Story from the Washington Post here, non-paywall version here.
Washington Post stop blocking linksharing and shit challenge.
"The young woman was catatonic, stuck at the nurses’ station — unmoving, unblinking and unknowing of where or who she was.
Her name was April Burrell.
Before she became a patient, April had been an outgoing, straight-A student majoring in accounting at the University of Maryland Eastern Shore. But after a traumatic event when she was 21, April suddenly developed psychosis and became lost in a constant state of visual and auditory hallucinations. The former high school valedictorian could no longer communicate, bathe or take care of herself.
April was diagnosed with a severe form of schizophrenia, an often devastating mental illness that affects approximately 1 percent of the global population and can drastically impair how patients behave and perceive reality.
“She was the first person I ever saw as a patient,” said Sander Markx, director of precision psychiatry at Columbia University, who was still a medical student in 2000 when he first encountered April. “She is, to this day, the sickest patient I’ve ever seen.” ...
It would be nearly two decades before their paths crossed again. But in 2018, another chance encounter led to several medical discoveries...
Markx and his colleagues discovered that although April’s illness was clinically indistinguishable from schizophrenia, she also had lupus, an underlying and treatable autoimmune condition that was attacking her brain.
After months of targeted treatments [for lupus] — and more than two decades trapped in her mind — April woke up.
The awakening of April — and the successful treatment of other people with similar conditions — now stand to transform care for some of psychiatry’s sickest patients, many of whom are languishing in mental institutions.
Researchers working with the New York state mental health-care system have identified about 200 patients with autoimmune diseases, some institutionalized for years, who may be helped by the discovery.
And scientists around the world, including Germany and Britain, are conducting similar research, finding that underlying autoimmune and inflammatory processes may be more common in patients with a variety of psychiatric syndromes than previously believed.
Although the current research probably will help only a small subset of patients, the impact of the work is already beginning to reshape the practice of psychiatry and the way many cases of mental illness are diagnosed and treated.
“These are the forgotten souls,” said Markx. “We’re not just improving the lives of these people, but we’re bringing them back from a place that I didn’t think they could come back from.” ...
Waking up after two decades
The medical team set to work counteracting April’s rampaging immune system and started April on an intensive immunotherapy treatment for neuropsychiatric lupus...
The regimen is grueling, requiring a month-long break between each of the six rounds to allow the immune system to recover. But April started showing signs of improvement almost immediately...
A joyful reunion
“I’ve always wanted my sister to get back to who she was,” Guy Burrell said.
In 2020, April was deemed mentally competent to discharge herself from the psychiatric hospital where she had lived for nearly two decades, and she moved to a rehabilitation center...
Because of visiting restrictions related to covid, the family’s face-to-face reunion with April was delayed until last year. April’s brother, sister-in-law and their kids were finally able to visit her at a rehabilitation center, and the occasion was tearful and joyous.
“When she came in there, you would’ve thought she was a brand-new person,” Guy Burrell said. “She knew all of us, remembered different stuff from back when she was a child.” ...
The family felt as if they’d witnessed a miracle.
“She was hugging me, she was holding my hand,” Guy Burrell said. “You might as well have thrown a parade because we were so happy, because we hadn’t seen her like that in, like, forever.”
“It was like she came home,” Markx said. “We never thought that was possible.”
...After April’s unexpected recovery, the medical team put out an alert to the hospital system to identify any patients with antibody markers for autoimmune disease. A few months later, Anca Askanase, a rheumatologist and director of the Columbia Lupus Center,who had been on April’s treatment team, approached Markx. “I think we found our girl,” she said.
Bringing back Devine
When Devine Cruz was 9, she began to hear voices. At first, the voices fought with one another. But as she grew older, the voices would talk about her, [and over the years, things got worse].
For more than a decade, the young woman moved in and out of hospitals for treatment. Her symptoms included visual and auditory hallucinations, as well as delusions that prevented her from living a normal life.
Devine was eventually diagnosed with schizoaffective disorder, which can result in symptoms of both schizophrenia and bipolar disorder. She also was diagnosed with intellectual disability.
