When Alopex and Raph become friends, Alopex begins trying to teach Raph how to balance out his family life with his independent life. This starts with accepting Mikey's requests to stop Raph's coddling.
After this interaction, Mikey learns it was Alopex's fault and so begins a one-sided rivalry between Mikey and Alopex (He says that she's trying to steal Raph, Leo and Donnie are just watching it all go down)