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yogurtberrywrites · 2 years

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“Schlatt Attack”

Warnings: Drug use, Smoking, Violence, Swearing, Death, Ghosts, and Angst (Recommended to readers over 14).

Summary: What if Schlatt survived his heart attack?

Notes: None of this is canon, this is my take on the DSMP. Let me know if there are any other warnings I should put, or if I should change the recommended reading age.

“What the fuck happened?” Schlatt groaned, sitting up in a hospital bed rubbing his head. Ponk was beside him monitoring his health. “You had a….cardio-cerebral infarction. In other words you had a heart attack.” Ponk explained hesitantly. “Wait was it from-” Schlatt was cut off by Ponk. “The alcohol.” Ponk said, setting one of the bottles he had been holding before he passed out on his bedside. “Yeah….” Schlatt said, ashamed looking down at his sheets. “Schlatt, what were you thinking?” Ponk fully aware that Schlatt should be dead. “It just all hurts.” Schlatt mumbled putting his hands to his face. “Schlatt, I understand that you suffer from myotonic muscular dystrophy and Chronic obstructive pulmonary disease.” “Yes yes that’s right.” Schlatt confirmed. “Have you tried to take any medication for it?” Ponk asked.

“Do drugs count?” Schlatt replied with hesitation. “Schlatt!?” Ponk questioned, knowing he was probably drinking more than he could handle. “Look, you know I’m an alcoholic! Everyone knows that! And where am I supposed to get fucking medicine!” Schlatt said aggressively. “Schlatt! You can’t use Drugs and Tobacco and expect them to fix you!” Ponk shouted trying to get it through his thick skull. “THEY DID FIX ME!” Schlatt screamed, grabbing Ponk by the shirt as his breath became unsteady. Schlatt let go of Ponk only to cough uncontrollably into his arm.

Ponk was a bit frightened, but it was his job to help all his patients, no matter how difficult they were. “Here.” He said as he tried to hand a bottle of water to Schlatt. “Get that the fuck away from me. I don’t need that.” Schlatt said, reaching for the bottle of alcohol. “Ah ah ah.” Ponk wagged his finger at Schlatt blocking his hand from the glass bottle. “Asshole.” Schlatt muttered. “Schlatt, I’m not letting you leave till you agree on taking medication and withdrawing drugs.” Ponk threatened. “Oh come the fuck on! You can’t be serious?” Schlatt said, astonished. “Okay, well I bet you can’t last a week without it.” Ponk teased. “Are you challenging me?” Ponk only looked down on him smiling. “If you're gonna bet there's gotta be something in it for me.” Schlatt said pissed off that Ponk was in control now. “I’ll give you a thousand dollars if we can improve your health by the end of the year.” Ponk said. “Ten thousand.” Schlatt stated. “Let’s make it five thousand, or I shave that off.” He said pointing at Schlatt’s facial hair. “Deal!” Schlatt said, pleased as he shook Ponk’s hand. (Also his facial hair is at risk lmao).

“Take it easy, okay. I’ll hook you up with an inhaler for your COPD. Come visit me next week.” Ponk said as he hulled Schlatt to his feet. “Thanks.” Schlatt said as he grabbed the water bottle from before. He guzled it down and threw it into Ponk’s hands. Which only caused a proud smile to form across Ponk’s face. Schlatt smiled back waltzing out the door. His little ears perked up as he walked out of the building with his new found confidence.

. . .

Schlatt arrived at where L’Manberg once was. He looked off to where his great nation once stood. Now only being occupied by a huge crater. He was stunned. “Who the hell pulled this off?” He whispered, impressed. He wasn’t mad because he knew he’d never really cared about the nation itself, but the power he gained from it. He just wanted to know what all went wrong. He knew he didn’t govern the nation right, but he didn’t think someone would go and fucking blow it up. Off in the distance he saw a small figure. It was Tubbo.

“Tubbo!?” Schlatt called as he ran up to him. Tears were running down Tubbo’s face as he looked off to Schlatt. “S-Schlatt?” Tubbo says, his voice trembling. Schlatt came to a halt in front of him, confused. “You look like you’ve seen a ghost?” Schlatt said still not understanding why Tubbo was surprised. “I-We thought you were dead.” Tubbo responded, backing away from him. “What….” Schlatt trailed off in fear. “When you had your heart attack we thought you’d died. We called Ponk t-to take care of you.” He said, staring down at the ground. “You didn’t think to check my pulse!” Schlatt said, chuckling nervously. “Look, we were in a hurry. Trying to stop a war you helped cause!” Tubbo was still upset that he had killed him. Schlatt, noticing the pain, reached out to touch one of the many explosion scars on his face from the execution. “Don’t touch me.” He cursed, pulling Schlatt’s hand away from him. “I-I’m sorry.” Schlatt apologized. “Why did you do it?” Tubbo asked. “Do what?” Schlatt questioned. “Why did you make me your right-hand man?” “I-I…. Fuck, Tubbo! It’s because you reminded me of myself. When I was….a better man.” Schlatt said, looking off to the L’Manhole. “I didn’t want you to become me, so I thought if I kept you close…. You’d be a better man than I ever was.” Schlatt looked back at Tubbo.

Tubbo didn’t know what to say. Schlatt never seemed to care for anyone, but himself. He never thought out of all the people Schlatt wanted to protect…. it would be him. “Hey, but it turns out Manberg really did take the L right?” Schlatt laughed trying to up the mood. “Yeah, Wilbur had a denanator room under Manberg. H-He couldn’t take it anymore-and he blew it up.” Another tear rolled down Tubbo’s face. He quickly wiped it away. “Umm, how long was I out.” Schlatt asked. “It’s been a long time Schlatt.” “Oh….” Schlatt said. “What do we do now?” He asked Tubbo. “We move on.” Tubbo said, turning from Schlatt and walking away.

. . .

Schlatt wandered the server for a few days not knowing what was the next step for him. Manberg was gone and he accepted that, but that meant his purpose was gone. Everyone hated him anyhow. Whatever he did next he had to make sure it wouldn’t hurt anyone else. If it were, no one would ever forgive him. They probably would kill him and make sure he was dead this time. He felt like no matter what he did he’d just push them further away. Was this his purpose to hurt everyone he ever came into contact with? There were so many If’! His true fear was being alone, but he just denied it.

He couldn’t take it anymore! All he heard in his head was his sins, his wrong doings! He couldn’t even remember who he used to be before L’Manberg. He needed to drown out the pain. He didn’t care what Ponk said! It all hurt too much.

He dug up one of the many drug stashes he’d hidden on the server. He opened the chest to find only a few bottles left. He must have gotten drunk the other day and didn’t remember. He didn’t care, this would be enough. He reached for one of the bottles, before hearing a rustle in the brush behind him.

“Okay! Who the fucks is there!” Schlatt said wearily, being completely defenseless. Out of the brush sat up a very confused Wilbur. He just stared at Schlatt puzzled. “A new friend!” He shouted with glee, hugging Schlatt. “W-Will!?” Schlatt also became very confused and uncomfortable. “Yeah?” He said letting go of Schlatt thinking he’d done something wrong. Schlatt hadn’t realized it, but something was wrong with Wilbur. He was discolored and pale. He wasn’t wearing his usual leather jacket and glasses. And was that a yellow sweater? It was freaking Schlatt out. Wilbur was his enemy, but once his friend. Seeing him like this only brought more and more questions.

