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botanybulbasaur · 5 months

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Schneider's family ; The significance of Marian

REVERSE 1999 SPOILERS AHEAD : FOR CHAPTERS 1 AND 2 ! Please tread carefully and make sure you only read about what you're willing to know.

I know we're all still completely in shambles from Chap. 2, but I wanted to make a speculation about Schneider-- and a comment about how well she's written !

Let me start with this: In many pieces of media, viewers, listeners and readers alike are told that a character has people they care for. They're told a character has a lover, a wife, kids, a family, a sister. We're told the same about Schneider: that she has 11 older siblings, and that she works in the mafia to support them.

However, it's very rarely that we're given a name and a face for these supposed loved ones. And even rarer is it that they're written well, not just as a ploy for empathy, but as their own character: Ladies, gentlemen, and esteemed guests: I present to you, Marian.

Marian is one of my favorite characters just as a stand-alone: she's realistic, she's anxious, she clings to Schneider like a lifeline-- but she's brave, too. I'd love to do an in-depth analysis on her another time, but we're here for another reason.

Marian, first of all, shows us what Schneider's family is like. How they were raised, what they believe in, who they depend on. Soft topic, I know, but as someone of Italian lineage, it's very important to me that I point this out: Marian is extremely religious.

Immigrants of every kind tend to be religious. It gives them much more faith than they ever could have: a new lifeline. They managed to make it across such a winding sea? Oh, thank the lord. They haven't been kicked out of the Americas for emigration? Thank you, holy one. There's so many more reasons for this than "they need something they don't have"- maybe the fact that the rendition of god in every religion is said to love everybody, not just those who were born into wealthy families with the bluest eyes and the blondest hair.

When in a moment with no reason, and all different kinds of desperate measures being needed.. Schneider does what her family coaxes her to. She prays.

(I can't find a screenshot, but please refer to the iconic "I didn't know you prayed" scene, and the screenshot directly below this sentence.)

I also want to point out a large difference between Schneider and her family: Schneider's perspective on a 'god' differs so, so much from her family's.

She looks to whoever may be above, in her world, scornfully-- at least, in the present day. In her past, there is a particularly impactful line I want to debunk.

"The god there ... loves the world." Schnider's family seems to believe that god was the one guiding them, the one who will forgive them-- Schneider believed that it was a whole different entity. This kid believes that the god in Sicily, whoever they may be, does not love the world-- and mio dio, if that's not fucked up, I don't know what is.

And, when Schneider comes to America and sees that shit isn't as it's cut off to be, she's resentful of whoever this god may be. She gives a pray as her last bet-- what her family wants.

And it's not that she doesn't believe in this god-- no. She just doesn't believe they love her.

"Finally forgive me" -- Finally being the key word here. She's lived all her life never being treated to mercy or being 'forgiven for her sins' -- and at her most fragile, exposed moment, she relents to what her family has taught her. To what she truly believes-- to Sicily, to Marian, her sorella. Maybe even all 11 sorelle and her parents.

And, again, they're different at face value. Marian is calm, kind. She dresses modest and has her hair grown out: she's timid, too, not befitting of a mafia boss. She's different from her younger sister.. but she's still important. She shows us another side of Schneider: and, more importantly, she shows us what-- no, who Schneider is fighting for.

Marian provides us with extremely beneficial background context of where Schneider comes from-- and, in that process, gives many of us someone to empathize with. Yes, I too know somebody at least a little like her. You do too, likely.

Maybe, you're even like Schneider-- maybe she's someone you'd aim to protect.

,,aaand that's the little lore rant. Whew! Now to study for my math finals. I hope you have a good day :)

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only-angel-28 · 8 months

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1999 part three

another long one LMAO SORRY💀💀

this one’s a trip so get ur snacks, drinks and one direction pillows and blankets from 2014 because this one’s a trip🤭🤭

lmk how we feel abt this part and ur fav moments, enjoy!!

warnings: angst, blood, underage drinking, violence, swearing

1999, part one

1999, part two

1999, part four

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Conrads pov

in…out

in…….out.

I clench my hands into fists to stop them from shaking. I shut my eyes as tight as I can to stop the tears from flowing out.

in…out

in………out.

Calm down Conrad.

she’s upset, she’s tired. it’s fine.

no, it’s not, you did this to her, you’re the problem here. you made her cry. you might as well be like that guy she was with.

That guy.

Dean.

I slowly shut Y/n’s door behind me and race to my car, ignoring Mom and Laurel’s worried exclamations.

“Everything’s fine, she’s okay, she’s sleeping right now. I just- I need to do something. I’ll be back soon.” I assure them quickly before grabbing my car keys and making my way outside.

calm down Conrad.

the only person who could calm me down right now is Y/n. I smile softly as she enters my thoughts but that smile quickly drops as I think of how she was crying tonight.

Dean.

My hands clench the steering wheel until my knuckles turn white.

She wouldn’t want you to do anything.

But the way she was sobbing in my arms…

Fuck this.

I turn the ignition on and start reversing to the main road before my car even has a chance to warm up. I drive for what seems like seconds and go to the place where Jere told me he saw Dean last after I drove Y/n home.

It feels like my entire body and mind are on autopilot. I don't even realise what I'm doing before Dean opens Thérèse’s house’s door and my fist connects with his jaw. I don't realise how much anger I had in myself until he falls backwards and I don't give him a chance to get up. I keep punching him again, and again, and again. I don't stop until the blood from his nose is dripping to his white tee, until it's all disfigured and there's more bruises on his face than the hickeys on his neck.

“You ever lay your filthy hands on her again and I’ll make sure you wish you were never born asshole.”

I keep walking to my car as Dean and Thérèse scream threats back at me and flip them off as I get inside and drive back home.

I make it back home and immediately go to Y/n’s room to check if she’s asleep yet.

God, I'll never forgive myself for hurting her like that.

I gently cover her with the duvet on the end of her bed and kiss her softly on the top of her head.

When I make my way out of her room and quietly shut her door behind me walking to the living room, mom and laurel are already waiting for me. I don't say anything as they take me in their comforting arms and hold me. It feels like they're holding me up as my body racks with sobs, threatening to give out at any second.

“I just…I just didn't want to hurt her I didn't know what to do I-” My sentence gets broken off as another sob escapes me and Laurel kisses the top of my head. “I didn't know what to do after you got sick and it got worse I’m sorry I'm so-” I say to Mom struggling to breathe as she shushes me and wipes my tears away.

‘I’ll be okay Connie, I’ll be alright.” she whispers smiling softly but the tears in her eyes tell me otherwise.

They hold me, letting me cry for what feels like hours until their words of sweet nothings and assurances blur out and my eyes get heavy.

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Y/n’s pov

“No, it’s not Jere you don't need the cover that's just for decoration. No trust me I know Bels, I've seen Gordon Ramsey do this like a thousand times on tv.”

Stevens's earsplitting voice breaks me out of the trance of sleep.

How can he be this loud so early?

What time is it?

I pull the blanket off me and start making my way to the kitchen where all the voices seem to be coming from.

Wait…blanket? I don't remember putting one on after Conrad left.

My heart drops to my stomach as I think of him.

My thoughts spiral my mind starting to overwhelm me until Stevens's voice pushes them away. Thank God for his optimism.

“Alright you guys ready?” he says optimistically at the two unsure teenagers next to him, “Stop looking at me like that Jere. Okay, 3…2…..1!” he shouts as he presses ‘blend’ on the blender without a lid and just as he does, all the ingredients in the blender splatter all over the kitchen walls.

“STEVEN!”

“OH MY GOD MAN!”

Jere and Belly shout at Steven as he looks around in a worried state at the mess he's made in the kitchen.

“Hey, what are you guys doing?” I laugh as I take a seat at the kitchen island.

“We were trying to make my legendary miracle hangover smoothies but since Steve-o here wanted to be a masterchef so bad he can take over and clean while Belly and I do it properly.” Jeremiah says as he throws Steven a kitchen towel and starts getting more ingredients out to make the smoothie again.

Belly comes up behind me at the kitchen counter and hugs me tightly, “Hey, we heard about what happened with Dean. I’m so sorry, he was a rat anyways. And Thérèse too.”

“Yeah, totally he was a dick.” Jeremiah agrees as he hugs me after Belly. “You deserve better Y/n.”