She was on a laundry list of drugs — two antipsychotic medications, lithium, clonazepam, Ativan and benztropine — that came with a litany of side effects but didn’t resolve all her symptoms...
She also had lupus, which she had been diagnosed with when she was about 14, although doctors had never made a connection between the disease and her mental health...
Last August, the medical team prescribed monthly immunosuppressive infusions of corticosteroids and chemotherapy drugs, a regime similar to what April had been given a few years prior. By October, there were already dramatic signs of improvement.
“She was like ‘Yeah, I gotta go,’” Markx said. “‘Like, I’ve been missing out.’”
After several treatments, Devine began developing awareness that the voices in her head were different from real voices, a sign that she was reconnecting with reality. She finished her sixth and final round of infusions in January.
In March, she was well enough to meet with a reporter. “I feel like I’m already better,” Devine said during a conversation in Markx’s office at the New York State Psychiatric Institute, where she was treated. “I feel myself being a person that I was supposed to be my whole entire life.” ...
Her recovery is remarkable for several reasons, her doctors said. The voices and visions have stopped. And she no longer meets the diagnostic criteria for either schizoaffective disorder or intellectual disability, Markx said...
Today, Devine lives with her mother and is leading a more active and engaged life. She helps her mother cook, goes to the grocery store and navigates public transportation to keep her appointments. She is even babysitting her siblings’ young children — listening to music, taking them to the park or watching “Frozen 2” — responsibilities her family never would have entrusted her with before her recovery.
Expanding the search for more patients
While it is likely that only a subset of people diagnosed with schizophrenia and psychotic disorders have an underlying autoimmune condition, Markx and other doctors believe there are probably many more patients whose psychiatric conditions are caused or exacerbated by autoimmune issues...
The cases of April and Devine also helped inspire the development of the SNF Center for Precision Psychiatry and Mental Health at Columbia, which was named for the Stavros Niarchos Foundation, which awarded it a $75 million grant in April. The goal of the center is to develop new treatments based on specific genetic and autoimmune causes of psychiatric illness, said Joseph Gogos, co-director of the SNF Center.
Markx said he has begun care and treatment on about 40 patients since the SNF Center opened. The SNF Center is working with the New York State Office of Mental Health, which oversees one of the largest public mental health systems in America, to conduct whole genome sequencing and autoimmunity screening on inpatients at long-term facilities.
For “the most disabled, the sickest of the sick, even if we can help just a small fraction of them, by doing these detailed analyses, that’s worth something,” said Thomas Smith, chief medical officer for the New York State Office of Mental Health. “You’re helping save someone’s life, get them out of the hospital, have them live in the community, go home.”
Discussions are underway to extend the search to the 20,000 outpatients in the New York state system as well. Serious psychiatric disorders, like schizophrenia, are more likely to be undertreated in underprivileged groups. And autoimmune disorders like lupus disproportionately affect women and people of color with more severity.
Changing psychiatric care
How many people ultimately will be helped by the research remains a subject of debate in the scientific community. But the research has spurred excitement about the potential to better understand what is going on in the brain during serious mental illness...
Emerging research has implicated inflammation and immunological dysfunction as potential players in a variety of neuropsychiatric conditions, including schizophrenia, depression and autism.
“It opens new treatment possibilities to patients that used to be treated very differently,” said Ludger Tebartz van Elst, a professor of psychiatry and psychotherapy at University Medical Clinic Freiburg in Germany.
In one study, published last year in Molecular Psychiatry, Tebartz van Elst and his colleagues identified 91 psychiatric patients with suspected autoimmune diseases, and reported that immunotherapies benefited the majority of them.
Belinda Lennox, head of the psychiatry department at the University of Oxford, is enrolling patients in clinical trials to test the effectiveness of immunotherapy for autoimmune psychosis patients.
As a result of the research, screenings for immunological markers in psychotic patients are already routine in Germany, where psychiatrists regularly collect samples from cerebrospinal fluid.
Markx is also doing similar screening with his patients. He believes highly sensitive and inexpensive blood tests to detect different antibodies should become part of the standard screening protocol for psychosis.