“Will, what happened to you before L’Manberg blew up?” Schlatt asked. “I-I can’t remember.” Wilbur said, pushing his hands into his forehead, which made zero difference. “A-And why do you keep calling me Wilbur? I’m Ghostbur.” Now Ghostbur was asking the questions. “Um G-Ghostbur are you de….” Schlatt stopped, afraid that Ghostbur wouldn’t be able to handle it. “What? What is it new friend?” Ghostbur asked, concerned. “Never mind. Um, do you know Phil?” Schlatt changed the subject. “Yeah! I love Phil! Can we go see him?” Ghostbur said with new found excitement. “That’s where we're headed!” Schlatt said, only causing Ghostbur more cheer. “Wait, here.” Ghostbur smiled and handed him some sort of blue stuff. “What's-” Ghostbur cut him off knowing just how to answer his question. “It’s blue! It takes the pain away….” “Thanks.” Schlatt said seeing the blue stuff glow as he breathed heavily. ”I saw those bottles you had. I remember Phil said that they were bad for me. I felt funny whenever I ate them, so I stopped. Is that why you're sad?” Ghostbur said with guilt.

“I-I don’t know. Wait, but did you say you remembered?” Schlatt said realizing Ghostbur could remember Wilbur. “I remember before….before h-he,” Ghostbur stopped hugging Schlatt, before crying into his arms. Schlatt knew he must have remembered what happened to his living self. “I know I know.” Schlatt rubbed him on the back, letting Ghostbur cry into him. He wasn’t very good at comforting people, but this was the best he could do. Ghostbur let go of Schlatt and wiped away his tears. “Sorry.” Ghostbur sniffled. Schlatt could see where the tears had rolled down his cheek now had left burning scars on his face. “Ghostbur, you don’t have to be sorry. But are you okay?” Schlatt said, pointing to the scars. “Yeah. It doesn’t hurt much.” He said, his tone more gentle than energetic. “Come on. We gotta get going if we wanna find Phil.” “Wait! Can I hold your hand?” Ghostbur said nervously. “Yeah.” Schlatt smiled, feeling like he was holding a five year old’s hand.

. . .

Schlatt thought if Tubbo still had been at L’Manberg then Phil must have been. He arrived at the crater. Ghostbur was horrified. He may not have remembered much of L’Manberg, but it was Wilbur’s home. “Did I do that….” “No, you didn’t. The past you may have, but he wasn’t in the right mind, okay.” Schlatt said his hands on Ghostbur’s shoulders. “You-He was a good man.” Schlatt said, staring Ghostbur in the eyes. Ghostbur smiled, then caught something out of the corner of his eye. “Phil!” Ghostbur shouted, running towards him. Schlatt, being unable to run due to some of his complications, tried his best to catch up to Ghostbur.

Phil was up in the denantor room which was more visible now from the explosion. He could see a sword in Phil’s hands as he sat there frozen. Dried up blood laid on the blade of the sword. As Schlatt approached he pulled Ghostbur behind him. He could see Phil was thinner and exhausted. He just stared at a button in the middle of what remained of a wall in front of him. “Looks like you’ve aged.” Schlatt laughed hesitantly. “Go away.” Phil muttered. “Phil what happened here.” Schlatt asked. “Why did Will do it. H-He had everything and he just threw it away.” Phil said, looking down to the diamond sword. Tears rolled down his face falling onto the blade. “I hope he’s happy. He’s happy that this is all gone.” The anger was in Phil’s voice, but he still missed him. Schlatt was speechless. He didn’t know what to say.

But Ghostbur was growing too impatient. He couldn’t wait on Schlatt anymore. He pushed past him wrapping his arms around Phil. Phil was about to point the blade at him before realizing who it was. “Will!?” He said dropping the sword to the ground. Phil stood up and embraced him. “How are you here?” He said, staring at Schlatt. “Um, Ghostbur, could you wait outside for us?” Schlatt really asked as more of an order than a favor. Ghostbur nodded understanding. He looked up at Phil, his eyes sparkling a deep blue. Tears of joy rolled down Phil’s face as he parted Ghostbur’s curly mess of hair out of his face. Schlatt directed him to where he could wait as they talked and he cheerfully made his way over to where L’Manberg used to stand.

“Phil, what’s wrong with him?” Schlatt said with worry. “I think he’s a ghost. He’s different now….he’s happy.” Phil smiled watching Ghostbur roll down a hill over and over again. “He acts…. younger. Why’s that?” Schlatt asked Phil. “I think he was happier as a child, so it’s in his nature to be his younger self.” “Phil, why were you here, not taking care of yourself.” Schlatt confronted. “H-He asked me to-” Phil looked down at the sword. “Phil I-” Schlatt connected the dots. “It’s for the best. It worked out in the end, right?” Phil had more tears falling from his face. “Phil, you did the right thing. It might not have been the best choice for-Wilbur, but he asked you to take the pain away.” Schlatt said feeling the same pain.

Meanwhile, as Phil and Schlatt conversed Ghostbur laid in the grass hanging his legs over the blown up crater. He crest his hand around the white clouds in the sky. He’d imagined what it would feel like to touch one. He mindedly pointed out shapes he saw in them as he thought. He hummed the L’Manberg Anthem as he tried to remember what the huge pit once was. He watched as the sky grew darker and the clouds blocked the light. A little toddler-like whine came from his mouth, upset that the sun had disappeared. He closed his eyes listening to all around him. It felt so….peaceful. Ghostbur would have never been able to enjoy this without Wilbur’s destruction of L’Manberg.

A stinging came to his face as he suddenly opened his eyes. He wiped at his cheek where a raindrop had soaked into his skin. He had not yet experienced rain and didn’t understand that it could hurt him. The sky started erupting with rain. Ghostbur got up in fear, feeling it burn his skin. He tried to run towards Phil and Schlatt, but slipped on the wet grass. Everything burned and in a moment of agony he screamed for Phil.

Back by Schlatt and Phil they were just finishing their talk. Schlatt had noticed the storm that had rolled in, but thought nothing of it. Schlatt wasn’t sure why Ghostbur’s face burned from his tears, but he didn’t think water was the problem. Suddenly they both heard someone scream. “PHIL!” Ghostbur cried out stuck to the ground like a magnet. “Wilbur!” Phil yelled in distress. “Fuck I forgot! Water must hurt him!” Schlatt shouted, ripping off his suit’s jacket. He rushed over to Ghostbur’s aid. Phil stood there frozen in fear. Schlatt used his jacket like an umbrella over his head. “Come on Ghostbur!” Schlatt reached his hand out. “I-I can’t!” Ghostbur sobbed covered in mud.

