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Fernfahrt nach Bilbao: Teil Pamplona nach San Sebastian Vollständiger Bericht bei: https://agu.li/26Q Bei schönstem und sommerlich warmen Wetter wechseln wir von der Provinz Navarra in die Provinz Baskenland. Das GPS registrierte 114.3 KM und 1528 Höhenmeter.
#Asiain#Baskenland#Ezkurra#gefühlt wie Hochsommer#Goizueta#Irurtzun#Navarra#Orokieta#Ororbia#Pagoapa#Pamplona#Saldias#San Sebastian#Sommer#Spanien#Udabe
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Luciano Goizueta
Ausencia XXIX [Hockney Splash-less], 2022
Acrylic on canvas
59 1/10 × 74 4/5 × 2 in | 150 × 190 × 5 cm
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La Fundació CNSE crida a fer de la lectura un dret, i no un luxe, per a la infància sorda
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La Fundació Confederació Estatal de Persones Sordes (CNSE) va reconèixer a cinc centres escolars de Madrid, Múrcia, Terrassa i València amb els premis del concurs estatal de contes en llengua de signes per al foment de la lectura, i va reclamar que la lectura sigui un dret, i no un luxe, per a la infància sorda…[…] (servimedia.es)
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#CEIP Santa María de Gracia#Centro educativo Ponce de León#Colegio Gaudem#Colegio Luis Fortich-IVAF#Escola El Vapor de Terrassa#Francisca García Vizcaíno#Fundación CNSE#Jesús Martín#Mohamed Rida#Nil Morera#Pablo Fernández#Roberto Suárez#Teresa Goizueta
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“Acompañamiento is defined as standing with people. It is an intentional act of being and experiencing social conditions alongside those who are impacted by these and inter-connected systems of oppression.” (Goizueta, 2009; Sepúlveda, 2011; Watkins, 2015).
— stefanie l. kaufman mthimkhulu (@stefkaufman) April 30, 2024
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Esta Navidad regala grandes historias.
“Las hijas de la criada” de Sonsoles Ónega, Premio Planeta 2023, y “La sangre del padre” de Alfonso Goizueta, finalista Premio Planeta 2023. #libreriaofican #ofican #libros #regalolibros
#libreriaofican#libros#libro#recomendamoslibros#libreriaofican.com#libreriascanaria#comerciolocal#librerías#lectura#SoundCloud
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La sangre del padre: Alfonso Goizueta
La sangre del padre es una novela histórica escrita por el joven internacionalista, historiador, podcaster y autor español Alfonso Goizueta,... http://dlvr.it/SzVCCM
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La sangre del padre: Alfonso Goizueta
La sangre del padre es una novela histórica escrita por el joven internacionalista, historiador, podcaster y autor español Alfonso Goizueta,... http://dlvr.it/SzVCCN
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Nanoparticles Treat Tumors of Deadly Brain Cancer - Technology Org
New Post has been published on https://thedigitalinsider.com/nanoparticles-treat-tumors-of-deadly-brain-cancer-technology-org/
Nanoparticles Treat Tumors of Deadly Brain Cancer - Technology Org
Using nanoparticles administered directly into the cerebrospinal fluid (CSF), a research team has developed a treatment that may overcome significant challenges in treating a particularly deadly brain cancer.
Illustrative image related to a brain cancer. Image credit: Yale University
The researchers, led by professors Mark Saltzman and Ranjit Bindra, administered to mice with medulloblastoma a treatment with specially designed drug-carrying nanoparticles. The study, published in Science Translational Medicine, showed that mice who received this treatment lived significantly longer than mice in the control group.
Medulloblastoma, a brain cancer that predominantly affects children, often begins with a tumor deep inside the brain. The cancer is prone to spread along two protective membranes known as the leptomeninges throughout the central nervous system, particularly the surface of the brain and the CSF. Leptomeningeal spread is seen in a number of primary brain tumors, as well as in brain metastases from solid tumors in the breast, lung, and other places. Because there are no anatomic barriers in the CSF to prevent further growth, these cancers can spread rapidly.
Targeting tumors in the CSF has proven difficult, in part because the fluid rapidly cycles through the central nervous system about four times a day in humans, typically flushing away anti-tumor drugs before they’ve had a chance to accumulate and have any effect.
“It’s like a waterfall system, with a fast, rapid fluid flow,” said Minsoo Khang, lead author of the study and a former graduate student in Saltzman’s lab.