“God, when Mom told us I was ready to break all this guy's bones for messing with my baby sister and I swear I would’ve if Conrad hadn’t already beat me to it.” Steven says as he bins a chunk of fruit.

I laugh until I fully process what he’s said, “Wait what? Conrad did what?” I exclaim as worry starts to creep up on me and I get off the stool to find Conrad.

“Oh yeah, you didn't know? He's in the living room!” Jere shouts after me and I mumble a ‘thanks’ in response, too distracted trying to find Conrad.

I find Conrad fast asleep on the couch with his hair in his eyes. I sit next to him and brush the hair away from his face. I notice his knuckles peeking out from under the throw and I pull it away to show the entirety of his cut up hands. I gasp as I see them and hold them immediately examining them closely to see how deep the cuts are.

“M’fine I swear. You should see the other guy.” A raspy voice interrupts my thoughts and I look up to see Conrad looking at me sleepily.

“You didn't have to do this Connie.” I say, upset that he hurt himself over me.

“What, you think I’m gonna let the guy who hurt my girl walk around all fine? Had to fuck him up a little at least.” he smiles with his eyes closed.

I blush at him calling me ‘his girl’ although the words make my chest feel heavier.

Why wasn’t I his girl before?

I push the anxious thoughts away as he speaks to me.

“I’m really sorry about yesterday Y/n, I shouldn’t have tried to kiss you after you broke up it was shitty I’m sorry.” he says regretfully.

“It’s okay Connie don't worry about that right now,” I smile at him, “how much do your hands hurt?”

“Not that much. I could use a kiss though.” he smiles playfully.

I laugh and peck his knuckles carefully. One, two, three, fou-

Conrad lets out a loud hiss and furrows his brows in pain. Worry runs through my entire body as I ask him if I hurt him frantically. He bursts out in laughter at my reaction and tries to get off the couch.

“Oh, you dick.” I say as I push him down the couch and smile to myself as I walk away.

“I’m sorry, I’m sorry! Come back baby!” he shouts behind me in laughter.

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timeskip to the beach

“Whoo! Yeah, let’s go Jere!” Steven shouts as he pushes his wet hair out his face and grabs his surfboard, getting in the water again.

“STEVEN! PUT YOUR SUNSREEN ON!” I shout at him knowing it's pointless and he’s just going to ignore me and get sunburnt again. Every year, I smile to myself rubbing sunscreen on my arms.

I look out into the distance and see Belly trying to surf but drastically failing, Jeremiah trying to help her and Steven trying to get Jere to watch his ‘new cool trick’.

Poor Belly. She’ll never get a moment alone with Jere at this rate.

“You’re not going to surf?” Conrad says as he comes up next to me.

“I don’t know, I’m not really feeling like surfing today, might just sit here and read.” I say smiling up at him trying not to look down at his naked chest.

He nods and puts a cigarette in his mouth, reaching into his pocket to light it up.

“You’re gonna slowly kill your kidneys like that Con” I say as I look in disgust at the thing in his mouth.

He smiles down at me as he goes to light it up but stops and takes the cigarette out of his mouth before putting it back in his pocket. “Well good thing I only need one kidney to survive.”

“I’d prefer if you had two.”

He laughs at me before making his way to the waves with his board.

“CON!” I yell after him.

He turns back and looks at me questioningly as I hold up the sunscreen in my hand.

He trudges back to me complaining about the smell and slightly sticky feeling of it as I rub it all over his back and chest trying not to blush.

I make my way up his collarbones, to his neck and finish with his face. I brush his hair out his face before smiling and whispering saying, “There. All done.”

He stares down at my lips and I stare at his as we lean closer, my heart beat speeding up by the second. His hand comes up behind my neck inching our faces closer and closer-

“Hey Con you coming?!”

ugh. Steven.

Conrad and I break away quickly before Steven has a chance to see anything and I awkwardly pat him on the back. “Yep. All done.”

“Did I interrupt something?” Steven asks, sensing the tension around us.

“Nope. Not at all.” I smile at Steven and see Conrad glare at Steven out of the corner of my eye. If looks could kill…

I stifle a laugh as I see Belly giggling at the scene.

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timeskip to car

We’re driving home with “Keep Driving” playing on the radio and Conrad’s hand holding mine.

Holding each other's hands like this has been a habit of ours for years, it’s just a comfort thing.

“Hey have you guys heard about that party going down tonight at Emmy’s house?” Jere says looking at his phone from the backseat.

A couple of no’s are heard from almost everyone until Belly says, “Should we go?”

“We don’t really have anything better to do” shrugs Jeremiah.

“Alright then. It’s a plan.” Belly smiles before we all start screaming the bridge in ‘Keep Driving’.

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at the party

Conrad and I walk in together hand in hand and go to sit on one of the couches after meeting Emmy.

We talk for a bit until we decide to get some drinks in the kitchen. We’ve never really been “party people” unlike Jere, Steven and Belly, so Conrad and I always stuck together in these things. We’d just stand or sit in some corner (with a pet if there were any) and we’d talk about anything and everything while enjoying the free alcohol.

“Thank you my good sir.” I joke, accepting the drink Conrad gave me as we make our way back to our couch. “Hey you know what we should do?” I say enthusiastically smiling at him.

“Uh-oh. What?” he says taking a sip of his drink.

“We should get tattoos. You and me. Matching ones. Emmy’s cousins upstairs and she’s got a tattoo gun, Belly was telling me.” I grin.

“For real?” Conrad asks.

“Yes Connie, I mean we promised we’d get our first tattoos with each other when we were younger so why not right now?” I ask standing up and downing my drink, holding my hand out expectingly.

There’s a pause before Conrad says, “Our moms would kill us.”

“Who says they have to know?” I smile mischievously at him as he says “Fuck it.” and grabs my hand pulling me upstairs, our drinks and couch long forgotten.

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timeskip

“Holy shit this is badass!” I gasp as I see the two tiny ivy leaves on the side of my ribcage. “I’m so glad I wasn’t one of those people who cry when they get their tattoos.” I said to Conrad who was getting his matching leaves on his left shoulder. “Please, you didn’t cry but you sure as hell crushed my hand.” he says, shaking his hand around before I grab them and kiss them.

“I’m gonna go put a little lotion on this it’s starting to sting, will you be okay here?” I say to Conrad and go to the bathroom across the hall after he nods.

I put some lotion on the tattoo and immediately feel better until someone barges in.

Thérèse. Of course.

“Don’t you know how to knock?” I say, trying to turn away from her but she stops me.

“We need to talk Y/n.”

“Excuse me? No way Thérèse. No fucking way.” I say trying to open the door behind her but she’s too quick and locks it before standing in front.

“Thérèse what the fuck?!” I exclaim, starting to get mad now.

“Just hear me out. Give me five minutes to explain myself. Please Y/n.” she says and I can feel the guilt and regret seeping out of her.

I don’t want to hear a single word from her no matter what she has to say but if listening to hers my only way out of this bathroom then…

“Fine. Two minutes.” I say and immediately see the relief on her face.

“I want you to know how sorry I am. I got jealous of you and Dean like insanely jealous and I…I guess I just wanted to be with him and I didn’t think you were good enough for him and I know how stupid this sounds but I swear I’ve ended things with him and I just want our friendship back Y/n. I’m so sorry.” she says and when she finishes, she looks like she’s on the verge of tears.

I repress the small part of me that wants to take her back and be friends again out of pure respect for myself.

“I feel sorry for you Thérèse, I really do but no. I’m sorry but no, I don’t need shitty friends like you. If you liked Dean before we started dating you should’ve told me rather than making out with him and being a bitch to me when I saw you. Like I said the other night, you two assholes deserve each other. Now move.”

I’m walking back to the room Conrad was in trying to forget the interaction with Thérèse, trying to focus on just having fun with my friends and Con until a tall figure stands in my way.

No fucking way. What is everyone’s obsession with getting in my way tonight?

“Get the fuck away from me Dean.” I spit his name out.

“Babe I’m sorry, I fucked up please just-“ he tries to grab my hands and I immediately stomp on his feet.

“I said get the fuck away from me asshole!” I scream in his face before he stops wincing and quickly grabs me and pins me on the wall.

He looks at me with pure anger and possession in his eyes, scaring me to the bone.

What he says next has my fist flying straight into Dean’s jaw.

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Conrad’s pov

I step out of the room as soon as my tattoos done to show Y/n before I see her pinned against a wall by…Dean.