Also on the horizon: more targeted immunotherapy rather than current “sledgehammer approaches” that suppress the immune system on a broad level, said George Yancopoulos, the co-founder and president of the pharmaceutical company Regeneron.
“I think we’re at the dawn of a new era. This is just the beginning,” said Yancopoulos."
-via The Washington Post, June 1, 2023
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Propaganda
Peter Falk (The Great Race, Robin and the 7 Hoods)—let me just quote Frank Capra: "the entire production was agony ... except for Peter Falk. He was my joy, my anchor to reality. Introducing that remarkable talent to the techniques of comedy made me forget pains, tired blood, and maniacal hankerings to murder Glenn Ford (the film's star)." i also just find scrungly little guys to be the peak of attraction.
Conrad Veidt (The Cabinet of Dr. Caligari, The Man Who Laughs)—the ultimate goth boy! as well as classics like the cabinet of dr caligari, the man who laughs (which his character in was the visual inspiration for the joker) and casablanca, he starred in the german polemic melodrama different from the others in 1919 in one of the first sympathetic portrayals of gay characters in cinema, co-written by the gay researcher & activist magnus hirschfeld much of whose pioneering research on human sexual diversity was destroyed by the nazis
This is round 3 of the bracket. All other polls in this bracket can be found here. Please reblog with further support of your beloved hot sexy vintage man.
[additional propaganda submitted under the cut]
[editor's note: I received such an enormous volume of propaganda for Veidt I could only include some of it here—and unfortunately Tumblr isn't letting me repost any gifs at all, which I didn't expect! Please don't be offended if something you sent in didn't make the cut.]
"Just look at him your honor. Ich würde"
Submitted: Tumblr thread on Veidt
Submitted: Tumblr post on Veidt
Peter Falk propaganda:
"listen Peter Falk saved the day for me in robin in the 7 hoods. he saved me in it's a mad mad mad mad world. he damn right resuscitated me in the great race. every movie this man is in is made better by his presence and he should eat the competition alive."
Submitted: "1:56:30 on for Peter Falk's ass in It's a Mad, Mad, Mad, Mad World. yes he falls off a building yes he drives a cab yes he hates the cops"
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Family Feud
Charles Leclerc x Verstappen!Reader
Summary: Max thinks it’s bad enough that his sister is dating his emotional support rival … but did they really have to rub salt in the wound by making him want to puke on national tv?
Warnings: 18+ content mildly implied
You take a deep breath as you walk onto the Family Feud stage, trying to calm the butterflies in your stomach. You never expected to be here, about to face off against your brother and his Red Bull Racing teammates in a battle of wits. But when Fred Vasseur talked to you about potentially doing an episode of the show for charity, you jumped at the chance.
Especially since it meant spending time with your boyfriend.
You glance over at Charles and he winks at you, his smile making your heart flutter.
You could stare into each other’s eyes all day so you force yourself to look away and turn to face the host Steve Harvey as he introduces the teams.
“Welcome to Celebrity Family Feud!” Steve announces. “Today we’ve got two Formula 1 teams ready to compete. Let’s meet the teams!”
Steve starts with the Red Bull Racing team. “We’ve got Team Principal Christian Horner, Red Bull drivers Max Verstappen and Sergio Perez, and AlphaTauri drivers Daniel Ricciardo and Yuki Tsunoda!”
The crowd cheers as the guys wave. Max shifts awkwardly, clearly not comfortable being on stage. You stifle a laugh, knowing he would rather be anywhere than here right now.
“And the Scuderia Ferrari team,” Steve continues, “led by Team Principal Fred Vasseur, with drivers Charles Leclerc and Carlos Sainz, Chief Technical Officer Y/N Verstappen, and reserve driver Antonio Giovinazzi!”
You and your teammates greet the audience. As you pass Max, you ruffle his hair teasingly. “Ready to lose?”
He swats your hand away, rolling his eyes. “You wish.”
Steve explains the rules and then it’s time for the face-off. You and Charles step up to represent Ferrari while Daniel and Max come forward for Red Bull.
“Alright, we surveyed 100 people, top five answers are on the board,” Steve says. “Name something you do to get pumped up before a race.”