“Wilbur couldn’t Ghostbur! But you can!” Schlatt shouted, grabbing Ghostbur’s hand. Ghostbur pulled his feet out of the mud one by one. He winced in pain being covered in the wet muck. Schlatt started dragging Ghostbur behind him, forcing Ghostbur to keep up the same pace. Schlatt ran through the pain as his legs cramped up. Ghostbur now had his jacket wrapped around him. Phil reached out his arms to Ghostbur as he melted into Phil’s arms (Not literally). Schlatt fell to the ground exhausted. “I-Is he okay.” Schlatt panted out. “He’s got a lot of burns, but I can patch him up.” Phil smiled amused by Schlatt’s act. Ghostbur didn’t say a word, only whimpering and sobbing into Schlatt’s jacket. Phil hushed him quietly to calm him down. “Schlatt?” Phil asked kindly. “Yeah?” Schlatt sat up. “You need a place to stay right?”

. . .

Schlatt came out of his room with his Yankees hat on and his favorite Obama T-shirt. His eyes drooped with exhaustion. “Hey, Phil.” Schlatt greeted, grabbing his morning coffee. Schlatt had been living with Ghostbur and Phil since their chat. Ghostbur was still a little bandaged up from his burns. He’d also had some neighbors, Techno and Ranboo. He was still mad with Techno, but was charmed by Ranboo. He joined Phil and Ghostbur at the table watching them eat their stupid biscuts. “Did you sleep well?” Phil asked, munching on a jam filled crumpet. “Could've been better.” Schlatt sighed. “Another nightmare?” Phil said concerned. “Yeah.” Schlatt looked down at his plate where his food was getting cold. “I’m gonna go take a smoke.” Schlatt said heading out the door without a single bite of breakfast.

Schlatt sat out in the cold, smoke rings being blown from his mouth. He may not have been allowed to drink, but Ponk didn’t say anything about cigars. He was changing. The change scared him. He couldn’t even remember the last time he’d cursed out someone’s name. He felt like he was getting too soft. And now he had an inhaler that made him look like some kind of asthma kid. He was afraid that if others looked down upon him like this they’d think he was weak. He was mad too. He was stuck in this arctic desert. He couldn’t go back, not after what he did.

Then he heard a sound all too familiar. He barrel rolled to the side as an arrow wished past him, cutting the side of his ear. He screamed in agony grabbing at the bleeding cut on his ear. It had torn through his flesh leaving a missing chunk out. Another arrow then cut through his hat nailing it into the back porch. He then heard a crack of a twig from behind. He spun around to face his attacker. “Quackity!?” Schlatted shouted in surprise. Quackity dropped his crossbow running up to Schlatt only to pull him back into the brush. “Quackity what are you d-” Schlatt yelped before Quackity covered his mouth.

“Schlatt! Schlatt!” Phil shouted, stumbling around the porch trying not to step on any arrows. “You gotta be quiet or they’ll hear you.” Quackity hissed. Schlatt mumbled trying to get Quackity’s hand off of him. “I’m gonna let go okay. And then you're gonna shut up alright.” Quackity said sternly. Schlatt nodded before licking Quackity’s hand. “Ah god dammit! You fucking whore!” Quackity yelled trying to shake Schlatt’s spit from his hand.

Schlatt then ran from his killer. The last time they’d talked he got shot by him. He wasn’t gonna make the same mistake twice. “Schlatt, wait! Come back!” Quackity called chasing after him. They raced through the forest. Schlatt made sure to smack every tree branch into Quackity’s face for good measure. But the wood was really dense and filled with roots. Schlatt had to swerve through the trees and try to lose Quackity. He didn’t know if his legs could handle it any longer. A log was approaching ahead of Schlatt. He was gonna have to jump it. He pushed one of his hands off of the log as he landed on the other side. Unfortunately the more athletic Quackity jumped off of the log and onto Schlatt, pinning him to the ground.

“Let go of me!” Schlatt squirmed underneath Quackity’s hold. “Not until you give me some answers!” Quackity ordered. “Hmm… No.” Schlatt said like a little toddler. “What the fuck do you mean no!?” Quackity laughed. “I mean why should I tell you anything!” Schlatt said in hatred. “Well you could have told me that you weren’t dead! It’s been three months since L’Manberg and your hiding out in the middle of nowhere!” Quackity said, pushing his crossbow in Schlatt’s face. “Easy with that thing!” Schlatt quived. “You left me when I needed you most! You left me with a blown up country!” Quackity roared. “And you killed me!” Schlatt screamed, flipping Quackity over and pushing into the ground. “And I wish you stayed that way.” Quackity muttered tears rolling down his face.

Schlatt got off of Quackity as his eyes widened. He was right. Everyone did want him dead. He may have hated Quackity, but they were friends once. Even his own friend wanted rid of him. “You didn’t mean that. Right?” Schlatt looked at Quackity, not a word coming out of him. “Tell me you didn’t mean it!” He shouted tears outlining his face. “I did mean it, okay!” Quackity screamed looking up at Schlatt. Schlatt gasped, turning away from him. “I wish I stayed that way too….” Schlatt whispered, running from Quackity yet again. “Schlatt! No!” Quackity yelled, his voice getting softer and softer the further Schlatt ran.

“Phil! Phil!” Quackity called, running out of the forest with a stream of tears coming down his face. “Quackity!? Where’s Schlatt?” Phil said with confusion, pulling out his sword. “I-I didn’t know he was alive…. look I’m sorry, but you’ve gotta help me get him back.” Quackity sobbed, wiping the tears from his face. “What did you do!” Phil shouted nearing Quackity. “We got into an argument…. And he’s headed for the docks!” Quackity said, running towards Schlatt’s direction. “Wait for me!” Phil said, taking off after him. Poor Ghostbur peered out the window with worry, not understanding that Schlatt’s life was at stake.

Schlatt finally arrived at the docks. He had found a bottle of whiskey as he sat at the edge of the wooden bridge. He stared at the bottle seeing his reflection in it. “I’m sorry….” He whispered as he chugged the bottle down. He shattered the bottle in his hands making him bleed. But it didn’t hurt. He didn’t care. He didn’t care as he threw it into the murky water below. He covered his face crying into his blood and tear soaked hands. “I want it to stop! I want the pain to stop!” He cried out. He stood up looking down into the sea. Bloody handprints tattooed his face. He told himself that he didn’t deserve it. That he didn’t deserve any of it. That no one cared. That no one fucking ever gave a single damn about him! And then he jumped. Splashing into the ocean as all the pain and misery was washed away by the cold stinging water.

“Schlatt don’t!” Quackity shouted seeing his friend splash into the water. “Schlatt!” Phil shouted about to jump in after him before Quackity stopped him. “You can’t swim with your broken wings.” Quackity said with his sadness engulfing him. “But I can!” Ghostbur shouted, jumping in after him. “Wait, What!? Wilbur!?” Quackity shouted in surprise. (“How many god damn people are coming back to life” - Probably Quackity). “WILBUR!” Phil screamed, trying to grab him, but only catching air within his hands. “He’ll melt!” Phil screeched, unable to do anything.

Ghostbur felt everything around him burn, but he had to save Schlatt. He drove through the pain and opened his eyes. In the dark depths below he could just make the outlines of schlatt. He tried to call him, only to have bubbles erupt from his mouth. He covered his mouth in shock not knowing. His skin kept burning more and more, so he tried his best to hurry and get to Schlatt. Finally, reaching him he grabbed Schlatt by the waist, lifting him up through the water. Schlatt was unconscious, so it was up to Ghostbur to find the strength to save him in time. He’d remembered how kindly he had treated him. His love, his companion. Alivebur may not have taken a liking to Schlatt, but Schlatt had changed. And Ghostbur thought that was mostly due to their uncanny friendship. But he knew eventually that everything had to come to an end and as they reached the surface the world around him went to black.