Anger rises in my body until I can’t think straight but before I can say a single word Y/n’s fist connects with Dean’s.

A chill runs down my spine and I swallow back the acid that crawls up my throat at her cry.

He tests his jaw, rubbing at the place she hit him. “You fucking…”

I see red as I lunge for Dean, but my attention shifts when Y/n lets out a whimper.

“Ow.” A single year runs down her face as she checks her fist.

I don't think as I jump into action. She hisses at me when I try to assess her hand, all while she swipes the tears off her face with her non-injured hand. Something definitely doesn't look right with her pinkie, and she winces as I lightly run my finger over it.

"That doesn't feel too good-" Y/n curses as she brushes her thumb across her knuckles.

"That's what you get for thinking you could lay a hand on me."

I swear this guy has a death wish.

"Oh, I'd like to lay more than a hand on you, you evil fucker.”

Y/n tries to step around me, but I block her path.

"I'll handle this." I give her other hand a reassuring squeeze.

Her brows pull together as she shuts her mouth.

"I was coming here to check in on her and see how she was holding up after seeing me and Thérèse. I'm sure it can't be easy seeing how she’s never going to be good enough for anyon-"

Bone crunches beneath my fist as I slam it straight into Dean’s nose. A deep sense of satisfaction fills me as his head rears back, rolling with the momentum of my punch. Blood gushes down his face and drips onto the carpet.

He tries to staunch the bleeding, but nothing seems to work.

“Call me when you get bored of him Y/n." Dean laughs.

Something dark takes over me. "Get out!" I roar as I lunge at him. My fingers grip onto air as he stumbles backward, tripping over his shoes as he holds his head back.

The pressure in my chest doesn't lessen as he disappears through the double doors. Hopefully he returns to whatever corner of hell he crawled out of before I have a chance to get my hands on him again.

Y/n huffs. "Well, that didn't go exactly as expected." I turn around, finding her hand clutched to her chest. Her twisted expression has my blood rushing to my ears.

I shake my head at her and say, “You’re mad." I laugh softly.

She laughs before wincing at the hand pressed against her chest. "Ouch."

"Let me have a better look." My pulse quickens as I assess her injury. I'm careful not to touch the skin near her knuckles,keeping mind of the swelling. It doesn't look like an open fracture so at least that is good news.

"You're insane. There's no other explanation for why you would punch someone in the face without knowing how."

"I thought it would be like the movies." She finches as she checks out the damage.

"We need to get you to the hospital to have it checked out" I choke on the words, unable to process the reason I decide to make that call. I fucking hate hospitals.

"No! I'm fine. See!" She wiggles her fingers and recoils.

I'm hit with the urge to go find Dean but hold back.

"Why would you punch him?"

Her jaw locks together, and she looks down at her vans.

I lift her chin with my finger. "Tell me."

She sighs, and it takes an exorbitant amount of effort not to shake the answers out of her.

"Promise not to do anything illegal if I tell you?"

"No."

Her head drops. "You're not going to be happy."

"I'm never happy." Except for rare occasions. All of which she is a part of.

She looks back up at me. Her eyes have a sheen to them that has nothing to do with her injured hand.

“He told me to…”

"To what?" Every muscle in my body tenses.

"to be with him or he’d make me regret it." She looks away as if she can hide the way her face is a wreck of emotions.

I'm already halfway down the stairs, body hot to the touch and my head empty of any thoughts besides finding Dean and pummeling him into the ground.

I should have known he would try to pull off a stunt like this. Part of me had stupidly hoped he would have some sense of decency left, but it seems he doesn't have a moral bone left in his body. I underestimated just how far he would go to retain her.

Y/n grips onto my arm and tugs me back. "Wait!"

"I can't talk to you right now.”

I can't talk to anyone, let alone her.

You're the one who brought her into this mess. What did you expect? You could’ve just told her how you felt last summer and prevented her getting with Dean in the first place.

Blood heats beneath my skin. I try to shake her off, but her hold only grows more desperate.

"I need you to take me to the hospital."

I pause, seeing through the cloud of red haze blocking my decision-making. "What?"

Her misty eyes lock onto mine. "I'm in a lot of pain."

Fuck. I release a ragged breath and shut my eyes. "Jere will take you."

"Connie, I need you there. Please." Her plea is my undoing.

My plan to send Dean into a coma slips away as I shut my eyes and nod my head. "Fine. Let's get you to a doctor.”

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part three done!!

side note: i wanted them to get matching ivy leaf tattoos bc they reminded me of taylor swifts song ivy🍂🍂

again pls lmk what you think of this part and have a good day/night!!

also pls reblog bc these take me ten years to write and my friend decided to torture me by reading them out loud in a long call about aubergines🤡🤡

#conrad fisher #conrad fisher x reader #conrad fisher x y/n #fanfic #fics #tsitp #the summer i turned pretty #jeremiah fisher #belly conklin #steven conklin #conrad x reader angst #conrad x y/n angst #conrad x reader fluff #conrad x y/n fluff

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fandomshenanigans · 2 years

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Hello! And welcome to the shitshow.

Please refer to me as "Gearz" when you are requesting or just want to chat.

My main account is @chaoticgearz and I'm making this account to kind of focus more on the prompts and headcanons I might spew out.

For now, I do a few fandoms and will accept any requests regarding them.

Amongst them are:

Identity V

Genshin Impact (Though I'm not too familiar with the lore)

Don't Starve Series

Twisted Wonderland

MCYT (Characters ONLY, we don't involve the content creators here. That's just plain weird and creepy)

MHA (I have a feeling I might regret this)

Reverse 1999

Requests can range from headcanons (sfw and nsfw), short oneshots, ships, x readers, imagines and prompts of any kind, including yandere.

Crossovers are also greatly appreciated.

Though for the NSFW I won't do anything like scat, piss or straight up rape because... No. Just no.

Very descriptive gore is also a no because I get sick reading that.

Non consensual stuff can only go as far as touching and kissing.

Please for the love of god, do not ask me to do anything gross to the minors.

In exchange, ask for as much angst you want to load onto these kids. They're much more amusing this way.

Shoot me an ask or pm if you have some questions though.

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andrewuttaro · 5 years

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New Look Sabres: GM 81 - OTT - State of the Fanbase

Fan Appreciation Night takes on an angry, comedic tone lately doesn’t it? The Buffalo Sabres Marketing Department reaches out with a trivial and unexciting toy in an attempt at saying “thank you for giving us money”; and the fanbase collective bats it out of their outstretch arms in anger. I don’t know if there was a time we weren’t so cynical and angry at Fan Appreciation Night but mind you, the first full season I paid attention to was 2011-2012 so… yeah… it always sucks. This is the second to last game and it’s the very last home game. Since it’s Fan Appreciation Night and I fancy this blog a “Fan Reaction Blog” over descriptors like “smart” and “thoughtful”, I thought this would be the best game to really dive into the state of Sabres fandom. I am also going to shoot a little higher than “it’s shit.” I understand that it is pretty shitty right now but let’s all take a step back and remember we love this team like a pet. If God forbid your pet died then you would eventually get over it, but you’d be pretty broken up about it for a while I imagine. When your pet is sick you don’t say “Fuck this animal for making me feel sad!” No, you try and figure out what’s wrong with it, bring it to the vet and what not. The obvious difference here is that pets don’t make millions of dollars off of your affection for them… well most don’t. The other big difference is you don’t trade out parts of your dog to make it better. Okay, that metaphor has gone too far. I think you get the point. On Fan Appreciation Night we take on the Ottawa Senators. Their fanbase is a good comparison for our State of the Fanbase but we’ll get back to that later. The Ottawa Senators are the only team left in the National Hockey League that are so shitty that no matter how shitty the Sabres finish they will not be able to reach the depth of Sens shittiness. The Sens had 64 points in the standings going into this game while the Sabres had 72. Ottawa also started their rookie goaltender, Joey Daccord. This was a winnable game and for the first time in what feels like forever it was just that: a win.

