#kidney tissue

[introvert-celeste]

My cat Sirius isn't eating and I'm worried 😟 He's elderly (11, almost 12, years old) and not eating is a bad sign at his age. I'm hoping he's just not feeling good and that he'll get better, but at his age, I'm not sure.

#me #my cats #poor baby has had it rough for a long time #he has this condition where he gets disproportionately itchy and nothing we've done has helped #his ears and nose are basically all scar tissue #and he's been having seizure like symptoms for awhile when he gets itchy #I'm worried he has a kidney infection which is very bad for a cat #we can't take him to the vet so we're just trying to give him food and keep him as comfortable as possible #it's only been a day and a half but it's still concerning

[bpod-bpod]

Shrinking Kidneys

A sudden assault on your kidneys can be crippling and unfortunately, can also lead to chronic kidney disease if your kidneys don't fully repair. Researchers investigate why using mice subjected to two types of acute kidney injury: one that leads to tissue wasting and one that leads to repair. Fluorescence microscopy of proteins in kidney sections, alongside RNA analysis, revealed that two weeks later, kidneys undergoing wasting had more macrophages compared with kidneys undergoing repair. And these kidneys also underwent a second wave of damage caused by a build-up of immune cells that promote inflammation. Injecting antibodies to deplete these immune cells reduced tissue wasting. Without antibody injections, a month later, fluorescence microscopy of kidney sections revealed smaller kidneys following injury that led to tissue wasting (right), compared with kidneys that underwent repair (left). The persistence of macrophages after injury, therefore, promotes a pro-inflammatory environment that leads to long-term kidney damage.

Written by Lux Fatimathas

Image adapted from work by Leyuan Xu and colleagues

Department of Internal Medicine/Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, August 2022

You can also follow BPoD on Instagram, Twitter and Facebook

#science #biomedicine #kidney #kidney disease #injury #tissue repair #inflammation #antibodies #immune system #immunofluorescence

[baalzebufo]

i love my cats sm but since jules lost a bunch of weight hes like. super bony now. so hes curled around my foot and just stretched and i felt like three pointy little joints stabbing me... boy you are made of right angles... well hes purring so its okay

#hes become such a sweetheart despite having crap kidneys and weighing as much as a tissue #hes just rumbling and nuzzling my foot which is CUTE but also so pointy #it doesnt help that he loves using his claws to gain purchase in your foot too lol #gutsys cats

[writer-in-a-basement]

This isn't anything writing related or even related to shit I'm into but you just gotta love googling something about a weird pain, getting "cancer" (because of course), then googling the same thing with the chronic condition you suspect you have and immediately getting "Oh yeah, this is totally related"

#gotta love chronic illnesses #hypermobilty syndrome #chronic pain #a weird pain in my kidneys COULD be cancer but it COULD also just be something wrong with my internal tissue again #it's probably not going to kill me

[lesbians4lino]

nothing will ever top the satisfaction of going back to the pediatrician that told me i just needed to drink more water a year later with the results of a blood test showing mctd

#girl was STRESSED it was so funny #in the haha funny kidney failure teenage arthritis way unfortunately #mixed connective tissue disorder #mctd

[greenwire]

the first area of colonization of a baby is the skin when it passes through the vaginal canal, its why vaginal flora is important! But otherwise agree about mouths being gross and breastmilk should be for babies only not horny men

my training in human infectious disease and microbiology is way out of date, but you're right. also whether your were born vaginally vs born via c section has an impact on your dental health even as an adult.

#I took those courses before the ''microbiome'' was a commonly discussed phenomenon #not a physician just have some medical research background #i remember one case from those days where a man's finger was bitten and he nearly died. lost his finger. #not even the grossest thing i've ever seen #the grossest thing i ever saw was the woman whose kidney was rejected and she had to have surrounding tissue taken out too #it was a LARGE wound. they had it under vacuum.

[flamminnt]

Donate to Help

I am reaching out to you all today to ask for your support in a difficult time. After suffering a stroke, I have been struggling with medical complications and personal hardships. My family and I were forced to leave our home, leaving behind all our belongings. We are currently in need of funds for medication, medical equipment, home furnishings, and a vehicle. Any amount you can donate will be greatly appreciated and will go a long way in helping us rebuild our lives. Please consider donating and sharing this campaign with others. Thank you for your support. https://gofund.me/4ea797d8

#please donate #recovery #stroke recovery #kidney disease #mixed connective tissue disease #epilepsy #disability #money #medication

[transplants-india]

Honoring Heroes: Odisha CM Recognizes Organ Donors with State Honors

Organ donation is a massive problem in India. There are hundreds of thousands of people who need organ transplants in Mumbai to stay alive. But there are way more people who need transplants than there are organ donors. So many people are stuck waiting, hoping an organ becomes available in time. The biggest need is for kidney transplants - that's what most people are waiting for an organ donor.

