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Pyruvate dehydrogenase is inactive in the phosphorylated state, and the regulatory protein kinase is inhibited by pyruvate, allowing the enzyme to be active when substrate is available (Figure 12.12).
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
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The Nash Logs #2
(A large Timeskip of events that will come later. This is relevant after Nash's Death.)
A king has to be strong. He has to be willing to sacrifice himself for his people. That was something Nash couldn't understand. Why had his party brought him back at the cost of one of their own lives?
The horror on the faces of his people was understandable after he was told what had happened, he wished he'd handled it more gracefully, but with the whole crisis? He just had been so scared for his party. Though, his death isn't what bothered him. Nor was it really pain over Nylia's sacrifice. It was more that the reality of what he was had finally sunk in.
His parents had always warned him away from certain temples and taverns, and he'd felt the strange burning sensation after using certain spells before. His species just wasn't meant to exist solely in the mortal realm, unfortunately. He knew that, though. His main issues were with his new problems.
He felt physically sick within a certain radius of their Church for Hera. Before he'd only tingled, but now he worried he'd collapse if he stepped one hoof onto the holy soil. The same occurred if the Paladins orCleric came too close. He was skiddish, their energy making him flinch. Countless spells were also vividly deadly to him now. Particularly, the ones that crumpled hoards of reminded creatures in their wake. Nash constantly worried about being caught at the receiving end of one of those. Locations and Spells were worrying, but his physical qualities also gave him too much heartache. His blood had stopped flowing. Upon receiving a scratch during training, he learned that his blood is curdled and pitch black. A nasty sludge. His Blood Curse still functions as normal, but Nash finds the sight of the substance a gruesome reminder. He was cold to the touch as well. He guessed he never noticed, he'd always had cold hands and he stayed around fire enough that it was a blessing in the past. Now though? His siblings flinch when he gives them hugs, as though he were a sculpture of ice. He only learned this fact when he'd shaken hands with Gray after a well-won game of darts. (Gray was a Rogue, so of course he'd won easily.) They'd had a few brews, and Gray had said Nash felt cold as a corpse. They'd laughed it off, but Nash remembered. It bothered him to know.
His least favorite part of this new shape is something that Maldric informed him of, a few weeks after Nash returned. Nash had remarked on how he could feel Maldric's heartbeat when they hugged, and how he loved it. Maldric had been quite. Later on, he'd leaned against Nadh for a few minutes, and whispered softly that he couldn't feel Nash's heartbeat anymore. And Maldric was right. Nash's heart, the place over which his Tattoo centered, the part of him filled with so much love and compassion... had run cold. Nash should've known better, but he didn't ever stop to think. He never did.
It's not uncommon for Nash to be alone and press his hand to his chest, holding his breath, hoping that someday it would start beating again. It never will. He realized, after some thinking, and some talking with his Advisor, that his body will fall into such disrepair that he'll be of no use to his party or people. Unfit to rule or be seen. He'll rot away, and his soul will be guided away once again. That is, if he doesn't corrupt into an unthinking undead first. He hopes that his party would give him the mercy of a private execution, and they'd return him to his crypt, or burn him on the pyre like a proper warrior.
He's not a proper warrior though. He knows that. He's some ungodly creature, given a second chance out of loyalty and sentiment. Gods forbid, he loves his party dearly, but in the dark of the night, sometimes he wishes they'd saved themselves the pain of having to watch him die twice over.
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The first steps in the synthesis of sulfur-containing organic compounds involve the reduction of sulfate and synthesis of the amino acid cysteine (Figure 13.15). (...) Activation begins with the reaction between sulfate and ATP to form adenosine-5'-phosphosulfate (APS) and pyrophosphate (PPi) (see Figure 13.15):
SO4²- + ATP → APS + PPi
Glutathione, ferredoxin, NAD(P)H, or O-acetylserine may serve as electron donors at various steps of the pathway (see Figure 13.15).
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
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embryonic development rate varies among species & is correlated w lifespan, body size, life history etc
human embryonic development is 2-3 times slower than mouse
this this paper: in vitro model of developmental rate in hESC and mESC cells
hESC cells differentiate slower (and divide slower)
mass-specific CCM metabolic ratesin hESC cells are slower than mESC cells
this is because human cells are larger and contain more stuff lol
inhibit ETC slows development rate: not related to ATP production but related to NAD+/NADH ratios
increased NAD+ leads to faster embryonic development by driving faster protein translation rates
Nature Jan 2023, PMID: 36599986
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Rotenone-insensitive NAD(P)H dehydrogenases, mostly Ca²+-dependent, are also attached to the outer surface of the inner membrane facing the intermembrane space.
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
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🔬🌀Demystifying the Krebs Cycle: A Deep Dive into Cellular Respiration! 🌀🔬
Prepare for a thrilling journey into the heart of cellular metabolism! 🌟✨ Today, we unravel the intricacies of the Krebs Cycle, also known as the Citric Acid Cycle or Tricarboxylic Acid Cycle, a cornerstone of energy production in our cells. 💡🤯
The Krebs Cycle: Named after its discoverer, Sir Hans Krebs, this metabolic pathway occurs within the mitochondria and is a central hub in cellular respiration.
🔍Step 1: Acetyl-CoA Entry
Acetyl-CoA, derived from the breakdown of glucose or fatty acids, enters the cycle.
It combines with oxaloacetate to form citrate, a six-carbon compound.
🔍Step 2: Isocitrate Formation
A rearrangement converts citrate into isocitrate.
The enzyme aconitase facilitates this transformation.
🔍Step 3: Alpha-Ketoglutarate Production
Isocitrate undergoes oxidative decarboxylation, shedding a CO2 molecule and yielding alpha-ketoglutarate.
NAD+ is reduced to NADH in this step.
🔍Step 4: Succinyl-CoA Synthesis
Alpha-ketoglutarate loses CO2 and acquires a CoA group to form succinyl-CoA.
Another NAD+ is reduced to NADH.
This step is catalyzed by alpha-ketoglutarate dehydrogenase.
🔍Step 5: Succinate Formation
Succinyl-CoA releases CoA, becoming succinate.
A molecule of GTP (guanosine triphosphate) is generated as a high-energy phosphate bond.
Succinate dehydrogenase is pivotal, transferring electrons to the electron transport chain (ETC).
🔍Step 6: Fumarate Generation
Succinate is oxidized to fumarate with the help of the enzyme succinate dehydrogenase.
FADH2 (flavin adenine dinucleotide) is formed and transfers electrons to the ETC.
🔍Step 7: Malate Formation
Fumarate undergoes hydration to form malate, catalyzed by fumarase.
🔍Step 8: Regeneration of Oxaloacetate
Malate is oxidized back to oxaloacetate.
NAD+ is reduced to NADH.
Oxaloacetate is ready to initiate another round of the Krebs Cycle.
The Krebs Cycle - an intricate dance of chemical transformations fueling the cellular machinery of life. 🕺💃 Dive deeper into cellular respiration, where molecules tango to generate ATP, our cellular energy currency!
📚References for In-Depth Exploration📚
Berg, J. M., Tymoczko, J. L., & Stryer, L. (2002). Biochemistry (5th ed.). W. H. Freeman. Chapter 17.
Voet, D., Voet, J. G., & Pratt, C. W. (2008). Fundamentals of Biochemistry (3rd ed.). John Wiley & Sons. Chapter 17.
Lehninger, A. L., Nelson, D. L., & Cox, M. M. (2008). Lehninger Principles of Biochemistry (5th ed.). W. H. Freeman. Chapter 17.
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