Schlatt felt someone haul him out of the water as he tried to open his eyes. He looked around as everything became clearer. Blood still dripped from his hands as Phil wrapped them in some sort of cloth. He winced feeling the ok pressure being applied to his hands. He coughed up some of the sea water he had inhaled. “Quackity.” He called out mindlessly searching for him. “I’m here. I’m here.” Quackity cried softly cupping Schlatt’s hand. Schlatt rubbed away Quackity’s tears as his senses slowly returned.

“Wait, where’s Ghostbur!?” He asked in a panic. “Ghostbur!” Schlatt cried out, crawling over the edge to where Ghostbur once was. Nothing was left of the innocent ghost. Schlatt stared into the water hoping he would emerge. For a time they all waited quietly, quietly waiting for their friend. “Schlatt, this is your fault.” Phil broke the silence. “What?” Schlatt said, confused. “I said this is your fault!” Phil grabbed Schlatt by the collar. “I let you into my home! I trusted you! Will, trusted you ....” Phil mumbled his last sentence realizing what he said. “Oh, so now you're blaming me! You're the one who killed him in the first place!” Quackity gasped hearing Schlatt’s words.

Then a fist was met with Schlatt’s face. Followed by another and another. “Phil! Stop!” Quackity cried trying to pull him away from Schlatt. “You took him from me!” Phil screeched holding Schlatt over the water. “Now you’ll join him.” Phil scoffed, hatred in his voice. “Phil, don't do it! Please!” Quackity sobbed practically begging. Schlatt looked at Phil, his own blood fogging his vision. “Phil….is this what Ghostbur would have….wanted.” Schlatt asked weakly. “No….but this is what Wilbur would have.”

Phil’s grip loosened on Schlatt, letting him fall into the sea.

Myotonic muscular dystrophy (MMD): A lot of types of muscular dystrophy can also lead to heart diseases and breathing problems which would fit into Schlatt’s clinical picture. It also affects Schlatt’s use of his legs.

COPD: One of the complications of COPD that is quite relevant to our discussion is chronic heart failure - due to complications in the lungs it becomes very hard for a heart to pump blood properly so it gets weaker, blood starts flowing slower and there are a lot more chances of random blood clots forming (this could have worsened the muscle pains as symptoms like intermittent claudication are common for chronic heart failure). There is indeed a chance of having a heart attack and a stroke at the same time (or have a heart attack that manifests in stroke-like symptoms). It is called cardio-cerebral infarction. It starts with a heart attack (mostly caused by a blood clot or an atherosclerotic plaque in the heart’s arteries), as heart tissue starts to die the production of more blood clots increases and one of them may end up in the brain causing damage there. Alternatively, the brain tissue may start to die because of the general decrease of blood going into it as the heart starts dying and can’t work properly.

Withdrawal syndrome (Discontinuation syndrome): Occurs in individuals who have developed physiological dependence on drugs or alcohol and who discontinue or reduce their use of it.

Source:

#schlatt #jschlatt #tubbo myct #dsmp au #philza #philza minecraft #fanfic #ghostbur #wilbur soot #story

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nuadox · 2 years

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FDA awards 19 grants and two contracts related to rare diseases, including ALS

- By U.S. Food and Drug Administration (FDA) -

Today, the U.S. Food and Drug Administration announced it has awarded 19 new grants and two new contracts totaling more than $38 million in funding over the next four years to support clinical trials, natural history studies and regulatory science tools related to rare diseases.

These grants and contracts, which were funded by the FDA’s Orphan Products Grants Program, aim to advance the development of medical products to treat rare diseases. Several awards support the Accelerating Access to Critical Therapies for Amyotrophic Lateral Sclerosis Act (ACT for ALS) which recently established the FDA Rare Neurodegenerative Disease Grant Program to promote medical product development for rare neurodegenerative diseases such as ALS.

“One of the greatest obstacles facing individuals who suffer from rare diseases is the limited treatment options currently available,” said FDA Commissioner Robert M. Califf, M.D. “Since the beginning of the Orphan Products Grants Program in 1983, it has facilitated the approval of more than 80 rare disease products. Through this and other efforts focused on rare diseases, the FDA continues to advance the development and evaluation of safe and effective medical products that help address patients’ unmet needs.”

The FDA received 33 clinical trial grant applications and awarded more than $25 million spread over the next four years to 11 clinical trials that support product development for rare disease treatments. Seven of the awards fund studies of rare cancers, mostly targeting cancers of the brain and peripheral nerves. Visit Orphan Products Grants (clinical trials) for more information.

Natural history studies look closely at how specific diseases progress over time. The FDA received 43 natural history grant applications and funded eight new grants totaling more than $11 million spread over the next four years for natural history studies that support innovative research to inform medical product development. Several studies seek to characterize certain subgroups within a disease, identify novel clinical outcome measures and biomarkers, which have the potential to improve the current standard of care and inform future drug development, including gene therapies. Visit Orphan Products Grants (natural history studies) for more information.

The Rare Neurodegenerative Disease Grant Program was established specifically for ALS and neurodegenerative conditions upon enactment of the ACT for ALS in December 2021. The ACT requires that the FDA award grants and contracts to public and private entities to cover costs of research on, and development of interventions intended to prevent, diagnose, mitigate, treat, or cure ALS and other rare neurodegenerative diseases in adults and children. Three of the natural history studies awarded by the FDA are related to rare neurodegenerative diseases including for ALS, Myotonic Dystrophy Type 1, and Ataxia-Telangiectasia. The study for ALS, partially funded by the National Institutes of Health (NIH) has the potential to advance existing knowledge of the natural history of ALS, inform drug development and possibly support future regulatory decisions.

Additionally, the FDA funded two contracts related to rare neurodegenerative diseases. One contract, co-funded by NIH and the FDA, will study whether a physical assessment of ALS patients, typically done in a health care professional’s office, can be done remotely at home to minimize the burden on patients. This can ultimately lead to lower clinical trial costs and enable decentralized trials, where appropriate, improving access to trials for patients in rural areas and lower-resource healthcare settings.

The second contract is a landscape analysis of patient preference information (PPI) studies focused on brain-computer interface (BCI) devices. The FDA is specifically interested in BCI devices that communicate with the brain and provide patients, who are no longer able to speak or move, with the ability to interact with their families and health care professionals. The contract will review the literature to determine what is already known about BCI devices and PPI studies in ALS. In total, through collaborative efforts, the FDA and its partners were able to support nearly $6 million in research and science to advance the mission of the ACT for ALS Act. Visit Rare Neurodegenerative Disease Grant Program for more information about the contracts.

“These grants provide important funding to researchers who are working to develop better treatments for rare disease patients,” said Sandra Retzky, D.O., J.D., MPH, director of the FDA’s Office of Orphan Products Development (OOPD). “The contracts aim to advance treatment options for patients, help inform regulatory decision making, and promote diversity, equity and inclusion in clinical research. OOPD will continue to make investments in progressive studies to advance medical product development.”