Overcoming Barriers: Education and Financial Support There are a few reasons why there aren't enough organ donors in India. Many people don't understand its importance or have misconceptions about it because of cultural/religious beliefs. The cost of transplant surgeries is also really expensive for many families. Some organizations are already working on this. A transplant organization in India provides money, counseling, and other support to transplant patients and their families. The MOHAN Foundation is a non-profit organization that spreads awareness about organ donation and helps set up transplants across India.

Odisha's Pioneering Initiative In the middle of all this, the state of Odisha in India has done something remarkable to honor organ donors. The Chief Minister there, Naveen Patnaik, made it so that organ donors get treated with special honors - like really important or famous people. This includes things like a 21-gun salute, having their body wrapped in the Indian flag and other ceremonies. The families of organ donors also get financial help for kidney transplants in India and are recognized yearly on World Organ Donation Day. It's a big way to show how much organ donation is appreciated.

A Powerful Message and Ripple Effect Odisha's new policy for honoring organ donors is a compelling statement. It says that organ and tissue transplantation in India is an incredibly heroic and respectable thing to do. By giving donors the same types of honors as famous or important people, the government recognizes their selfless sacrifice and how their decision saved lives. This doesn't just honor the donors and their families. It could also inspire more people to become donors themselves. If it motivates others, it could lead to a lot more organ funding for liver transplants in India over time.

Transplant Facilities in Mumbai There are some good places to go for people in Mumbai who need information about organ transplants or are considering becoming organ donors. The Lilavati Hospital & Research Centre has programs for liver and kidney transplants. Global Hospitals Parel can do transplants for different organs, too. There's also an organization called Jeevan Aarogya that is run by the Maharashtra State Government. Their goal is to educate people about organ donation in Mumbai and get more donors signed up. They do a lot to spread awareness about this important cause.

A Step Towards a Brighter Future Odisha's giving state honors to organ donors is a huge deal that could really increase organ donation across India. By honoring the amazing sacrifices donors make and supporting their families, the government is helping create a future where more lives are saved through organ donation. With the massive shortage of organs in India, this pioneering approach from Odisha gives people hope.

#transplant organization #organ donation #organ transplant #kidney transplant #organ transplantation #funding for liver transplant in india #funding for kidney transplant #organ and tissue transplant in India

[the-acid-pear]

Adoring the human centipede 3 as much as I do is so embarrassing to me because unlike the first movie this one is so stupid so silly like the first one I genuinely think is a misunderstood masterpiece and I've given an indepth analysis of why it works but 3 is just sooo funny and Dieter Laser does such a good fucking job like it's such a stupid movie and yet it's one of my all time favorites 😭😭😭

#luly talks #please watch it 👍 #for the sake of old men being fucked on their soft kidney tissue while being called daddy 👍👍👍 #also cute short fat guys sucking cock i always forget to bring that up #i mean it gets kinda overshadowed but it adds so much to the scene and to bill's character #GOD i fucking need that bald fucker so BAD y'all dont even get it #they're gonna put me in a straightjacket he makes me mentally ill start chewing wood it is so UGH #HE DONT HAVE ANY HAIR TO PULL SO IMMA JUST SLAP THE BACK OF HIS HEAD 😁😁😁😁😁

[littleforestsims]

Obligatory "I'm still alive" post. In short, I've been struggling a lot with constant pain and its not helping my health, and alongside that work has just being nonstop. It's been sapping most of my energy, but hopefully with new meds I can get it under control again and find the energy to do more ✨️ s t u f f ✨️.

But.... some good news~ I'm working on a save file! There'll be no CC, but I am using content from multiple packs. It's going to take me a while, but I'm starting with Willow Creek first. I'm renovating lots, replacing some, and plan for it to be a 'five years later' kind of thing, but there will be some 'non-canon' stuff, so think of it as an alternative universe in some places. Some townies will be new, some will have aged up, moved to other worlds (where they'll be added when I get to that world), etc.

