nurse #breast cancer #triple negative breast cancer #BRCA1

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walrusmagazine · 1 year

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Surgery Minimized My Chances of Getting Cancer. It Also Altered My Self-Image

Because of a hereditary gene mutation, I removed my breast tissue, ovaries, and fallopian tubes. I had to unlearn a lot of feelings about how I look

Underneath all of those uncomfortable feelings is a simple need: to see something familiar when I look in the mirror. What I want is to recognize myself again, to see not an upright version of a butcher school diagram but a fierce size twelve in cute shoes who has veritably cheated death. Every time I start to measure the distance from here to there, I fall into that old trap that healing is linear. Reintegrating those parts of ourselves we would prefer not to look at is not a process with an ending.

Read more at thewalrus.ca.

#Health #Cancer #Mastectomy #BRCA1 #body image #Self esteem #Illustration #Carey Toane

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utopiamedspa · 2 years

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Christie’s surgical journey will shock you. Upon finding multiple, painful lumps in both breasts in 1999 Christie did everything she was supposed to; she made an appointment with a doctor for evaluation but was told that the lumps were benign and to return for surgery ‘when they actually became real cancer’. ”Insurance was not going to cover the cost of a very expensive surgery. I tried everything in the hope they would go away on their own. I changed my diet. I prayed with my husband. We finally decided that I should see a plastic surgeon and I wanted the best and back in 1999 that was Franklin A. Rose, M.D.” said Christie. After learning she carries the BCRA genetic mutation, Christie opted to have her ovaries removed at MD Anderson. We want to acknowledge during Breast Cancer Awareness month the life-saving impact of her double mastectomy by Dr. Rose and her surgical team. Christie will have what she hopes to be her final surgery, for a while anyway, tomorrow and the Fox News camera team will be there to see if her 23-year-old implants ruptured when she heard a “popping noise” recently. GENETIC TESTING SAVES LIVES! Tune in to @Fox26Houston morning news with Emmy-award-winning journalist @MelissaWilsonfox26 News on Monday, October 17th & learn more about Christie’s incredible journey on our blog -LINK IN BIO- #fox26forlife #hollyroseribbon #thinkpink #genetictestingsaveslives #previvor #geneticpredisposition #brca1 #brca2 #preventivemastectomy #breastcancerawarenessmonth (at Utopia Plastic Surgery and Med Spa) https://www.instagram.com/p/CjZJPllJShM/?igshid=NGJjMDIxMWI=

#fox26forlife #hollyroseribbon #thinkpink #genetictestingsaveslives #previvor #geneticpredisposition #brca1 #brca2 #preventivemastectomy #breastcancerawarenessmonth

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kareningalls · 2 years

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EVEN THE FAMOUS ARE NOT IMMUNE

A person’s fame or fortune does not protect them from getting a serious illness…even cancer. They are humans just like us. Some celebrities who were diagnosed with one of the gynecologic cancers: Fran Drescher…uterine cancer Kathy Bate…breast and ovarian cancers Judith Blume…cervical cancer Pam Grier…cervical cancer Camille Grammer…endometrial cancer Shannon Miller…ovarian cancer Most…

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#BRCA1 #Chris Everett #ovarian cancer

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harmeet-saggi · 5 months

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Ovarian Cancer - Cause Symptoms Diagnosis & Treatment

Ovarian cancer is a type of cancer that begins in the ovaries. The ovaries are two small, almond-shaped organs located on each side of the uterus. They are responsible for producing the eggs necessary for reproduction and for secreting the female hormones estrogen and progesterone. Ovarian cancer is the fifth most common type of cancer in women and is most often diagnosed in women over the age of 60.

#ovarian cancer #breast cancer #Obesity #Never giving birth #Use of fertility drugs #overweight #BRCA1/2 mutations

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seagull-astrology · 10 months

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C121 BRCA-2 mutation and Kaleigh McEnany

Kaleigh McEnany is the former Trump White House spokeswoman. That is a perfect job for someone that is a Bucket with Pluto handle, her planetary pattern. Kaleight was diagnosed positive with the BRCA-2 mutation when she was twenty-one but she waited to have the preemptive double mastectomy after she was married and have her daughter, Blake Avery. I guess with a Cancer Rising she wanted to enjoy…

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#April Births #Brca 2 Mutation #Brca1 Or Brca2 Gene #Bucket With A Pluto Handle Pattern #Cancer rising #Kaleigh Mcenany #Rectified Chart #Trump Cabinet

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onealgraversen00 · 10 months

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Nf-κb Signaling In Tumor Pathways Focusing On Breast And Ovarian Cancer