Earlier this year, the FDA announced the agency’s Action Plan for Rare Neurodegenerative Diseases, including ALS – a five-year plan to further the development of safe and effective medical products and facilitate patient access to novel treatments. The plan was developed in accordance with the ACT for ALS Act. The FDA recently announced a call for comments on current funding needs in the rare neurodegenerative disease space that could be supported by grants from the Office of Orphan Products Development.

The FDA remains committed to supporting rare disease research by providing existing grantees with critical funding and encouraging innovative trial designs, collaborations among stakeholders, early and ongoing patient engagement, use of innovative methods, and use of established infrastructure.

Related Information

Office of Orphan Products Development

Developing Products for Rare Diseases and Conditions

Rare Diseases Program

Accelerating Access to Critical Therapies for ALS Act – ACT for ALS

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.

Source: U.S. Food and Drug Administration (FDA)

Read Also

FDA and NIH launch public-private partnership for rare neurodegenerative diseases

#rare disease #fda #usa #medecine #als #health #diseases

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kssdesignsandart · 2 years

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KSS intro

Best Author in Abingdon

About K.S.S Illustrations & Designs Krist-l Widner is a self-driven woman who is very much into helping people. She is a mother of a child diagnosed with Dermatomyositis a juvenile type of autoimmune rheumatoid condition. There is no cure and only hopes of remission. Bringing awareness to Juvenile dermoyomositis. I am an author promoting books through products. I am creative and different when it comes to putting pictures on items. I find being different and creative is a fun thing to do on products. I enjoy creating new and different things from paintings to writing to making products.I have been on a crusade for 5 years now. I have been taking care of a beautiful child who suffers skin rashes, fatigue, muscles, which can be tight causing her to walk on her toes. This condition is called Juvenile dermoyomositis. More info can be found at https://curejm.org/. There are times when it requires cytoxin chemo, Rituximab, and IVIG infusions to help the condition at times it begins to worsen. This brings it into control. Some books I have written for self help for families about these kind of days.There are times some can go into remission. I wrote a book called Davids special shoes. It is about a little boy who has myotonic dystrophy. He has had surgery to help him not walk on his toes. He wears braces. It is about how braces help. These two situations are an inspiration. It reminds us that anything we do or create it has a purpose and meaning. Also that if you can walk, talk, eat on your own, and always be healthy be greatful for it. Remember to see past handicaps. Some of them are the most beautiful people you run across. https://linktr.ee/kssdesigns https://www.linkedin.com/in/kristl-widner-5206b921a Books written by Krist-l Widner: http://www.amazon.com/-/e/B079QM7SRP https://artrepreneur.com/art/eTTa5gWrdYtSDPZET If you have any questions, or you would like to arrange an interview or appearance, I am available via email.

#introduces #painting #art #introducing myself

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thesunshinereporter · 7 days

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Myotonic Dystrophy Pipeline Assessment 2024 | In-depth Insights Into the Emerging Drugs, Latest FDA Approvals, Clinical Trials, Ter, Key Companies

http://dlvr.it/T5sjq0

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helthcareheven · 19 days

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Embryo Enhancement Strategies: Preimplantation Genetic Diagnosis

What is PGD?

PGD, or preimplantation genetic diagnosis, is a procedure performed on embryos prior to implantation in the womb. During in vitro fertilization (IVF), embryos are created through fertilization in a laboratory dish and are allowed to develop for a few days. At this early stage, one or two cells are gently removed from the embryo and tested for genetic abnormalities and conditions. Only healthy embryos, as determined by PGD, are selected for implantation. The History of PGD

The first baby born through PGD was in 1990 after testing for cystic fibrosis. In the years since, the technique has improved and can now test for hundreds of genetic disorders. Initially, PGD was used for serious hereditary conditions like cystic fibrosis, Tay-Sachs disease, sickle cell anemia, and muscular dystrophy. Today, it is also applied to detect chromosomal abnormalities like Down syndrome and gender selection for X-linked disorders. PGD has helped many couples avoid passing on serious genetic diseases to their children. The PGD Process

The general steps involved in PGD are:

1) IVF treatment is performed as normal to collect multiple eggs from the female patient. 2) Eggs are fertilized with sperm in the lab to create embryos. 3) Typically on day 3 of development, when the embryo contains 6-10 cells, one or two cells are gently removed for biopsy without harming embryonic development. 4) The biopsied cells are analyzed using techniques like fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR) to detect abnormalities. 5) Only healthy embryos, as confirmed by PGD results, are selected and implanted back into the woman's womb. Diseases Screened by PGD

Some of the more common genetic disorders for which PGD is often used include: - Cystic fibrosis: A lung disease caused by mutations in the CFTR gene. PGD can detect affected embryos. - Huntington's disease: A neurodegenerative condition caused by CAG repeat expansions. PGD finds embryos free of expansions. - Fragile X syndrome: The most common form of inherited intellectual disability caused by mutations in the FMR1 gene. Embryos can be tested. - Myotonic dystrophy: A muscular dystrophy caused by CTG repeat expansions that PGD can identify in embryos. - Beta thalassemia: An anemia caused by mutations in the HBB gene. PGD selects unaffected embryos. - Sickle cell anemia: Another anemia caused by a mutation in the HBB gene. PGD accurately diagnoses embryos. How Accurate is PGD?

As the techniques used for PGD continue to improve, the tests have become highly accurate. FISH analysis has an accuracy rate of about 95-99% while PCR-based methods detect abnormalities with over 99% accuracy. However, there is still a small chance of diagnostic errors. PGD is not currently able to test for all known genetic disorders and conditions either. While it has helped many couples, PGD is not perfect and misdiagnosis is still possible in a small number of cases. Continued clinical testing and experience will help further enhance the accuracy and reliability of PGD. Overall, when performed by experienced centers, PGD provides an effective method for screening embryos. Limitations and Ethical Considerations

While PGD addresses the desire to have healthy, genetically related children, it is not without limitations and ethical concerns. Aside from occasional misdiagnosis risks, PGD is not accessible or affordable for all couples and families affected by genetic disorders. The procedure is also limited to testing only those disorders with a known genetic cause and diagnostic test. There are ongoing debates around the widening scope of what conditions PGD is used for, including gender selection for social reasons alone. Some argue this could eventually lead to selecting embryos for traits like intelligence or athletic ability. Most experts agree PGD should only be offered for preventing medical disease or conditions. Overall, PGD is an advancing technology that provides benefit but also responsibility in its application. In conclusion, through the advances of preimplantation genetic diagnosis, modern science now offers new hope for couples at high risk of passing on life-altering genetic disorders. When performed carefully by trained professionals, PGD has proven an effective tool for pre-implantation diagnosis of embryos. Continued progress is still needed to further increase accuracy, expand testing options, and ensure judicious application in line with ethical standards. Looking ahead, PGD promises more couples the ability to have healthy children free of devastating genetic diseases.

#GeneticInsightPGD #EmbryoScreening #PreimplantationGenetics

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iamd-dystrophy-treatment · 2 months

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Muscular Dystrophy Symptoms In India

The muscular dystrophy symptoms in India are similar to those observed globally, as MD is a genetic disorder that affects muscle function and can manifest in various ways. The most common types of muscular dystrophy include Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and myotonic dystrophy.

