Thinking about Miranda's line that she's not the first one her father made, just the first one that he kept.
Thinking about how she describes herself as having been tailor-made: looks, biotics, the whole deal.
Thinking about her age and how humans were just barely learning about biotics when her father began his tinkering.
Thinking about how biotics requires in-utero exposure to eezo and how many of those infants developed cancer and birth defects instead of biotics. Thinking about how few actually developed usable biotic potential.
Thinking about how many older sisters Miranda never even knew about.