When I get to between 50% and 75% completion, I'm going to start sharing some pics. I'll then release it one world at a time~ :3

Hope you're all having a spooky October! ♡

#sims 4 #sims 4 world #update #blep~ I had a kidney removed 3 and a half years ago and have nerve damage #but its gotten really bad recently and all scans/bloods are normal so they think scar tissue is trapping some nerves #but it hurts so freakin much some days ajdhjsjjd #so that's why my energy has been non existent shjdjd

[vhstown]

please stop scrolling and take the time to read this.

i don't think people understand the extent of the horror happening in palestine right now. "death" means nothing to people because of desensitisation so let me just tell you what white phosphorus is. it's being used in israeli munitions and has been and will continue to be fired across gaza and the palestinian borders.

white phosphorus burns when it comes into contact with oxygen (at nearly 800°C or 1500°F. the human body can withstand ~50°C for reference.) the air you breathe in ignites and it is near impossible extinguish. it sticks to clothing and skin and is very difficult to remove because it will continue to ignite in air. it burns flesh up to the bone and even past the bone because it penetrates tissue and is absorbed VERY easily. if you inhale it it'll destroy your respiratory tract and lungs. it can cause failure in multiple organs including the liver, kidneys and heart. it is being released in one of the most densely populated places on earth.

the only way to treat someone exposed to white phosphorus is to submerge them in saline or water and to pick out the substance with forceps, and when you undress a wound the substance can re-ignite. this is just ONE weapon that is being used to kill palestinian people right now. palestine does not have access to medical care, humanitarian aid, power, or internet. their hospitals are being bombed. gaza is one of the most densely populated places in the world with over 50% of the population being children. many children are the sole survivors of their families. there are videos of children experiencing panic attacks and symptoms of ptsd. the fact that israel has committed war crimes in plain sight means that we can only imagine what will happen to the palestinians in complete darkness.

israel has and will continue to deny this. your interests and fandom will still be here, you will wake up tomorrow morning and see your friends and family, but an entire nation of people are being wiped off the map. being silent is being complacent. reblog, spread information, tell people in real life, attend protests, sign petitions, call your government offices, at the very least be angry and upset and horrified because once you become numb and indifferent and hopeless the oppressors will have already won.

what's happening right now is more than a genocide and once it becomes a part of history we'll wonder how the world let this happen. genocides have been part of all nations. just because it is far away does not mean you don't have to be concerned. the fact that YOUR governments and YOUR idols and the people around YOU are supporting the mass eradication of an entire group of people should scare you. it shouldn't make you feel anything less than sick and angry and disgusted. DO something about it, no matter how small you feel your voice is, because palestinians no longer have one.

[edit] links to some helpful reblogs: one & two

post on how you can help palestine

learn about palestine with this masterlist of info

+ a further reblog of mine

[edit 2] about palestinians "not having a voice" at the time i wrote this post internet connection was cut off entirely and even journalists weren't able to report for a period of time — that is all i meant by that. they of course have a voice and i never meant to undermine how people are risking their lives in gaza to get information out there and i apologise if thats what people took from it, it was not my intention but it is entirely my bad. please continue to spread information and updates from gaza as they come.

#please reblog with any useful resources you may have #or just in general #i dont care that this is a fanfiction blog because nobodys bloody made-up characters are important right now #look through tags and reblog the newer things because theyre being supressed #no matter how many followers you have #israel palestine conflict #free gaza #palestine #gaza #gaza strip

[llycaons]

when they take out a liver they clutch it to their abdomens and cradle it like a baby. its glorious ngl

#kidneys not so much. they're covered in fat so it's just a yellow tissue-covered mass they take to the back #cor.txt

[kaijutegu]

So. Now that she's home and safe and gonna be ok, I can talk about this.

I almost lost Kaiju. Christmas Day. I was woken up by a phone call from Allison, who will be referred to a LOT in this story. Allison runs the pet store where I board Kaiju. She called to tell me that Kaiju had lost a LOT of blood. (As it turns out, half her blood volume. Humans die when we lose 40%, just so you know. She lost 50%.)

There were no visible injuries, and she had passed a bloody stool. Or rather, a blood clot with some poop in it. She continued to pass only blood when they put her in the bathtub to clean her up. If I'd taken her anywhere else, that... would have been it, probably.

But Allison is an actual miracle worker and knew an emergency vet who was open- on Christmas Day- and could see reptiles. As soon as she called me, she took her to the e vet, where they gave her fluids and oxygen and got her stable. They did some x rays and found... nothing.

In fact, the e vet actually complimented me on her bone density and how nice her toe joints look. Whatever this mysterious haemorrhage was, it was in the soft tissue.

The immediate thoughts were:

Impaction

Cancer invading an artery

Aneurism

Reproductive issues

However, the emergency vet couldn't figure it out, and my vet was out of the country. The e vet consulted with a lot of vets and it was decided she'd go into Chicago Exotics for care the next day- they were willing to see her on immediate notice. Allison drove her over and they did an ultrasound... and couldn't differentiate the mass they found.