You ring the buzzer just before Max. “Listen to hype music!” You shout.
“Listen to hype music!” Steve repeats. “Let’s see if it’s up there!”
You hold your breath as the board flips, revealing your answer in the #2 spot. You and Charles high-five triumphantly.
“Alright, Red Bull, you can steal if you have a better answer,” Steve prompts.
Max thinks for a moment. “Visualize winning,” he tries.
“Good answer, good answer,” Steve nods. But it’s not there. You grin at Charles, knowing Ferrari has taken round one.
The game continues, both teams battling it out trying to guess the survey answers.
You and Charles can’t resist teasing your brother every chance you get.
“What might a Formula 1 driver do to unwind after a long race?” Steve asks next.
You buzz in with a sly smile. “Make love to their partner!”
Charles doubles over laughing as Max makes gagging noises, his face turning bright red.
“Wooowee, let’s see if our survey takers agree! Is making sweet sweet love to their partner on the board?” Steve chuckles. Unbelievably, it shows up as the #4 answer.
“Yes!” You shout, kissing Charles on the cheek. Max is shaking his head, looking like he wants to disappear. You blow him a taunting kiss, which just makes him cringe more.
“Red Bull, you gotta come back from this,” Steve says.
“Uhhh ... play video games,” Daniel guesses but the large red X that appears on the screen shows that Ferrari maintains the lead as you head into the final round.
“Alright, this is for the win. Ferrari just needs 9 points to end this right here,” Steve announces dramatically. “Name something you might find in an F1 driver’s motorhome.”
Charles rings in first. “Condoms!” He calls out, wiggling his eyebrows suggestively.
You laugh as Max lets out an anguished yell. “Stoooooop!”
“Survey says ... number three answer!” Steve announces. “Ferrari wins!”
Charles grabs you in a celebratory hug, spinning you around happily. You kiss him deeply, not caring that Max is fake vomiting behind you.
You break apart from your boyfriend, glancing back at Max still pretending to gag.
“Ugh get a room,” Max complains.
“Don’t worry, we plan to as soon as we get done with this,” you wink.
Max looks utterly disgusted as always.
“Alright folks, time for the Fast Money round!” Steve announces. “First up for Ferrari is Charles Leclerc!”
You blow Charles a flirty kiss as he takes the stage.
“Name something an F1 driver might eat before a race,” Steve begins.
Charles shoots you a shit-eating grin before winking at the camera. “Their beautiful girlfriend.”
You giggle as Max turns an unnatural shade of red alarmingly similar to your Ferrari branded shirt.
“Let’s see if the survey agrees!” Steve turns to the board.
No match but you don’t care.
Charles fires through the next few questions.
“Name something you’d pack for a race weekend.”
“Handcuffs,” he laughs at Steve’s scandalized expression.
You pretend to fan yourself while Max bangs his head against the podium in agony.
The buzzer sounds and Charles finishes strong. You give him a hug as you take the stage instead.
“Name something associated with F1,” Steve says.
“Fast cars and sexy drivers,” you reply with a wink towards Charles.
Charles blows you a kiss. Max looks ready to walk off stage or stab a mechanic with a fork.
You hope it’s the first option. One mechanic stabber in the family is more than enough, thank you very much.
You match Charles’ style, giving mostly normal answers until …
“Name something you pack for a weekend trip.”
You tap your chin playfully. “Lots and lots of lingerie.”
Charles whistles and cheers as you curtsy. Max is nearly crimson with embarrassment.
“And that’s the game!” Steve concludes. “Congratulations to Ferrari for their big win today on Celebrity Family Feud! $46,000 will be donated to Racing For Kids on your behalf.”
You leap into Charles arms, kissing him deeply. “That’s how it’s done, schatje!”
“We make an unstoppable team,” Charles smiles, dimples on full display, and you swear that some of the women in the audience swoon.
Max just shakes his head as he stomps to the exit. “You two need Jesus.”
But you’re too busy gazing adoringly at Charles to notice. Winning the show was fun but the real prize is having the love of your life by your side.
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