When Anthony Duclair scored a shade over two minutes in it felt like what we have come to expect from the Sabres recently: a rout, even against some of the worst teams in the NHL. Ottawa had just demolished the Sabres 4-0 last week! Luckily that was not the story tonight. Jake McCabe drew a hooking penalty and the best Sabres 7th round pick… ever(?) Victor Olofsson smacked in a rocket from the circle 8:40 into the first period. Unfortunately, Sabres got to Sabre and Jean-Gabriel Pageau scored a response goal for the Sens a mere 30 seconds later. The score was 2-1 in favor of the visitors going into the second but now was the time for the Sabres to take over. This time Conor Sheary drew a hooking penalty and Kyle Okposo tapped in a rebound on the ensuing powerplay to even up the score a little over six minutes into the middle period. The home team was now out-shooting the opposition and the go-ahead goal came for Buffalo within three minutes. Shortly after blowing a point blank shot himself Sam Reinhart received the toughest pass possible from good buddy Jack Eichel and snuck it past the rookie netminder. Reinhart looked like all the troubles of this season melted away in giddy celebration. I’m sure he congratulated Eichel on his team-voted MVP award and one of his all-time best assists. There would be some more bullshit and penalties through the rest of the second, but this is game 81 and haven’t we discussed all the crap enough? The Sabres ran away with the game in the third. Jack Eichel got a goal of his own and it was beautiful. As if a tribute to the fun and growth we’ve seen out of the Captain this season, he got the puck from an Olofsson rebound and just outmaneuvered the Sens goalie. It was like he was going for a walk, the long way, around the crease. It was like a reverse wrap-around if that makes any sense. Eichel’s 28th of the season made it 4-2 Sabres but the Fan Appreciation festivities were not done yet. There are some goals that stand above the rest: sometimes its for how they were scored or when they were scored. Sometimes goals are special because of who scored them. Jason Pominville, Buffalo’s favorite adopted son, benefited from a poor clearance of the puck by the Sens goalie and shot it home from the boards. 5-2 Sabres and an applause for the season highlight reel. A standing ovation through another play and a commercial break from the population of Pominville for what maybe the very last time in Buffalo. The place was ripe for feels, even through the TV, and for the remainder of the game the cynicism and anger melted away off all of us. The last Sabres home game of 2018-2019 ended 5-2 for the home team.

As fun as this game was it was followed in short order by what we were expecting no matter how the game itself turned out. The Carolina Hurricanes clinched a playoff spot with their win over New Jersey. Their ten-year playoff drought is over. That means your Buffalo Sabres are now in sole possession of the longest active postseason drought in the NHL at 8 Seasons. That stat alone is worth a rant. There are lots of ways to go with such a rant on the occasion of fan appreciation night from right at the players like the idiots who ran O’Reilly out of town and now lock onto MVP Eichel, to the coaching, to the General Manager, hell some go right on up to Terry and Kim Pegula. Rant away my friends, Jeremy White let a legendary rant rip live on the air on WGR550 last week. It’s ok. It doesn’t make you a bad fan and frankly: it’s healthy. @MattyRenn on twitter wrote an open letter aimed right at the Pegulas on Tuesday and I think that about sums up that whole vein of rants pretty well. That’s worth a read if you got some frustrations to vent over at deargodwhyussports.com. Look, I’ll be writing an extensive season retrospective bonanza after this season is over and certainly there will be some reflection after Saturday’s game in Detroit but there was a quiet lesson for all of us tonight on frustration. The fan of the year wasn’t just some dude again this season: it was a 95-year-old woman named Anna Marie Szczepanski. I think that’s a very appropriate choice given the season that the Sabres are going to finish on Saturday. Anna was born in 1924. She was 46 when the Sabres came about in this chilly industrial city on the Great Lakes. She was 49 when the Sabres reached their first Stanley Cup Final. She turned 60 in the awful 1980s of Sabres history. She was 73 when Brad May scored his incredible Mayday goal to eliminate the hated rival Boston Bruins in the 1993 Playoffs. She was 75 when Buffalo made their second Stanley Cup Final in 1999 and got robbed by a team from fucking Dallas! She turned 90 during the tank years and 91 when we drafted Jack Eichel. Guess what she still is today: the Buffalo Sabres fan of the year! Apart from simply having the longevity to live to 95, Anna represents the loyalty of Sabres fans.

Yes, we don’t want to be jobbed by incompetent management, but she lived through the Scotty Bowman stint in Buffalo when a Hall of Fame Coach and Manager couldn’t even get a Cup for the Sabres! Shit sucks right now as a Sabres fan and we can debate where we are right now in the grand scheme of franchise history until the Bills win a Superbowl; but I don’t care to debate that point because through thick and thin this is our team and no degree of shittiness can stop us from the love of the Blue and Gold. The State of the Fans of the Buffalo Sabres is rough right now, probably the roughest its been in my lifetime, but there is too much promise in this core and too much skill coming down the pipeline to hibernate your Sabres support. I know Ottawa Senators fans who are more strident than ever in their support. In case you’ve missed it: just about every imaginable thing that go wrong with an NHL team short of losing the franchise has happened in Ottawa. Their owner is still carrying out toxic policies and restricting his front office to the point of uselessness. If there are fans of that franchise losing their shit day in and day out when everything possible is going wrong then I think we can manage another season out of the playoff picture. There is a lot of work to be done but we’re better than running out on these guys now. Don’t worry, I don’t think any of us ever were going to.

I tweeted at Matt Bove how can us Sabres fans go on? The snapback of other Sabres fans proclaiming loyalty made me smile. We rant our heads off, but this is home and we know it. I tweeted that expecting that kind of response. As long as we can all agree those suburban hockey dads hating on Eichel and Dahlin can eat it I think we’ll all be here again in October. That said, timing in this crazy world of hockey can surprise you sometimes. Old buried friend Matt Moulson did an interview recently talking about how the Murray-Blysma regime ruined him with no explanation. Whatever you think of Matt Moulson aside, at least we can look back on the 2017 regime change with some relief. Speaking of timing, late last week those comments Rob Ray made a decade ago about Phil Housley resurfaced; you know, the ones about Housley being a selfish jackass? I think its clear Housley has got to go but we don’t need to kick him while he’s down too. Like, comment and share this blog. I’m going to Detroit for the last game on Saturday, but no matter what I do I won’t be able to top the sign some fans hung in the 300 level at tonight’s game that read Fire Housley. That kind of plain and simple messaging is what you really dream of for a good banner/poster at a hockey game. That’s it for the Fan Appreciation Night blog: one more game left and I might just enjoy this one better than all the rest in spite of everything. Let’s Go Buffalo!

Thanks for reading.

P.S. Carter Hutton getting the Unsung Hero 2019 Player Award is some kind of irony. Both goalies fell off a cliff in January but evidently Hutton is really the locker room magic he was advertised as. My brother wants a Hutton Shirsey.

#buffalo sabres #hockey #blog #nhl

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jerrytackettca · 5 years

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Plague: One Scientists Intrepid Search for the Truth About Human Retroviruses and Chronic Disease

Judy Mikovits, Ph.D., a virologist, researcher and founding research director of the Whittemore Peterson Institute — which researches and treats chronic fatigue syndrome (CFS) in Reno, Nevada — got embroiled in controversy when, in 2009, she was the senior author on a paper which reported that a retrovirus known as xenotropic murine leukemia virus-related virus (XMRV) may play a causal role in CFS and other diseases, including autism.

Her book, "Plague: One Scientist's Intrepid Search for the Truth About Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism and Other Diseases," details her research and personal trials that arose as a consequence of her work.

"Kent Heckenlively essentially wrote it," Mikovits says, "because I write like a scientist. We wrote it using the genre of flashback. He taped hours and hours of me telling the story as he asked me questions — because he's trained as an attorney — and then he turned that into this suspense-thriller. Interestingly enough, it almost has to read like fiction because of the lawyers it took to … make sure we weren't sued."

What Are Retroviruses?

Before we go further, let's review what a retrovirus is. A retrovirus is a ribonucleic acid (RNA) virus — in other words, a virus that contains RNA encoded genes rather than deoxyribonucleic acid (DNA). Using reverse transcriptase, the retrovirus is able to transform the single-stranded RNA into a double-stranded DNA.

When the retrovirus infects a host, it integrates its DNA into the DNA of the host cell, which allows the retrovirus to replicate itself and spread through the host. As more and more cells are infected, you become increasingly sicker. Mikovits explains:

"Humans have a DNA genome. Our blueprint is DNA. Retroviruses have an RNA genome, but they also are unique in the RNA family of viruses, where their RNA genome is reverse-transcribed. That is, written backwards by an enzyme unique to retroviruses called reverse transcriptase. That enzyme writes the RNA into DNA.