Common Muscular Dystrophy Symptoms In India

Progressive muscle weakness, typically starting in the legs and pelvis

Difficulty with motor skills, such as walking, running, and climbing stairs

Waddling gait and frequent falls

Enlarged calf muscles (pseudohypertrophy)

Muscle contractures (shortening of muscles, restricting movement)

Progressive difficulty in breathing and heart function as the condition progresses

Becker Muscular Dystrophy Symptoms in India (BMD):

Similar to DMD but with a later onset and slower progression

Muscle weakness and wasting, usually starting in the teens or early adulthood

Difficulty with running and jumping, but often able to walk into adulthood

Cardiac involvement, leading to heart problems in some cases

Symptoms of Myotonic Dystrophy:

Muscle weakness and stiffness, especially in the face, neck, hands, and feet

Difficulty relaxing muscles after contraction (myotonia)

Fatigue and muscle pain

Progressive muscle wasting and weakness over time

Cardiac arrhythmias and respiratory issues in some cases

It's important to note that muscular dystrophy symptoms in India and their severity can vary widely among individuals with MD, even within the same family. Early diagnosis and intervention, along with a multidisciplinary approach to care, can help manage symptoms and improve quality of life for individuals with muscular dystrophy in India.

Visit to know in Detail about muscular dystrophy symptoms in India.

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columbianewsupdates · 2 months

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Myotonic Dystrophy Pipeline Drugs Analysis Report, 2024 Updates: FDA Approvals, Clinical Trials, Therapies, MOA, ROA by DelveInsight | Dyne Therapeutics, Avidity Biosciences, Harmony Biosciences

http://dlvr.it/T38nHM

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rockydolittle · 3 months

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Q&A with Leyla, Part 2: Vitamin B12

Any supplement recommendations for Myotonic Muscular Dystrophy Type 2?; How much B12 should a senior male take? In what form?; I’m 83 and having to take blood pressure meds every day. Any advice?; More comments on HgbA1c and blood glucose disparities.

View On WordPress

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gendronrecherche · 4 months

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Could Calcium Blockers Reverse Myotonic Dystrophy Weakness?

Calcium channel blockers display promise as a potential therapy for myotonic dystrophy type 1 (DM1). http://dlvr.it/T0vTwW

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clcpapers · 4 months

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Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model

http://dlvr.it/T0t54P

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biotechtv · 6 months

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Antibody oligonucleotide conjugates as an RNA strategy with the CEO of Avidity Biosciences

#biotechnology

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brookston · 8 months

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Holidays 9.15

Holidays

Battle of Britain Day (UK)

Born to Be Wild Day

Cantabria Day (Spain)

Capitol Hill Day

Carbon Day

Chestnut Day (French Republic)

Cry of Dolores (Mexico)

Eleven Days of Global Unity, Day 5: Health

Engineer's Day (India)

Felt Hat Day

Free Money Day

German American Heritage Month begins [until 10.15]

Google Awareness Day

Grand Magal de Touba (Senegal)

Greenpeace Day

Grito de Dolores (a.k.a. Cry of Dolores; Mexico)

Hunger Action Day

International Day of Democracy (UN)

International Dot Day

International Gotcha Day

International Hypothalamic Hamartoma Awareness Day

International Myotonic Dystrophy Awareness Day

International Sing Out Day

International Wiedemann-Steiner Syndrome Awareness Day

Knowledge Day (Azerbaijan)

LGBT Center Awareness Day

Make A Hat Day

Moonpie Day (Republic of Molossia)

National Africa Civility Day

National Brain Health Day

National Caregivers Day

National Cozy Mystery Day

National Custom Framing Day

National 8-Track Tape Day [also 4.11]

National Hispanic Heritage Month begins [until 10.15]

National Hug Your Boss (UK)

National Malcolm Day

National Muslim Voter Registration Day

National Neonatal Nurses Day

National Online Learning Day

National Ruben Day

National Tackle Kids Cancer Day

National Thank You Day

Nuestra Señora de la Bien Aparecida (Cantabria, Spain)

Oriana Fallaci Day

Pension Awareness Day (UK)

Restoration of Primorska to the Motherland Day (Slovenia)

Roberto Clemente Day

Silpa Buirasri Day (Thailand)

Someday

Tackle Kids Cancer Day

Thimphu Tshechu (Bhutan)

World Afro Day

World Chimamanda Day

World Engineers Day

World Lymphoma Awareness Day

Zombie in the Machine Day

Food & Drink Celebrations

Butterscotch Cinnamon Pie Day

Chicken Lovers' Day

National Cheese Toast Day

National Creme de Menthe Day

National Double Cheeseburger Day

National Linguine Day

3rd Friday in September

Bright Pink Lipstick Day [3rd Friday]

Chästeilet (Dividing of the Cheese; Switzerland) [3rd Friday]

Clean Up the World Weekend [Begins 3rd Friday]

Ember Day (Roman Catholic and Anglican Churches) [Friday after 9.14]

Gee Haw Whimmy Diddle Competition begins (Asheville, NC) [3rd Friday, through weekend]

Global Be(er) Responsible Day [3rd Friday]

International Grenache Day [3rd Friday]

Jeans For Genes (UK) [3rd Friday]

King Turkey Day Festival (Minnesota) [3rd Friday & Saturday]

National Black Voter Day [3rd Friday]

National Concussion Awareness Day [3rd Friday]

National Doodle Day (UK) [Friday of 3rd Full Week]

National Foot Drop Awareness Day (UK) [3rd Friday]

National POW/MIA Recognition Day [3rd Friday]

National School Spirit Day [3rd Friday]

National Sunflower Day (South Africa) [3rd Friday]

National Tradesman Day [3rd Friday]

National #WhyApply Day [3rd Friday]

PARK(ing) Day [3rd Friday]

Quarter Tense (Ireland) [Friday after 9.14]

Raspberry Day (UK) [3rd Friday]

Independence Days

Costa Rica (from Spain, 1821)

El Salvador (from Spain, 1821)

Guatemala (from Spain, 1821)

Honduras (from Spain, 1821)

Lutherania (Declared; 2006) [unrecognized]

Nicaragua (from Spain, 1821)

Occitania (Declared; 2015) [unrecognized]

Feast Days

Aicard (a.k.a. Achart; Christian; Saint)

Alpinus (a.k.a. Albinus) of Lyon (Christian; Saint)

Aprus (a.k.a. Èvre or Aper) of Toul (Christian; Saint)

Aunt Melba's Guernsey Cotillion (Muppetism)

Catherine of Genoa (Christian; Saint)

Gilles de Rais Day (Church of the SubGenius; Saint)

Goethe (Positivist; Saint)

Irish Coffee Day (Pastafarian)

James Chisholm (Episcopal Church)

John the Dwarf (Christian; Saint)

Joseph Abibos (Christian; Saint)

Ksenia Milicevic (Artology)

Kshamavani (Forgiveness Day; Jainism)

Lucebert (Artology)

Rosh Hashanah (began yesterday at Sundown)

Saint Dominic in Soriano painting (Christian; Saint)

Mamilian of Palermo (Christian; Saint)

Media Aestas IX (Pagan)

Mirin (Christian; Saint)

Nicetas the Goth (Christian; Saint)

Nicomedes (Christian; Saint)

Our Lady of Sorrows (Christian)

Roland de Medici (Christian; Saint)

Virgin Mary of the Seven Sorrows Day (Slovakia)

Lucky & Unlucky Days

Tomobiki (友引 Japan) [Good luck all day, except at noon.]