So, exploratory surgery it was.

But... she didn't have enough blood for that. She wouldn't have survived... if Allison hadn't found blood for her. Tegu donors were found, the transfusion happened, and was completely successful.

And what the surgery found was completely unexpected. No cancer. No repro issues. No typical impaction.

Instead? Weird white things in her muscles and a partial impaction that seems to be related to a reduction in her ability to properly digest. There are two possible diagnoses at this point. One is visceral gout. This is very strange because in reptiles, articular gout basically always happens first, and her kidneys are fine.

The other option? Weird, potentially cross species parasite she picked up when she was in the Everglades. Something she's likely had all her life, something that was dormant until recently.

I'll know when the pathology report comes back in a week or so.

Anyways! She is doing very well. She is alert and interested in things. She has an incredible appetite, even though she can't have solid food yet. She's on three meds, including one I have to inject. At her three week recheck, we will add a fourth- either the correct anti-parasitic or a medication to improve kidney function, depending on the diagnosis. Currently she's in a hospital cage and she hates it- she can't have any substrate because of the stitches.

The vet says it should take about three months until she makes her full blood volume. Her pack cell count should be at 35%. It was at 7% on the 26th. But by the 28th, it was at 10%. She's gonna be ok. She's tough. My little girl is a fighter, always has been. You have to be scrappy to survive in the wild.

And throughout this entire experience, everybody has told me how lovely her personality is. Through the injections and cloacal probing and everything, she never bit or even tried to. The vet didn't think she even wanted to bite. Like it wasn't a question of wanting to bite and not being strong enough- it's just not something in her behavioural repertoire. She doesn't bite because she doesn't want to. Because even at her most scared, at her most painful, she's still Kaiju, the best tegu to ever live. Love is stored in the tegu, and it continues to be stored in the tegu. We have a long road ahead of us, but she's out of the woods and is going to be ok. We both are.

Also, consider this a MAJOR plug for Curious Creatures in Chicago. I'm never going to board my animals anywhere else.

#reptile #lizard #tegu #kaiju #reptiblr

[sybilsherbal]

Choline promotes health of liver, kidney & nervous tissue

#choline #supplements #liver #kidney #nervous-tissue #tissue

[togglesbloggle]

Voltaire's Prayer

“I have never made but one prayer to God, a very short one: Oh Lord, make my enemies ridiculous. And God granted it." -Volaire’s letter to Étienne Noël Damilaville, 16 May 1767

I’m inordinately fond of sex, in the political sense.  It’s saved us so often from the worst parts of ourselves.

As far as anti-authoritarian elements of the human experience go, sex is right up there with curiosity and the search for truth- maybe even more so.  When a new tyrant comes to town, shutting down the universities and the libraries is only the second thing they try.  The first thing is to regulate human sexuality to within an inch of its life.  Rules for marriage, rules for courtship, rules for which genitals may touch and where they may touch and when they may touch.  Rules for who and rules for whom.  Rules for which kinds of sex must doom characters in literature, rules for which things may be described as sexy, rules for which things may be described in a sexy way.

Of course they do!  If you’re trying to bind a large polity together under a common ideological narrative, to render people predictable enough to quash dissent and legible enough to exert power through them, the last thing you need is a bunch of folks running around being horny about stuff without permission.  Nature gifted us with a great capacity for reason and community; we have the innate opportunity to learn about ourselves and our neighbors, and to form complex societies based on that understanding.  It was Aristotle who first called us the political animal, and the fruits of that extraordinary capacity will always be within our reach, if only we can come together within a shared understanding.  The invention of the city is the great triumph of our species, and with it we conquer the universe.

But also this extraordinary, reasoning mind has been sculpted from the raw clay of a biology that’s anchored in sexual reproduction, and this ends up being very, very funny.

The problem isn’t so much that the sex instinct exists, per se.  It’s how it’s implemented.  Like most biological forms, the full complement of 86 billion(!) neurons in your brain aren’t encoded in a particular configuration; the brain is much too complex to be described so precisely in the only ~725 megabytes or so of human DNA.  The particular shape of your brain is in there somewhere- the lobes and subregions responsible for vision, memory, cognition, all that- but only up to a point.  The genius and fundamental limitation of genetics is that, below a certain level, the genes instead describe a process for the production and reproduction of specialized cells, and simply constructs them in such a way that they can be relied upon to order themselves as they go.