Then they have another enzyme called integrase. Integrase is like a pair of scissors that cuts open your DNA and then inserts the retrovirus, which is only about 8,000 base pairs, a very, very, very small virus, 50 to 100 nanometers on an electron micrograph. That piece of DNA — called a provirus — is now in the DNA of your cells forever. Every time your cells replicate, you make more viruses."

Now, this DNA insertion has been ongoing throughout human history. According to Mikovits, about 10 percent of the human genome is retroviral in origin. These are called human endogenous retroviruses. These, however, differ in that they've been crippled in part by our DNA methylation machinery (which modulates genes expression and the human immune system — so that they can no longer make complete viruses and therefore cannot infect others.

However, when you're infected with a retrovirus such as human T-lymphotropic virus (HTLV-1), HIV HBRV or Borellia as in chronic Lyme disease and develop DNA methylation and immune dysfunction, these endogenous retroviruses begin to be expressed, and this is yet another really important finding.

HIV — One Example of a Transmissible Retrovirus

One example of a transmissible retrovirus is the HIV virus, which can cascade into the clinical symptoms of acquired immunodeficiency syndrome (AIDS). HIV was discovered in 1982, and as mentioned above, was part of Mikovits' early research work. Her book includes the history of that important discovery.

When Mikovits first began studying retroviruses, HIV/AIDS was completely unknown, but they suspected a retrovirus was at play because of how retroviruses affect the human immune system and lead to acquired immune deficiencies and cancers.

"You don't just one day get this virus and you're sick. In fact, we now know millions of people have HIV and will never develop AIDS. We talk about that in the book, because the book ultimately is one of hope that we fix HIV.

I can honestly tell you in 1999, when I was running the lab of antiviral drug mechanisms, I did not ever expect we would solve that problem. Now, AIDS patients on antiretroviral therapy are probably healthier and develop fewer cancers … than most of the rest of society."

Some retroviruses, including XMRV (but not HIV), also infect your germ cells, which means they not only cause continuous infection in your body but also transfer to your offspring.

"XMRV, the xenotropic murine (mouse) leukemia retrovirus, is the mouse-related retroviruses that cause cancer and lots of neurological diseases. Those affect the stem cells, the egg, the sperm — every cell in your body. That was one of the big 'Oh, my Gods,' about our discovery," Mikovits says.

When it comes to treatment, the key is to keep the virus silent, because when they're not, each time your cells divide you're making more retroviruses. For this, antiretroviral treatments are used, some of which will be discussed later in this article.

From AIDS to ME/CFS

After 9/11, Mikovits started working with a woman whose daughter was severely ill with chronic fatigue syndrome. "Basically, that was the first time I ever saw the disease called ME/CFS," she says.

"This person was looking at a herpes virus known as human herpesvirus 6 (HHV-6). This is a virus prominent in people with Kaposi sarcoma, [which] became associated with HIV and AIDS. Dr. Patrick Moore and Dr. Yuan Chang [discovered] that Kaposi sarcoma was actually caused by a herpes virus — then known as Kaposi sarcoma herpes virus; now, it's HHV-8.

Because the immune system is crippled, you wake up the sleeping herpes viruses. People with autism, ME/CFS and cancers have a lot of chronic active infections, so we often see the Epstein-Barr virus (EBV) associated with outbreaks of ME/CFS …

This woman introduced me to Dr. Dan Peterson and Annette Whittemore in Incline Village, Nevada, where he had been studying outbreaks of ME/CFS for probably 25 years. He said he had a bank of samples. We went up there. I met all the patients.

I interviewed them in great length and developed a hypothesis, which had actually been shown before by Elaine Defreitas, Ph.D., another scientist many years earlier …

Defreitas had isolated retroviruses from patients with ME/CFS. A doctor … named Sidney Grossberg had also isolated retroviruses from at least one patient with ME/CFS. So, the retroviral hypothesis wasn't new. Everything about it fit …

One of the most severely injured patients at that time was Whittemore's daughter, Andrea. That summer (2006), I went up there … and started studying it … I used the systems biology approach, because there's a lot of heterogeneity.

We know AIDS patients who have HIV and will never get AIDS … I interviewed patients in Peterson's office all summer and took blood, urine, saliva and all kinds of samples to isolate that virus, which is what you need to do to show it's associated with a disease."

The Discovery of Infectious Retroviruses

Eventually, she brought together several of her former and current colleagues who were world experts in HIV sequencing to look at ME/CFS. Among them was the world's leading electron microscopist, Kunio Nagashima, who has done the electron micrographs of every family of human retroviruses discovered: the human beta retrovirus, human delta virus, lenti-virus (such as HIV) and gamma retroviruses.

Working in collaboration with the Cleveland Clinic, Mikovits and her team isolated the virus and spent the better part of 2008 and 2009 putting a paper together, proving the XMRV retrovirus was infectious and transmissible and not just another crippled human endogenous retrovirus.

"To our horror, we learned these [retroviruses] could be aerosolized. This was in 2011 … That was really the first nail in my coffin. Pun intended, because the national academy member, John Coffin, Ph.D. — who had told Frank Ruscetti, 'There is no such thing as human retroviruses. Don't study them' — then made a fortune out of HIV and did everything he could to destroy me and the patients," Mikovits says.

"Prior to publication in 2009, we wrote a patent on the detection of these retroviruses, these pieces and parts as contaminants of the cell cultures, of the cell lines from which we make vaccines. After they destroyed my reputation and career and forced the retraction of our paper from [the journal] Science, Coffin turned around and wrote a patent on the detection of these viruses in contaminating cell linings and contaminating biologicals in our labs."

This PDF includes emails, letters and supporting documentation showing how the retraction of Mikovits’ Science paper was forced, after which Coffin filed his own patent for a detection method of the contaminants in cell lines used for vaccines and other biologicals. There’s also documentation detailing the scientific fraud Mikovits asserts in this interview.

Infectious Retroviruses May Contaminate Blood Supply and Vaccines

In her book, she also details how infectious retroviruses are still likely infecting many biological solutions used clinically today, such as vaccines and other therapies. To say that this is a concern would be an understatement. Children’s Health Defense discusses this, and more, in “Looking Back, Looking Forward: Cancer and Vaccines.”1 Mikovits explains:

"That was really at the heart of the big 'Oh, my God.' The worst I learned in this whole experience is how corrupt scientific journals are. In fact, Ruscetti now calls Science, that prestigious journal, 'The National Inquirer,' because they literally engineered the whole thing to destroy MEC/FS patients and any association this virus [XMRV] had with these diseases …

All of the studies showed that the control population was between 3.75 and 6.8 percent infected. When you do a study and there's evidence of infection in 6 percent of the human population, that's 25 million Americans. To put that in context, at the height of HIV/AIDS in 1995, it was 1 million Americans. It would crush our health care system if they had to pay for what they caused."

The result of Mikovits' findings was nothing short of personal devastation. Not only was her paper retracted by Science, she was even arrested for "stealing" her own lab notes. Charges were ultimately dropped, but the damage to her reputation was a done deal.

"Basically, our paper came out on October 8, 2009. It was literally like 'the shot heard around the world.' I was on the road every single day. Everywhere I went doctors were like, 'She's got it. She's got it. She's got it,' and not just with MEC/FS but also with cancer, leukemia, lymphoma, with prostate cancer.

When you start looking at the inflammatory events in the acquired immune deficiencies, with autoimmune disease, with Lou Gehrig's disease, the problem became this [retro]virus. Well, there's no single virus. There's no HIV. There's a whole family of HIVs. There's an HIV 1. There's an HIV 2. There's a strain A, B, C and D.

Why do we do influenza vaccines for this strain de jour or every year? [Because] there are strains of viruses. There are families of viruses … The second that we published this paper, we started working to get a diagnostic test for the blood supply to show it wasn't contaminated, which, in fact, it was.

Later that year, the last talk I ever gave was on a science paper that came out September 22, 2011 … That talk was basically a debate for the evidence that there are human retroviruses of the XMRV family that aren't VP62 (the infectious molecular clone, not the natural isolates of our paper).

We could show in the original paper that there was evidence of murine leukemia viruses, gamma retroviruses that were infectious and transmissible, just as we had said.

