Transfer Learning works on the idea that a pre-trained model trained in one setting can be utilized in a different setting for a specific task.
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"Going back in time to recreate the shot that I did in 1967- just mind-blowing," Twiggy says. It's been more than 50 years since she first modeled the Louis Vuitton Papillon bag-as well as accessories similar to the Vacheron Constantin watch and Tiffany & Co. chain bracelet shown here-for the original Bert Stern image and yet "I actually remember the shoot quite well" she says. "It's wonderful to be recreating it."
- Twiggy for Vogue Magazine!
I love this!!! 😭❤️
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Recent advances in large language models (LLMs) and transformers have opened new possibilities for modeling protein sequences as language. Carnegie Mellon University researchers have developed a new AI model called GPCR-BERT that leverages advances in natural language processing to uncover new insights into the sequence-function relationships in G protein-coupled receptors (GPCR), which are the target of over one-third of FDA-approved drugs.
By treating protein sequences like language and fine-tuning a pre-trained transformer model, the researchers were able to predict variations in conserved motifs with high accuracy. Analysis of the model highlighted residues critical for conferring selectivity and conformational changes, shedding new light on the higher-order grammar of these therapeutically important proteins. This demonstrates the potential of large language models to advance our fundamental understanding of protein biology and open up new avenues for drug discovery.
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Teddy loves looking at miniature models. Although he doesn't think about how unsettling a watchdog staring at a town model could be with the whole invasion thing.
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Halloween project 2023!! this one was a challenge but a particularly fun one
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Marilyn Monroe photographed by Bert Reisfeld (1953).
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Jane Birkin and Serge Gainsbourg for Vogue Magazine, 1970
By Bert Stern
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US Vogue November 1, 1962
Sophia Loren
Photo Bert Stern
vogue archive
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Marilyn Monroe photographed by Bert Stern
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Twiggy sitting on a Le Corbusier chair.
Photographer: Bert Stern
Vogue, November 15th, 1967
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