In primary patient samples and in multiple mouse models: at rest/sleep, breast turmours shed more CTCs and these rest-time CTCs are more aggressive
(Image above: mouse model where circadian rhythm is impaired -> no CTCs!!! If you get breast cancer don't sleep / catnaps only lol)
Did scRNAseq on the CTCs: rest-time CTCs have high expression of cell division genes; active-time CTCs express high translation/ribosome biogenesis genes. (This is true of the primary tumours as well)
Not due to circadian clock gene expression (circadian clock is defunct in cancer cells)
Not due to interstitial fluid pressure
Is due to response to circadian rhythm hormones (receptors for these are upregulated) - glucocorticoid receptor, androgen receptor, and insulin receptor
Me realizing I can't get away from existential horror themed circus shows/childcore themed fandoms (examples are Sunnyday Jack, my own Caretime Clowns, my own fnaf series, Welcome Home, The Amazing Digital Circus) along with making characters based on those premises.
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Me accepting that shit as fact and will defend it
I'm currently struggling with a TADC oc I'm making, I got her drawn....I just don't know what to do with her lalaloopsy Betty spaghetty hair
"When you forget to give your homie a blanket at the sleepover" ^
Starting off strong with my new oc's, I give you Jace Calloway the human, and Alejandro D. Fae the... Fae. Two chaotic roomates, getting into trouble in both worlds alikes. Jace is charming, guitarist/bard and programmer (his main job that he hates), and Al is a chiiiiill asf fairy.
This is an accidental but blessed collab between @jellazticious. A JOLLY GOOD fellow is he, go look at his stuff, its great.
I am slowly gonna start showing more stuff of these guys and other characters too. It's a very lighthearted, slice of life fantasy comedy and it's been such fun to write and make characters for OUGH.
Also the name of it in the tags is "Cursed to Charm"