Coffin was on the other end of that debate. He said it was all a recombination event. He published a paper in 2013 saying, 'When we worked with mouse cells, they expressed a lot of pieces and parts of retroviruses. This just happened to happen in the laboratory.'

[Hence, he claimed] that's what we had isolated. [Coffin claimed] that what we were looking at were just contaminants in the laboratory. 'It's all a lab contaminant,' [Coffin said], 'You can all go home. You're safe.'"

Massive Public Health Concerns Swept Under the Rug

As one might expect, Mikovits' research caused massive concern in the professional community, because here was a newly identified, infectious and transmissible retrovirus that no one was screening for, and it was potentially contaminating 10 percent of the human blood supply. But rather than face the problem head on, it was rapidly swept under the proverbial rug.

"My mom was watching Good Morning America one morning. Across the bottom of the ticker tape said, 'XMRV all a hoax' … It was horrible. We started to realize our fake news and fake science."

Today, the blood supply is unlikely to be contaminated, thanks to a decontamination procedure developed by a California-based company called Cerus and which Mikovits proved to inactivate XMRV, rendering it noninfectious.

Other biologicals, including vaccines, however, may not be routinely decontaminated using this process, in large part because they’re not required to do so, and drug companies are not liable for vaccine-induced harm. What’s more, decontaminating the vaccine may render it ineffective.

"It won’t work. It will no longer be a vaccine … The Cerus method cleans up Ebola. It cleans up Zika. It cleans up essentially any RNA viruses, including HIV and all three human retroviruses. The Cerus system is extremely valuable to cleaning up the blood supply.

But they cannot clean up the vaccines for another reason. If they do, they prove Andy Wakefield right. They prove me right. They prove they've got 25 million Americans, who they have to support for the rest of their lives and pay damages [to] …"

The Price of Making an Unpopular Scientific Discovery

On a personal level, Mikovits has taken an enormous personal hit. September 29, 2011, she was fired from the Whittemore Peterson Institute for insolence and insubordination, and was driven into bankruptcy after being falsely arrested for stealing her own lab notes. (She never was and to this day is not in possession of her notebooks or any of the two offices full of her work done in her entire career.)

She explains her firing saying that Whittemore had been selling a diagnostic test and the director of their for-profit commercial laboratory was using federal grant funds to do that work (with full knowledge and under the direction of Annette and Harvey Whittemore), which is misappropriation of federal funds. Mikovits became aware of this in August that year, and wrote him off the grant.

"The Whittemores basically fired me immediately in an attempt … to get this scientist, Vince Lombardi, Ph.D. … to recreate the work while I was out of town and say I was a lunatic — that he’d been doing the work all along, and he hadn’t misappropriated any of the funds.

They fired me on September 29 and immediately locked down the entire university to me or my staff … The insolence and insubordination was I had refused a direct order to misappropriate federal funds, basically. I wasn't ever going to do that. The insolence I'm trying to learn not to do, because it probably would have gone a lot better for me if I didn't say 'F-you,' at the same time …

It was September 22, 2011, when I gave my last talk. They had three weeks to get a Science paper out there that would destroy my reputation in the ME/CFS community … Ruscetti had to sign that paper, or he and Sandy Ruscetti would be fired … [and] lose their entire retirement, which is 75 years.

That was one of the few times I sobbed. I was sitting in my bed screaming …It was 6 o'clock in the morning. They were on the East Coast and they needed to get this paper published fast by Science.

I called the Ruscettis and said, "Frank, they agreed to change the language. They agreed to change the title. They agreed it wasn't an association study … [they say] we didn't have a diagnostic test. Either way, the Whittemores are going to kill me because they're selling the diagnostic test.'

So Frank [Ruscetti] signed the paper. They didn't change the wording. [What they did] is pure fraud. Here, the head of the National Heart, Lung, and Blood Institute published pure fraud in the journal Science, just as two years later, Ian Lipkin published pure fraud. It is fake news. It is so corrupt, everything about it.

It's not [the researchers]. It's the top of the line. It's Dr. Tony Fauci. We're only allowed to make incremental advances. When you make a discovery of this nature, it changes all of everything. This is misogyny … This is a bunch of little boys … fighting over who gets credit, while the world dies, while you kill an entire continent.

That's why I do shows like this. Because we're going to teach doctors. When doctors understand the science — and they're coming around a lot — because the science is there. Nothing about our paper, except the sequence of the virus, has ever been wrong. We knew that in the beginning."

Individuals Infected With Retroviruses Should Avoid Vaccinations

According to Mikovits, retroviruses such as XMRV affect entire families, as it can be transmitted to your offspring. Many of these families also have children with autism, which Mikovits believes may be connected to the retrovirus. The question is, what can you do if you’re infected? For starters, Mikovits recommends avoiding vaccinations.

"Until 2011, not inconsequentially, we didn't vaccinate AIDS patients the same way. It's in the book. You don't vaccinate the immune-compromised … By definition, you have an immune system that doesn't work. Why would you vaccinate them? Why would you vaccinate somebody under 3 years old, who has an immune and detox systems that don't work?

This was the key of the RNaseL story (a genetic susceptibility not to degrade RNA viruses), of the Thompson fraudulent paper [Editor’s note: This refers to William Thompson, Ph.D., a former senior scientist at the CDC’s National Center for Immunizations and Respiratory Diseases, who confessed he conspired to cover up links found between the MMR vaccine and autism].

All they had to do was wait for black boys to be 3 years old, and they would have been able to degrade the RNA virus. That's criminal. That's beyond comprehension …

The pearl of wisdom is this DNA methylation. Keep the violent virus silent … DNA methylation has to silence them. You can't inject them in a vaccine. We're injecting millions of pieces in parts of retroviruses in every vaccine, by definition (and admission).

I am working on an ongoing cancer lawsuit that says vaccines cause childhood cancer, a lymphoma. By these same mechanisms, you've destroyed the DNA methylation machinery's ability [to silence the virus]. You've simply overwhelmed the substrate. You've overwhelmed the ability to methylate.

Every time those viruses integrate, you have a better chance at insertional mutagenesis. Don't expose anybody to human (or animal) retroviruses. Use antiretroviral therapy, which are natural products … There are lots of natural products. We published on them. Those are actually therapy for these kids.

[A 100-year-old drug called Suramin] was one of the first antiretroviral therapies for HIV … [It] worked best against the murine leukemia virus-related viruses, against the mouse retroviruses, the gamma retroviruses …

[Dr. Robert] Naviaux [professor of medicine, pediatrics and pathology at University of California San Diego School of Medicine] did a small clinical trial.2 These kids got their life back.3 They started talking again. What did Bayer do? They stopped the trial and took the drug away from everyone. Now, you can't get it …

We could help millions of people get over [autism]. But when you show cure, you know cause. That's it. I would be right … Millions of people would get their lives back, and it's all about money."

XMRV Is a Significant Threat

As mentioned, there are several different retroviruses, which are part of four viral families (delta, lenti, beta and gamma). Aside from HIV and XMRV, there's the human T-cell leukemia lymphoma virus (HTLV-1) family. There are five or six HTLV viruses, but HTLV-1 is the only one known to cause severe disease.

Human beta retrovirus is another virus associated with primary biliary cirrhosis. Many patients with MEC/FS also have family members with primary biliary cirrhosis. As for which one might be the most significant threat, Mikovits believes XMRV is among the most pressing, because while HIV is well-contained at present, XMRV is not, and it appears to play a significant role in diseases of methylation.

Disturbingly, they're now using murine leukemia viruses as vectors for gene therapy and a novel cancer therapy called chimeric antigen receptor (CAR) T-cell therapy. In other words, they're causing cancer and other retroviral illnesses.

"The same thing with Gardasil … We're causing these diseases and we know it because we're using these [retroviruses] as vectors. We don't need infectious viruses. That's one thing that's really important to know. You don't need infectious viruses if you're injecting the provirus, or the pieces and parts. You inject it, past your immunity, past your gut, past RNA cell, past everything. You bypass the immune system. They don't need to be infectious.

All you need is an envelope to cause that prostate cancer. That's a paper that was published 2013. In most of our studies, all we detected was the envelope. The envelope alone causes vasculitis … Another strain of XMRV gamma retrovirus from mice was identified by Gary Owens … associated with cardiovascular disease. This is just a nightmare that we've unleashed in our environment."