Premieres

Alice the Jail Bird (Disney Cartoon; 1925)

Almost Famous (Film; 2000)

American Beauty (Film; 1999)

Beer League (Film; 2006)

Be Without You, by Mary J. Blige (Song; 2005)

The Big Picture (Film; 1989)

The Black Dahlia (Film; 2006)

Blood & Chocolate, by Elvis Costello (Album; 1986)

Blue Train, by John Coltrane (Album recorded; 1957)

The Book of Merlyn, by T.H. White (Novel; 1977) [Once and Future King #5]

Bugsy Malone (Film; 1976)

Calliou (Children’s Animated TV Series; 1997)

CHiPs (TV Series; 1977)

Davy Crockett Goes to Congress (Disney TV Film; 1963)

Escape from Freedom, by Erich Fromm (Philosophy Book; 1941)

Everyone’s Hero (Animated Film; 2006)

Fast Times at Ridgemont High, by Cameron Crowe (Novel; 1981)

The Fighting Kentuckian (Film; 1949)

The Green Hat, by Michael Arlen (Play; 1925)

Hackers (Film; 1995)

A Haunting in Venice (Film; 2023)

Hit Me with Your Best Shot, by Pat Benatar (Song; 1980)

How to Play Football (Disney Cartoon; 1944)

How to Stop Worrying and Start Living, by Dale Carnegie (Self-Help Book; 1948)

The Invention of Morel, by Adolfo Bioy Casares (Novella; 1940)

I Spy (TV Series; 1965)

It, by Stephen King (Novel; 1986)

L.A. Law (TV Series; 1986)

The Lone Ranger (TV Series; 1949)

Lost in Space (TV Series; 1967)

Love Story, by Taylor Swift (Song; 2008)

Mechanical Animals, by Marilyn Manson (Album; 1998)

One, Two, Three...Infinity: Facts and Speculations of Science, by George Gamow (Science Book; 1947)

The Shadow Rising, by Robert Jordan (Novel; 1992) [Wheel of Time #4]

The Silmarillion, by J.R.R. Tolkien (Novel; 1977)

Some Time in New York City, by John Lennon and Yoko Ono (Album; 1972)

Sports, by Huey Lewis and the News (Album; 1983)

A Star is Bored (WB LT Cartoon; 1956)

The Sulli-Gully, by Ed Sullivan (Song; 1969)

The Sword in the Stone, by T.H. White (Novel; 1938) [Once and Future King #1]

Teen Titans: Trouble in Tokyo (WB Animated Film; 2006)

The Voyage of the Dawn Treader, by C.S. Lewis (Novel; 1952) [The Chronicles of Narnia #3]

Today’s Name Days

Dolores, Melissa, Melitta (Austria)

Dolores, Marija, Tugomil (Croatia)

Jolana (Czech Republic)

Eskild (Denmark)

Kulmo, Kulno, Kurmo, Kuulo (Estonia)

Sirpa (Finland)

Dolores, Roland (France)

Dolores, Melissa, Melitta (Germany)

Nikitas, Visarion (Greece)

Enikő, Melitta (Hungary)

Mamiliano, Maria (Italy)

Gunvaldis, Nikodems, Sandra (Latvia)

Eugenija, Nikodemas, Rimgailė, Vismantas (Lithuania)

Aslak, Eskil (Norway)

Albin, Budzigniew, Maria, Nikodem (Poland)

Jolana (Slovakia)

Angustias, Dolores (Spain)

Sigrid, Siri (Sweden)

Mykyta (Ukraine)

Delora, Delores, Dolores, Lola, Lolita (USA)

Today is Also…

Day of Year: Day 258 of 2024; 107 days remaining in the year

ISO: Day 5 of week 37 of 2023

Celtic Tree Calendar: Muin (Vine) [Day 11 of 28]

Chinese: Month 8 (Xin-You), Day 1 (Bing-Zi)

Chinese Year of the: Rabbit 4721 (until February 10, 2024)

Hebrew: 29 Elul 5783

Islamic: 29 Safar 1445

J Cal: 18 Aki; Foursday [18 of 30]

Julian: 2 September 2023

Moon: 1%: Waxing Crescent

Positivist: 6 Shakespeare (10th Month) [Goethe]

Runic Half Month: Ken (Illumination) [Day 4 of 15]

Season: Summer (Day 86 of 94)

Zodiac: Virgo (Day 25 of 32)

Calendar Changes

桂月 [Guìyuè] (Chinese Lunisolar Calendar) [Month 8 of 12] (Osmanthus Month) [Rooster Month]

#calendar #Holidays

1 note · View note

brookstonalmanac · 8 months

Text

Holidays 9.15

Holidays

Battle of Britain Day (UK)

Born to Be Wild Day

Cantabria Day (Spain)

Capitol Hill Day

Carbon Day

Chestnut Day (French Republic)

Cry of Dolores (Mexico)

Eleven Days of Global Unity, Day 5: Health

Engineer's Day (India)

Felt Hat Day

Free Money Day

German American Heritage Month begins [until 10.15]

Google Awareness Day

Grand Magal de Touba (Senegal)

Greenpeace Day

Grito de Dolores (a.k.a. Cry of Dolores; Mexico)

Hunger Action Day

International Day of Democracy (UN)

International Dot Day

International Gotcha Day

International Hypothalamic Hamartoma Awareness Day

International Myotonic Dystrophy Awareness Day

International Sing Out Day

International Wiedemann-Steiner Syndrome Awareness Day

Knowledge Day (Azerbaijan)

LGBT Center Awareness Day

Make A Hat Day

Moonpie Day (Republic of Molossia)

National Africa Civility Day

National Brain Health Day

National Caregivers Day

National Cozy Mystery Day

National Custom Framing Day

National 8-Track Tape Day [also 4.11]

National Hispanic Heritage Month begins [until 10.15]

National Hug Your Boss (UK)

National Malcolm Day

National Muslim Voter Registration Day

National Neonatal Nurses Day

National Online Learning Day

National Ruben Day

National Tackle Kids Cancer Day

National Thank You Day

Nuestra Señora de la Bien Aparecida (Cantabria, Spain)

Oriana Fallaci Day

Pension Awareness Day (UK)

Restoration of Primorska to the Motherland Day (Slovenia)

Roberto Clemente Day

Silpa Buirasri Day (Thailand)

Someday

Tackle Kids Cancer Day

Thimphu Tshechu (Bhutan)

World Afro Day

World Chimamanda Day

World Engineers Day

World Lymphoma Awareness Day

Zombie in the Machine Day

Food & Drink Celebrations

Butterscotch Cinnamon Pie Day

Chicken Lovers' Day

National Cheese Toast Day

National Creme de Menthe Day

National Double Cheeseburger Day

National Linguine Day

3rd Friday in September

Bright Pink Lipstick Day [3rd Friday]

Chästeilet (Dividing of the Cheese; Switzerland) [3rd Friday]

Clean Up the World Weekend [Begins 3rd Friday]