This is all well and good when we’re talking about kidneys and livers, but the fact that you can encode any kind of specific behavioral instinct in a brain this way is nothing short of a minor miracle.  Think about it!  Spiders don’t have a ‘spider web’ gene, the gene is for ‘proteins that come together in self-assembling electrochemically sensitive gelatin tissue which, when complete, encodes patterns that operate organ systems such as legs and spinnerets in such a way as to reliably create silk webs.’  This is absurdly impressive, and also completely insane.

What I’m getting at is, powerful behavioral instincts in a complex animal aren’t precise instruction manuals by which we pursue evolutionarily advantageous behaviors.  Sex and eros are prior to logic or language, let alone strategy.  Sex is a double-thick electrical wire discharging lightning bolts right through the middle of our cognitive centers, installed in the brain by a surgeon wearing mittens.  It’s an untethered firehose whipping chaotically through the cathedral, unpredictably spraying golden reliquaries with substances unmentionable.  It’s the first and greatest anarchist.

I really can’t overstate my gratitude for this.

Obviously this results in any number of deeply goofy outcomes by way of kinks and odd sexual practices- it gets tangled with pain centers, with random bits of anatomy and proprioception, with our taboos and aversions, with our greatest terrors or our greatest yearnings or just arbitrary stimuli from adolescence, and of course it gets enmeshed so often with our notions of power and submission.  It imbues these things with a fascination and potency out of all proportion with their mundane meanings.  And ultimately, you end up with human pleasures and human values that diverge so far from banal evolutionary imperatives as to be all but unrecognizable.

Even when this process somehow manages to propagate through the brain in such a way as to drive behaviors that are legibly aligned towards some adaptive constraint- e.g. heterosexual mating practices resulting in biological reproduction and careful childrearing- it’s still madness.  Love and sex penetrate deeply across tribal and national and racial boundaries, across economic interests, across battle-lines and enmities.  We become traitors, apostates, emigrants, and artists.  Declare a law, and in short order some hot-headed young people come along to break it in the name of sexual passions you could not possibly have seen coming.  Divide your neighborhood into us and them, and by the time the ink is dry on your proclamation there will be a forbidden relationship across the fence.  There is no social order, no ethical system, no theory of human nature that can entirely withstand contact with the full spectrum of human sexuality, because sex and eros are always going to be exactly as bonkers as the complexity of the human mind and culture will allow, plus a little extra just to be sure.

This isn’t always a delight, of course.  Many prohibitions exist for a very good reason, and the chaos of human sexuality makes no exemptions for true evil.  Some of us end up really, truly victims of this process.  But for all the dangers, the chaos at the root of all this isn’t oriented towards evil.  Chaos just means chaos, essentially arbitrary and hence absurd in character.

And in the grand analysis, we are so lucky to have this thing moving through our communities, this ridiculous madness that guarantees that there will be cracks in every wall and slips exploding cigars in the pockets of the powerful few.  Not in everybody as individuals, of course, and not everybody the same amount; asexuality is certainly one of the outcomes that all this mad gallivanting through our brains can produce.  Sexuality would never be so predictable as to guarantee its own existence, after all.  That’s part of what makes the joke so funny.

But all of us, regardless of sexuality, get to live in a world where the grand anarchy of sex is constantly driving home this lesson that no category is inviolate and no law is perfect.  That we should not and cannot take ourselves too seriously, or forget that we’re animals.  That we don’t exist only for the sake of others, or within their understanding.  That cities are made of cooperation, grace, and forbearance- not conformity or mere compliance.

People sometimes worry about immortality.  In the political sense, I mean.  They worry about eternal dictatorships and unconquerable gerontocracies.  This fear isn’t entirely unjustified; death has often played a role in progress and liberation.  But as long as enough of us are still getting horny without permission, still falling in love in stupid ways, I think we’ll be okay.  Romeo and Juliet don’t have to die at the end to make a difference in the world, as long as they’re brave enough to get weird with it.

[dekarios]

i need help with vet bills.

this is a remake of my original post which you can find here.

this is toos, she's a 10 year old miniature schnauzer who was recently diagnosed with stage 4 kidney failure. she is currently on medication to keep her stable, and she's steadly improving and getting better, but over the course of figuring out what's wrong with her, we accumulated thousands of pounds of vet bills, as well as now needing to keep up with her medication, which is not cheap. there's also hope that when she is more stable, she can undergo surgery to have ovarian tissue discovered over the course of her vet treatments removed, which will be costly.

i've emptied my savings trying to pay for this, and my parents have been taking from their pensions, but we are quickly running out of options for where to get more money. we're desperate.

please consider donating to my paypal, every little helps. thank you!

#fray.txt #please boost ^_^