ORR and a fifty seven per cent PSA response had been introduced. In sufferers without BRCA mutations, the tumour response price was solely eleven per cent and PSA response 6 per Many of those small molecules are able to restoring the expression of p16INK4a in various cancers. Genistein, an isoflavone current in soybean, is a cancer chemopreventive agent that inhibits cell proliferation and induces apoptosis (Gullett et al., 2010 ). Li et al. reported that genistein represses early breast tumorigenesis by way of epigenetic regulation of CDKN2A by impacting histone modifications as properly as by recruiting the BMI1-c-MYC complicated to the regulatory area in the CDKN2A promoter ( Li et al., 2013b ). In prostate cancer, treatment with genistein increased acetylated histones 3 and four of the CDKN2A transcription start sites ( Majid et al., 2008 ). Thus, soybean merchandise containing genistein could be helpful in preventing breast and prostate cancer by way of transcriptional activation of CDKN2A by modulating its epigenetic silencing ( Li et al., 2013b and Majid et al., 2008 ). Rajendran et al. reported that Nrf2 wildtype mice confirmed a better incidence of colon tumors than Nrf2 heterozygous (Nrf2+/− ) mice when handled with 1,2-dimethylhydrazine. Pancreatic screening in high-risk patients such as BRCA2 mutation carriers has been proposed to reduce PDAC-related mortality. In 2012, the International Cancer of the Pancreas Screening (CAPS) Consortium revealed pointers on the management of patients with elevated risk for familial PDAC (Canto et al. 2013). Just as a result of the genomic check doesn’t pick up a prostate cancer mutation does not mean you don’t have mutation/s that causes prostate cancer. advanced tubo-ovarian cancer. The current commonplace of care in the first-line setting for most sufferers with newly recognized superior tubo-ovarian cancer is platinum-taxane chemotherapy and cytoreductive surgery with a goal to remove all of the seen cancer. significant dose discount and delays. In HRD-positive metastatic pancreatic cancer, veliparib with FOLFOX (folinic acid, fluorouracil, and oxaliplatin) chemotherapy confirmed an ORR of fifty per cent, median PFS of seven.2 months, and median OS of eleven.1 months. In breast cancer, the section three BrighTNess trial randomly We have been actually anticipating one thing as his dad died of prostate cancer and his mom died of breast cancer....but nothing hereditary found. He then took the Guardant blood take a look at and a variety of other variants/mutations have been found, which expanded his therapy options. Reactivation of silenced CDKN2A or the inhibition of epigenetic repression of the gene could be a rational strategy for the prevention or remedy of varied cancers. In comparability with previous trials such because the practice-changing SOLO-1, which was carried out in a My cancer has PTEN misplaced which facilitates the copy of the cancer cells. FOXA1, Si-ZBP-89, Jmjd3, Mutant UHRF1 and c-JUN induce p16INK4a protein expression by re-activation of the CDKN2A promoter. Schematic structure of the INK4a /ARF locus and the function of p16INK4a in cells. of olaparib with bevacizumab as first-line upkeep remedy for advanced tubo-ovarian cancer, no matter BRCA1/2 mutation status. The Monte Carlo simulation of 1,000 patients confirmed that the cost and effectiveness within the PFS illness section have been $3,124 ± $1,534 and zero.905 ± 0.449 QALY for placebo and $139,563 ± $33,046 and 1.544 ± 0.408 QALY for maintenance olaparib. The cost-effectiveness acceptability curve confirmed a nearly 54% likelihood of maintenance olaparib and 46% probability of placebo being a cheap strategy at the threshold of $200,000 per further QALY gained (Figure 4). Furthermore, olaparib didn't significantly improve outcomes in cohort B that comprised different HRD mutations. The trials; PRIMA, PAOLA-1, and VELIA, offered at a Presidential Symposium on the Congress, provide evidence of improved survival for almost all affected person brca1 pancreatic cancer risk sub-types in high-grade superior tubo-ovarian cancer. The enhanced Warburg impact in addition to the elevated production of lactate in ATM-deficient CRPC cells prompted us to determine which enzyme within the glycolysis pathway is regulated by ATM deficiency. Actually, we examined the mRNA stage of LDHA in addition to different enzymes along the glycolysis pathway by RT-qPCR in the two cell strains. Only LDHA was dramatically upregulated in C4-2/ATM-KO cells (Fig. 4B), and this upregulation is further supported by the western blot displaying ~three-fold increase of LDHA protein expression in ATM-KO cells (Fig. 4C). To additional confirm the upregulation of LDHA by ATM loss, we handled C4-2 cells with ATM inhibitor KU and located that the expression of LDHA increased after 72-h therapy of cells with KU (Supplementary Fig. 2).

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