To overcome this obstacle, the research team fabricated nanoparticles that adhere to tumors. Designed in Saltzman’s lab, these nanoparticles are made with degradable polymers that slowly release a DNA repair inhibitor, talazoparib, which is FDA-approved and currently used in the clinic for a number of cancers. The drug is one of a relatively new class of cancer drugs known as PARP inhibitors, which block an enzyme that helps repair DNA. Without the ability to repair their DNA, tumor cells are more likely to die.
The nanoparticle treatment is injected intrathecally – that is, it’s delivered directly between the leptomeninges protecting the CSF. Over a period of weeks, the researchers detected the presence of the nanoparticles in the CSF for as long as 21 days after a single dosing.
“We were very excited to have found a medium that has long-term retention in this fluid space, which is otherwise challenging,” Khang said.
Treating brain cancers in general is challenging since few treatments can penetrate the blood-brain barrier, a natural defense system that can block potentially helpful drugs. The research team’s method could offer a solution.
“There’s been very little work on intrathecal delivery of nanoparticles, so we’re very excited because it can allow us to go after the leptomeningeal spread of disease from brain metastases,” said Bindra, the Harvey and Kate Cushing Professor of Therapeutic Radiology and Professor of Pathology. “This has really opened up an entirely new way to treat these patients, although much more work needs to be done.”
Using the nanoparticles to target the tumors allowed the researchers to use the drug talazoparib, which has proven to be effective in a number of solid tumors outside of the brain. Because the drug has limited to no penetration of the central nervous system, however, an orally delivered dose would have limited efficacy against tumors with leptomeningeal spread.
“By encapsulating it in a nanoparticle and directly injecting it into the CSF, we now get very high exposure in just that area,” said Saltzman, the Goizueta Foundation Professor of Biomedical Engineering, Chemical & Environmental Engineering & Physiology, and a member of Yale Cancer Center.
Delivering the drug intrathecally also avoids injecting it directly into the brain, a technique referred to as convection-enhanced delivery. This very challenging procedure can be performed only a few times a year. Intrathecal injections, in contrast, are much less invasive and can be given without a hospital stay.
“This is huge for us, because now we can do multiple nanoparticle treatments over time,” Bindra said.
In addition to the nanoparticle injection, mice were also given an oral dose of a chemotherapy drug known as temozolomide.
“It’s a new platform where we can give these oral chemotherapies that get across the blood-brain barrier and a targeted agent just in the central nervous system,” Bindra said. “In essence, this compartmentalization of combination therapy will enhance synergistic tumor cell killing while minimizing systemic toxicity.”
The mice that received the nanoparticle-based treatment lived significantly longer than the mice who received drug therapy that didn’t use nanoparticles and even longer than the mice that received no treatment. Further, there was much less cancer spreading in the mice that received the drug-carrying nanoparticles.
The researchers said the next steps will be to validate the approach in larger animal models, eventually followed by human testing. The team also plans to test the treatment method on other cancers, particularly those that tend to spread to the brain.
Source: Yale University
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#amp#approach#barrier#Biotechnology news#blood#blood-brain barrier#Brain#brain cancer#brain tumors#Cancer#cancer drugs#cell#Cells#chemical#Chemistry & materials science news#chemotherapy#Children#defense#Disease#DNA#DNA repair#drug#drugs#engineering#Environmental#enzyme#FDA#Featured life sciences news#Foundation#growth
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Ceo Coca Cola
Roberto Goizueta
Cuando llego a Coca Cola, habia un monton de Parásitos que recibian sueldo, con el siguieron recibiendo su sueldo pero nunca los volvio a usar, hizo de cuenta que no existian en la empresa y uno a uno empezaron a renunciar, se quejaban de que no los tenian en cuenta para nada......!!!
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La sangre del padre de Alfonso Goizueta: Finalista Premio Planeta 2023
La sangre del padre, destacada obra de Alfonso Goizueta Alfaro y finalista del Premio Planeta 2023, nos sumerge en la épica vida de Alejandro Magno. Con la abrupta pérdida de su padre, Alejandro es catapultado al trono macedonio, heredando un propósito monumental: recuperar tierras griegas de manos persas y restaurar la libertad de su gente. Sin embargo, impulsado por un destino grandioso y la sangre de héroes que corre por sus venas, sus ambiciones van más allá. Sueña con conquistar emblemas de poder como Babilonia y Persépolis y enfrentarse al imponente rey Darío del Imperio persa. Pero más allá de las batallas externas, Alejandro libra un conflicto interno, un desafío personal de introspección y autoconocimiento. "La sangre del padre" es una odisea de poder, destino y los sacrificios que conlleva la verdadera libertad, mostrando el complejo ser que fue Alejandro Magno.