Retroviruses and ME/CFS

According to Mikovits, 6 to 8 percent of the general population are infected with infectious and transmissible XMRV-retroviruses, and in the chronic fatigue population, that prevalence shoots up to about 30 to 40 percent. As with HIV, antiretroviral therapies can be very helpful in the treatment of ME/CFS, including low-dose naltrexone.

"You have to silence the other pathogens, so taking care of mycoplasma, taking care of mold, absolutely supporting the gut microbiome [will help]," Mikovits says. "We learned with AIDS and cancer patients that if they don't have the diversity in the microbiome, just like in autism, just like in MEC/FS, it's because the retrovirus is causing leaky gut …

The nonspecific inflammation [is] the retroviruses. If you keep the gut healthy, you can heal. The primary is the diversity in the microbiome, or you can't respond to the drugs. There's a lot of hope. That's what we end the show with. There are therapies. We could fix this tomorrow. That's why I do it."

To learn more, be sure to pick up a copy of “Plague: One Scientist’s Intrepid Search for the Truth About Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism and Other Diseases,” which reads more like a fictional thriller than a nonfictional book about the science of disease.

from http://articles.mercola.com/sites/articles/archive/2018/12/09/retrovirus.aspx

source http://niapurenaturecom.weebly.com/blog/plague-one-scientists-intrepid-search-for-the-truth-about-human-retroviruses-and-chronic-disease

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jakehglover · 5 years

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Plague: One Scientist’s Intrepid Search for the Truth About Human Retroviruses and Chronic Disease

youtube

What Are Retroviruses?

HIV — One Example of a Transmissible Retrovirus

Some retroviruses, including XMRV (but not HIV), also infect your germ cells, which means they not only cause continuous infection in your body but also transfer to your offspring.

From AIDS to ME/CFS

After 9/11, Mikovits started working with a woman whose daughter was severely ill with chronic fatigue syndrome. "Basically, that was the first time I ever saw the disease called ME/CFS," she says.

I interviewed them in great length and developed a hypothesis, which had actually been shown before by Elaine Defreitas, Ph.D., another scientist many years earlier …

The Discovery of Infectious Retroviruses

Infectious Retroviruses May Contaminate Blood Supply and Vaccines

We could show in the original paper that there was evidence of murine leukemia viruses, gamma retroviruses that were infectious and transmissible, just as we had said.

Massive Public Health Concerns Swept Under the Rug

"My mom was watching Good Morning America one morning. Across the bottom of the ticker tape said, 'XMRV all a hoax' … It was horrible. We started to realize our fake news and fake science."

The Price of Making an Unpopular Scientific Discovery

That was one of the few times I sobbed. I was sitting in my bed screaming …It was 6 o'clock in the morning. They were on the East Coast and they needed to get this paper published fast by Science.

Individuals Infected With Retroviruses Should Avoid Vaccinations

All they had to do was wait for black boys to be 3 years old, and they would have been able to degrade the RNA virus. That's criminal. That's beyond comprehension …

We could help millions of people get over [autism]. But when you show cure, you know cause. That's it. I would be right … Millions of people would get their lives back, and it's all about money."

XMRV Is a Significant Threat

Retroviruses and ME/CFS

from HealthyLife via Jake Glover on Inoreader http://articles.mercola.com/sites/articles/archive/2018/12/09/retrovirus.aspx

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paullassiterca · 5 years

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Plague: One Scientist’s Intrepid Search for the Truth About Human Retroviruses and Chronic Disease

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Her book, “Plague: One Scientist’s Intrepid Search for the Truth About Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism and Other Diseases,” details her research and personal trials that arose as a consequence of her work.

“Kent Heckenlively essentially wrote it,” Mikovits says, “because I write like a scientist. We wrote it using the genre of flashback. He taped hours and hours of me telling the story as he asked me questions — because he’s trained as an attorney — and then he turned that into this suspense-thriller. Interestingly enough, it almost has to read like fiction because of the lawyers it took to … make sure we weren’t sued.”

What Are Retroviruses?

Before we go further, let’s review what a retrovirus is. A retrovirus is a ribonucleic acid (RNA) virus — in other words, a virus that contains RNA encoded genes rather than deoxyribonucleic acid (DNA). Using reverse transcriptase, the retrovirus is able to transform the single-stranded RNA into a double-stranded DNA.

“Humans have a DNA genome. Our blueprint is DNA. Retroviruses have an RNA genome, but they also are unique in the RNA family of viruses, where their RNA genome is reverse-transcribed. That is, written backwards by an enzyme unique to retroviruses called reverse transcriptase. That enzyme writes the RNA into DNA.

Now, this DNA insertion has been ongoing throughout human history. According to Mikovits, about 10 percent of the human genome is retroviral in origin. These are called human endogenous retroviruses. These, however, differ in that they’ve been crippled in part by our DNA methylation machinery (which modulates genes expression and the human immune system — so that they can no longer make complete viruses and therefore cannot infect others.

However, when you’re infected with a retrovirus such as human T-lymphotropic virus (HTLV-1), HIV HBRV or Borellia as in chronic Lyme disease and develop DNA methylation and immune dysfunction, these endogenous retroviruses begin to be expressed, and this is yet another really important finding.

HIV — One Example of a Transmissible Retrovirus

One example of a transmissible retrovirus is the HIV virus, which can cascade into the clinical symptoms of acquired immunodeficiency syndrome (AIDS). HIV was discovered in 1982, and as mentioned above, was part of Mikovits’ early research work. Her book includes the history of that important discovery.

“You don’t just one day get this virus and you’re sick. In fact, we now know millions of people have HIV and will never develop AIDS. We talk about that in the book, because the book ultimately is one of hope that we fix HIV.

Some retroviruses, including XMRV (but not HIV), also infect your germ cells, which means they not only cause continuous infection in your body but also transfer to your offspring.

“XMRV, the xenotropic murine (mouse) leukemia retrovirus, is the mouse-related retroviruses that cause cancer and lots of neurological diseases. Those affect the stem cells, the egg, the sperm — every cell in your body. That was one of the big ‘Oh, my Gods,’ about our discovery,” Mikovits says.

When it comes to treatment, the key is to keep the virus silent, because when they’re not, each time your cells divide you’re making more retroviruses. For this, antiretroviral treatments are used, some of which will be discussed later in this article.

From AIDS to ME/CFS

After 9/11, Mikovits started working with a woman whose daughter was severely ill with chronic fatigue syndrome. “Basically, that was the first time I ever saw the disease called ME/CFS,” she says.

“This person was looking at a herpes virus known as human herpesvirus 6 (HHV-6). This is a virus prominent in people with Kaposi sarcoma, [which] became associated with HIV and AIDS. Dr. Patrick Moore and Dr. Yuan Chang [discovered] that Kaposi sarcoma was actually caused by a herpes virus — then known as Kaposi sarcoma herpes virus; now, it’s HHV-8.

I interviewed them in great length and developed a hypothesis, which had actually been shown before by Elaine Defreitas, Ph.D., another scientist many years earlier …

One of the most severely injured patients at that time was Whittemore’s daughter, Andrea. That summer (2006), I went up there … and started studying it … I used the systems biology approach, because there’s a lot of heterogeneity.

We know AIDS patients who have HIV and will never get AIDS … I interviewed patients in Peterson’s office all summer and took blood, urine, saliva and all kinds of samples to isolate that virus, which is what you need to do to show it’s associated with a disease.”

The Discovery of Infectious Retroviruses

Eventually, she brought together several of her former and current colleagues who were world experts in HIV sequencing to look at ME/CFS. Among them was the world’s leading electron microscopist, Kunio Nagashima, who has done the electron micrographs of every family of human retroviruses discovered: the human beta retrovirus, human delta virus, lenti-virus (such as HIV) and gamma retroviruses.

“To our horror, we learned these [retroviruses] could be aerosolized. This was in 2011 … That was really the first nail in my coffin. Pun intended, because the national academy member, John Coffin, Ph.D. — who had told Frank Ruscetti, 'There is no such thing as human retroviruses. Don’t study them’ — then made a fortune out of HIV and did everything he could to destroy me and the patients,” Mikovits says.

“Prior to publication in 2009, we wrote a patent on the detection of these retroviruses, these pieces and parts as contaminants of the cell cultures, of the cell lines from which we make vaccines. After they destroyed my reputation and career and forced the retraction of our paper from [the journal] Science, Coffin turned around and wrote a patent on the detection of these viruses in contaminating cell linings and contaminating biologicals in our labs.”