Ember Day (Roman Catholic and Anglican Churches) [Friday after 9.14]

Gee Haw Whimmy Diddle Competition begins (Asheville, NC) [3rd Friday, through weekend]

Global Be(er) Responsible Day [3rd Friday]

International Grenache Day [3rd Friday]

Jeans For Genes (UK) [3rd Friday]

King Turkey Day Festival (Minnesota) [3rd Friday & Saturday]

National Black Voter Day [3rd Friday]

National Concussion Awareness Day [3rd Friday]

National Doodle Day (UK) [Friday of 3rd Full Week]

National Foot Drop Awareness Day (UK) [3rd Friday]

National POW/MIA Recognition Day [3rd Friday]

National School Spirit Day [3rd Friday]

National Sunflower Day (South Africa) [3rd Friday]

National Tradesman Day [3rd Friday]

National #WhyApply Day [3rd Friday]

PARK(ing) Day [3rd Friday]

Quarter Tense (Ireland) [Friday after 9.14]

Raspberry Day (UK) [3rd Friday]

Independence Days

Costa Rica (from Spain, 1821)

El Salvador (from Spain, 1821)

Guatemala (from Spain, 1821)

Honduras (from Spain, 1821)

Lutherania (Declared; 2006) [unrecognized]

Nicaragua (from Spain, 1821)

Occitania (Declared; 2015) [unrecognized]

Feast Days

Aicard (a.k.a. Achart; Christian; Saint)

Alpinus (a.k.a. Albinus) of Lyon (Christian; Saint)

Aprus (a.k.a. Èvre or Aper) of Toul (Christian; Saint)

Aunt Melba's Guernsey Cotillion (Muppetism)

Catherine of Genoa (Christian; Saint)

Gilles de Rais Day (Church of the SubGenius; Saint)

Goethe (Positivist; Saint)

Irish Coffee Day (Pastafarian)

James Chisholm (Episcopal Church)

John the Dwarf (Christian; Saint)

Joseph Abibos (Christian; Saint)

Ksenia Milicevic (Artology)

Kshamavani (Forgiveness Day; Jainism)

Lucebert (Artology)

Rosh Hashanah (began yesterday at Sundown)

Saint Dominic in Soriano painting (Christian; Saint)

Mamilian of Palermo (Christian; Saint)

Media Aestas IX (Pagan)

Mirin (Christian; Saint)

Nicetas the Goth (Christian; Saint)

Nicomedes (Christian; Saint)

Our Lady of Sorrows (Christian)

Roland de Medici (Christian; Saint)

Virgin Mary of the Seven Sorrows Day (Slovakia)

Lucky & Unlucky Days

Tomobiki (友引 Japan) [Good luck all day, except at noon.]

Premieres

Alice the Jail Bird (Disney Cartoon; 1925)

Almost Famous (Film; 2000)

American Beauty (Film; 1999)

Beer League (Film; 2006)

Be Without You, by Mary J. Blige (Song; 2005)

The Big Picture (Film; 1989)

The Black Dahlia (Film; 2006)

Blood & Chocolate, by Elvis Costello (Album; 1986)

Blue Train, by John Coltrane (Album recorded; 1957)

The Book of Merlyn, by T.H. White (Novel; 1977) [Once and Future King #5]

Bugsy Malone (Film; 1976)

Calliou (Children’s Animated TV Series; 1997)

CHiPs (TV Series; 1977)

Davy Crockett Goes to Congress (Disney TV Film; 1963)

Escape from Freedom, by Erich Fromm (Philosophy Book; 1941)

Everyone’s Hero (Animated Film; 2006)

Fast Times at Ridgemont High, by Cameron Crowe (Novel; 1981)

The Fighting Kentuckian (Film; 1949)

The Green Hat, by Michael Arlen (Play; 1925)

Hackers (Film; 1995)

A Haunting in Venice (Film; 2023)

Hit Me with Your Best Shot, by Pat Benatar (Song; 1980)

How to Play Football (Disney Cartoon; 1944)

How to Stop Worrying and Start Living, by Dale Carnegie (Self-Help Book; 1948)

The Invention of Morel, by Adolfo Bioy Casares (Novella; 1940)

I Spy (TV Series; 1965)

It, by Stephen King (Novel; 1986)

L.A. Law (TV Series; 1986)

The Lone Ranger (TV Series; 1949)

Lost in Space (TV Series; 1967)

Love Story, by Taylor Swift (Song; 2008)

Mechanical Animals, by Marilyn Manson (Album; 1998)

One, Two, Three...Infinity: Facts and Speculations of Science, by George Gamow (Science Book; 1947)

The Shadow Rising, by Robert Jordan (Novel; 1992) [Wheel of Time #4]

The Silmarillion, by J.R.R. Tolkien (Novel; 1977)

Some Time in New York City, by John Lennon and Yoko Ono (Album; 1972)

Sports, by Huey Lewis and the News (Album; 1983)

A Star is Bored (WB LT Cartoon; 1956)

The Sulli-Gully, by Ed Sullivan (Song; 1969)

The Sword in the Stone, by T.H. White (Novel; 1938) [Once and Future King #1]

Teen Titans: Trouble in Tokyo (WB Animated Film; 2006)

The Voyage of the Dawn Treader, by C.S. Lewis (Novel; 1952) [The Chronicles of Narnia #3]

Today’s Name Days

Dolores, Melissa, Melitta (Austria)

Dolores, Marija, Tugomil (Croatia)

Jolana (Czech Republic)

Eskild (Denmark)

Kulmo, Kulno, Kurmo, Kuulo (Estonia)

Sirpa (Finland)

Dolores, Roland (France)

Dolores, Melissa, Melitta (Germany)

Nikitas, Visarion (Greece)

Enikő, Melitta (Hungary)

Mamiliano, Maria (Italy)

Gunvaldis, Nikodems, Sandra (Latvia)

Eugenija, Nikodemas, Rimgailė, Vismantas (Lithuania)

Aslak, Eskil (Norway)

Albin, Budzigniew, Maria, Nikodem (Poland)

Jolana (Slovakia)

Angustias, Dolores (Spain)

Sigrid, Siri (Sweden)

Mykyta (Ukraine)

Delora, Delores, Dolores, Lola, Lolita (USA)

Today is Also…

Day of Year: Day 258 of 2024; 107 days remaining in the year

ISO: Day 5 of week 37 of 2023

Celtic Tree Calendar: Muin (Vine) [Day 11 of 28]

Chinese: Month 8 (Xin-You), Day 1 (Bing-Zi)

Chinese Year of the: Rabbit 4721 (until February 10, 2024)

Hebrew: 29 Elul 5783

Islamic: 29 Safar 1445

J Cal: 18 Aki; Foursday [18 of 30]

Julian: 2 September 2023

Moon: 1%: Waxing Crescent

Positivist: 6 Shakespeare (10th Month) [Goethe]

Runic Half Month: Ken (Illumination) [Day 4 of 15]

Season: Summer (Day 86 of 94)

Zodiac: Virgo (Day 25 of 32)

Calendar Changes

桂月 [Guìyuè] (Chinese Lunisolar Calendar) [Month 8 of 12] (Osmanthus Month) [Rooster Month]

#Holidays

0 notes