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Events 7.10 (before 1900)
138 – Emperor Hadrian of Rome dies of heart failure at his residence on the bay of Naples, Baiae; he is buried at Rome in the Tomb of Hadrian beside his late wife, Vibia Sabina.
645 – Isshi Incident: Prince Naka-no-Ōe and Fujiwara no Kamatari assassinate Soga no Iruka during a coup d'état at the imperial palace.
988 – The Norse King Glúniairn recognises Máel Sechnaill mac Domnaill, High King of Ireland, and agrees to pay taxes and accept Brehon Law; the event is considered to be the founding of the city of Dublin.
1086 – King Canute IV of Denmark is killed by rebellious peasants.
1212 – The most severe of several early fires of London burns most of the city to the ground.
1460 – Richard Neville, 16th Earl of Warwick, defeats the king's Lancastrian forces and takes King Henry VI prisoner in the Battle of Northampton.
1499 – The Portuguese explorer Nicolau Coelho returns to Lisbon after discovering the sea route to India as a companion of Vasco da Gama.
1512 – The Spanish conquest of Iberian Navarre commences with the capture of Goizueta.
1519 – Zhu Chenhao declares the Ming dynasty's Zhengde Emperor a usurper, beginning the Prince of Ning rebellion, and leads his army north in an attempt to capture Nanjing.
1553 – Lady Jane Grey takes the throne of England.
1584 – William I of Orange is assassinated in his home in Delft, Holland, by Balthasar Gérard.
1645 – English Civil War: The Battle of Langport takes place.
1778 – American Revolution: Louis XVI of France declares war on the Kingdom of Great Britain.
1789 – Alexander Mackenzie reaches the Mackenzie River delta.
1806 – The Vellore Mutiny is the first instance of a mutiny by Indian sepoys against the British East India Company.
1832 – U.S. President Andrew Jackson vetoes a bill that would re-charter the Second Bank of the United States.
1850 – U.S. President Millard Fillmore is sworn in, a day after becoming president upon Zachary Taylor's death.
1877 – The then-villa of Mayagüez, Puerto Rico, formally receives its city charter from the Royal Crown of Spain.
1882 – War of the Pacific: Chile suffers its last military defeat in the Battle of La Concepción when a garrison of 77 men is annihilated by a 1,300-strong Peruvian force, many of them armed with spears.
1883 – War of the Pacific: Chileans led by Alejandro Gorostiaga defeat Andrés Avelino Cáceres's Peruvian army at the Battle of Huamachuco, hastening the end of the war.
1890 – Wyoming is admitted as the 44th U.S. state.
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"We became uncompetitive by not being tolerant of mistakes" - Roberto Goizueta
"Be happy with this fun Free Stuff In My Bio"
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"We became uncompetitive by not being tolerant of mistakes" - Roberto Goizueta
"Start a day of happiness and get free stuff In my Bio"
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"We became uncompetitive by not being tolerant of mistakes" - Roberto Goizueta
"Enjoy your day and get free stuff In my Bio"
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What are the best MBA schools to apply to with a low GMAT (550-600)?
A low GMAT score (550-600) can limit your options for top MBA schools, but there are still some excellent programs that you can consider. Here are a few MBA schools you can apply to with a low GMAT score:
University of North Carolina at Chapel Hill - Kenan-Flagler Business School: The school has a strong focus on teamwork and leadership, and its MBA program ranks among the top 20 in the US.
Emory University - Goizueta Business School: The school has a focus on global business and offers a variety of MBA programs, including full-time, evening, and weekend options.
Texas A&M University - Mays Business School: The school offers an MBA program that focuses on leadership, teamwork, and entrepreneurship, and has a strong network of alumni.
University of Arizona - Eller College of Management: The school offers a variety of MBA programs, including a full-time program and a flexible executive MBA program.
Temple University - Fox School of Business: The school offers a full-time MBA program and a part-time MBA program, and has a strong focus on entrepreneurship and innovation.
It's important to note that while a low GMAT score can limit your options, it's not the only factor that business schools consider. Admissions committees also look at your work experience, academic record, essays, and letters of recommendation, among other factors. So, if you have a low GMAT score, focus on highlighting your strengths in other areas of your application. Additionally, you can consider taking GMAT prep courses and retaking the exam to improve your score.
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