Infectious Retroviruses May Contaminate Blood Supply and Vaccines

“That was really at the heart of the big 'Oh, my God.’ The worst I learned in this whole experience is how corrupt scientific journals are. In fact, Ruscetti now calls Science, that prestigious journal, 'The National Inquirer,’ because they literally engineered the whole thing to destroy MEC/FS patients and any association this virus [XMRV] had with these diseases …

All of the studies showed that the control population was between 3.75 and 6.8 percent infected. When you do a study and there’s evidence of infection in 6 percent of the human population, that’s 25 million Americans. To put that in context, at the height of HIV/AIDS in 1995, it was 1 million Americans. It would crush our health care system if they had to pay for what they caused.”

The result of Mikovits’ findings was nothing short of personal devastation. Not only was her paper retracted by Science, she was even arrested for “stealing” her own lab notes. Charges were ultimately dropped, but the damage to her reputation was a done deal.

“Basically, our paper came out on October 8, 2009. It was literally like 'the shot heard around the world.’ I was on the road every single day. Everywhere I went doctors were like, 'She’s got it. She’s got it. She’s got it,’ and not just with MEC/FS but also with cancer, leukemia, lymphoma, with prostate cancer.

When you start looking at the inflammatory events in the acquired immune deficiencies, with autoimmune disease, with Lou Gehrig’s disease, the problem became this [retro]virus. Well, there’s no single virus. There’s no HIV. There’s a whole family of HIVs. There’s an HIV 1. There’s an HIV 2. There’s a strain A, B, C and D.

Later that year, the last talk I ever gave was on a science paper that came out September 22, 2011 … That talk was basically a debate for the evidence that there are human retroviruses of the XMRV family that aren’t VP62 (the infectious molecular clone, not the natural isolates of our paper).

We could show in the original paper that there was evidence of murine leukemia viruses, gamma retroviruses that were infectious and transmissible, just as we had said.

[Hence, he claimed] that’s what we had isolated. [Coffin claimed] that what we were looking at were just contaminants in the laboratory. 'It’s all a lab contaminant,’ [Coffin said], 'You can all go home. You’re safe.’”

Massive Public Health Concerns Swept Under the Rug

As one might expect, Mikovits’ research caused massive concern in the professional community, because here was a newly identified, infectious and transmissible retrovirus that no one was screening for, and it was potentially contaminating 10 percent of the human blood supply. But rather than face the problem head on, it was rapidly swept under the proverbial rug.

“My mom was watching Good Morning America one morning. Across the bottom of the ticker tape said, 'XMRV all a hoax’ … It was horrible. We started to realize our fake news and fake science.”

“It won’t work. It will no longer be a vaccine … The Cerus method cleans up Ebola. It cleans up Zika. It cleans up essentially any RNA viruses, including HIV and all three human retroviruses. The Cerus system is extremely valuable to cleaning up the blood supply.

But they cannot clean up the vaccines for another reason. If they do, they prove Andy Wakefield right. They prove me right. They prove they’ve got 25 million Americans, who they have to support for the rest of their lives and pay damages [to] …”

The Price of Making an Unpopular Scientific Discovery

“The Whittemores basically fired me immediately in an attempt … to get this scientist, Vince Lombardi, Ph.D. … to recreate the work while I was out of town and say I was a lunatic — that he’d been doing the work all along, and he hadn’t misappropriated any of the funds.

They fired me on September 29 and immediately locked down the entire university to me or my staff … The insolence and insubordination was I had refused a direct order to misappropriate federal funds, basically. I wasn’t ever going to do that. The insolence I’m trying to learn not to do, because it probably would have gone a lot better for me if I didn’t say 'F-you,’ at the same time …

That was one of the few times I sobbed. I was sitting in my bed screaming …It was 6 o'clock in the morning. They were on the East Coast and they needed to get this paper published fast by Science.

I called the Ruscettis and said, "Frank, they agreed to change the language. They agreed to change the title. They agreed it wasn’t an association study … [they say] we didn’t have a diagnostic test. Either way, the Whittemores are going to kill me because they’re selling the diagnostic test.’

So Frank [Ruscetti] signed the paper. They didn’t change the wording. [What they did] is pure fraud. Here, the head of the National Heart, Lung, and Blood Institute published pure fraud in the journal Science, just as two years later, Ian Lipkin published pure fraud. It is fake news. It is so corrupt, everything about it.

It’s not [the researchers]. It’s the top of the line. It’s Dr. Tony Fauci. We’re only allowed to make incremental advances. When you make a discovery of this nature, it changes all of everything. This is misogyny … This is a bunch of little boys … fighting over who gets credit, while the world dies, while you kill an entire continent.

That’s why I do shows like this. Because we’re going to teach doctors. When doctors understand the science — and they’re coming around a lot — because the science is there. Nothing about our paper, except the sequence of the virus, has ever been wrong. We knew that in the beginning.”

Individuals Infected With Retroviruses Should Avoid Vaccinations

“Until 2011, not inconsequentially, we didn’t vaccinate AIDS patients the same way. It’s in the book. You don’t vaccinate the immune-compromised … By definition, you have an immune system that doesn’t work. Why would you vaccinate them? Why would you vaccinate somebody under 3 years old, who has an immune and detox systems that don’t work?

All they had to do was wait for black boys to be 3 years old, and they would have been able to degrade the RNA virus. That’s criminal. That’s beyond comprehension …

The pearl of wisdom is this DNA methylation. Keep the violent virus silent … DNA methylation has to silence them. You can’t inject them in a vaccine. We’re injecting millions of pieces in parts of retroviruses in every vaccine, by definition (and admission).

I am working on an ongoing cancer lawsuit that says vaccines cause childhood cancer, a lymphoma. By these same mechanisms, you’ve destroyed the DNA methylation machinery’s ability [to silence the virus]. You’ve simply overwhelmed the substrate. You’ve overwhelmed the ability to methylate.

Every time those viruses integrate, you have a better chance at insertional mutagenesis. Don’t expose anybody to human (or animal) retroviruses. Use antiretroviral therapy, which are natural products … There are lots of natural products. We published on them. Those are actually therapy for these kids.

We could help millions of people get over [autism]. But when you show cure, you know cause. That’s it. I would be right … Millions of people would get their lives back, and it’s all about money.”

XMRV Is a Significant Threat

As mentioned, there are several different retroviruses, which are part of four viral families (delta, lenti, beta and gamma). Aside from HIV and XMRV, there’s the human T-cell leukemia lymphoma virus (HTLV-1) family. There are five or six HTLV viruses, but HTLV-1 is the only one known to cause severe disease.

Disturbingly, they’re now using murine leukemia viruses as vectors for gene therapy and a novel cancer therapy called chimeric antigen receptor (CAR) T-cell therapy. In other words, they’re causing cancer and other retroviral illnesses.

“The same thing with Gardasil … We’re causing these diseases and we know it because we’re using these [retroviruses] as vectors. We don’t need infectious viruses. That’s one thing that’s really important to know. You don’t need infectious viruses if you’re injecting the provirus, or the pieces and parts. You inject it, past your immunity, past your gut, past RNA cell, past everything. You bypass the immune system. They don’t need to be infectious.

All you need is an envelope to cause that prostate cancer. That’s a paper that was published 2013. In most of our studies, all we detected was the envelope. The envelope alone causes vasculitis … Another strain of XMRV gamma retrovirus from mice was identified by Gary Owens … associated with cardiovascular disease. This is just a nightmare that we’ve unleashed in our environment.”

Retroviruses and ME/CFS

“You have to silence the other pathogens, so taking care of mycoplasma, taking care of mold, absolutely supporting the gut microbiome [will help],” Mikovits says. “We learned with AIDS and cancer patients that if they don’t have the diversity in the microbiome, just like in autism, just like in MEC/FS, it’s because the retrovirus is causing leaky gut …

The nonspecific inflammation [is] the retroviruses. If you keep the gut healthy, you can heal. The primary is the diversity in the microbiome, or you can’t respond to the drugs. There’s a lot of hope. That’s what we end the show with. There are therapies. We could fix this tomorrow. That’s why I do it.”

from Articles http://articles.mercola.com/sites/articles/archive/2018/12/09/retrovirus.aspx source https://niapurenaturecom.tumblr.com/post/180943910581

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