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#pka notes
er-cryptid · 1 year
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pkb-plus · 1 year
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oswalda
greatly resents the winners every time she loses
ojousama laugh. never forget she has an ojousama laugh
feminine style of dress (contrasting starkly against her almost-all fighting-type team)
she feigns a lot of confidence. extremely showy and stuff.
moves around a lot during her appeals, leftover from being an ex-performer
her appeals can be rather weak, focusing more on being flashy rather than her pokémon themselves (again, due to being an ex-performer). even so, she's always really in-sync with her pokémon
you might think she does very well in battle rounds due to her type of choice but (AGAIN due to being an ex-performer) she actually really holds back in battle, even when that's not in-line with her partners. it takes her a while to get used to battling in a way that shows off her fighting-types pure strength.
because of her past (being bullied by other performers. yeah she has a lot of performance-related issues.) she has a really hard time taking criticisms or constructive advice
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kunosoura · 2 months
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This bugs me because it's wrong in the details but right overall. pKa, first of all, isn't the Acid dissociation constant: it's the negative base 10 logarithm of the acid dissociation constant, Ka, which is given by the following equation:
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Where HA is the acid, H+ is the acidic protons it can give off, and a- is the conjugate base or the remainder of the molecule after the proton is given off.
(pH, to note, is also the negative base ten logarithm - in this case, of the amount of h+ ions in a particular solution, in the example springing off of this, the amount of H+ ions in monster energy).
If you have a solution that already has a ton of H+ protons in it, such as monster energy drink, and try to dissolve more acidic particles in it, well, the equilibrium is already very top heavy - so the H+ particles in HA, our acid, will be trying to squeeze into a crowded room, fail, and remain as the undissasociated acid, pushing the equilibrium constant to an even more tiny number than it already is for basically every organic acid. It's a much more complicated relationship than "pKa indicates roughly the pH around which acids can't dissociate" which unless I'm missing something is nonsense - you have to calculate the equilibria constants of these acids with the initial acidity factored it if you want to do anything relating these two values to each other.
It's frustrating because the overall conclusion is right!! for reasons not really related to what they said, the high pH of the monster energy does mean it's more difficult for the acid protons of these acids to dissociate!
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This, however, is just flat out wrong. The lower the pKa value is, the easier it is for that proton to dissociate; this is how negative logarithms work. If you calculate the ratio up above and find that the amount of dissociated species to acid heavily favors the dissociated species, that is a very strong acid, and you will have pKa values that go negative. In most organic carboxylic acids (like those named here), we're looking at a pKa of around 5: meaning that if you dissolve the acid in pure neutral water, how many protons (and conjugate base ions) are in solution compared to the undissociated molecule, you'll get a ratio of about 1/100000 - in other words, a mixture that overwhelmingly does not dissociate.
For secondary/tertiary/so on deprotonations, it becomes progressively more difficult to get rid of those protons, because the conjugate base is already shouldering a negative charge and because the solution already has a concentration of protons. Thus, if you want to say "once this one dissociates then all of the other ones are already dissociated too" you really have to be looking at the highest pKa.
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This part is just goofy. "The trapped acidity of the malic/citric/ascorbic acids is dumped into your mouth" that also happens when you eat the solid candy anyway...
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veganbread1 · 9 months
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Hydroiodic acid (or hydriodic acid) is an aqueous solution of hydrogen iodide (HI). It is a strong acid, i.e. an acid that is ionized completely in an aqueous solution. It is colorless. Concentrated solutions are usually 48% to 57% HI.
IUPAC Name: Iodane
Properties
Chemical formula: HI(aq)
Molar mass127.91g/mol
Appearance: colorless liquid
Odor: acrid
Density: 1.70 g/mL, azeotrope(57% HI by weight)
Boiling point: 127 °C (261 °F; 400 K) 1.03 bar, azeotrope
Solubility in water :Aqueous solution
Acidity (pKa)-9.3
Source Wikipedia
This acid also has a cool almost black colour
(gold anon)
Notes, if behind-closed-doors-ask gets an ask talking about what seeks goop is it should mention HI, b'cos that was me
Hey b-c-d-a hope you didn't find that too weird
YAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAY THANKYOU
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sleepy-gardevoir · 1 year
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march 13, 2023 - monday week 2
i've spent most of my study time today on biochemistry! i transferred my most recent notes into my notion and did the problem set due tonight, but most importantly, i have to know the 20 canonical amino acids, what type each one is, the structure, and the pKa of each relevant site by friday. we're really starting off with a bang! i made flashcards, so hopefully those will help!
i've also got a resume & cover letter peer review to finish and some anatomy and physiology notes to transfer to my notion since i have a quiz tomorrow. i'm enjoying my classes so far, which is good since they all meet tomorrow LOL
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upismediacenter · 2 years
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FEATURE: BTBBTS: Business Throwback and Behind the Scenes
Perhaps you miss the UPIS Fair; or maybe you’ve heard stories about the flurry of commercial and romantic activity in Februaries past. How about the Business Fair? Were you half as enthralled as these shop-obsessed writers were upon beholding their online pubmats? Join us in this lofty undertaking and let BTBBTS recount tales of old trades and demystify the present business climate in UPIS.
—Throwback—
In days long gone-by, both staff and students alike would anticipate jumping from table-to-table to eye arrays of goods touted by students from higher grade levels at the Practical Arts (PA) Pavillion. To the gratitude of teachers at their students’ replenished enthusiasm, classmates of Track and Field (TnF) athletes would be in less danger of dozing off mid-lecture so long as they’d been able to purchase some of the treats proffered to them by their fleet-footed peers in between classes.
From gushing about “cute higher years” manning stalls for their internships, to getting rattled over how the recipient of a Peer Facilitators’ love note might receive one’s sentiments, such reminiscences now seem like the stuff of dreams—viewed from lenses too greatly muddled by the abrading passage of these last two years.
Alas, the pandemic has put an end to many enterprises and events that once all seemed so deeply-anchored in the UPIS experience. To commemorate them and do their memory justice, a detailed throwback is in order.
While the UPIS Fair was one of the most anticipated events for the whole UPIS community, the weeks leading up to it were also some of the busiest and most taxing of the school year. It combined the stress of setting up booths, practicing late into the night for Power Dance (PD), as well as readying oneself for the other events that the pKA had planned. On top of all that, students were also likely to support the overhanging weight of either wistfully wanting or having to celebrate Valentine's.
Such is why a certain club in UPIS made it a tradition to sell small gifts and distribute them amongst the student body—an operation which was highly-favored by students who wished to either surprise their loved ones or maintain anonymity in relating their affections. In the past, the Peer Facilitators Club’s “Cupid’s Express” was everyone’s go-to service when it came to purchasing presents during Valentine's season.
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Arrays of Valentine’s merchandise sold under the “Cupid’s Express” by the Peer Facilitators Club. Retrieved from: https://twitter.com/upispka/status/1095680340792815616?s=46&t=X_bY8iVgd34sk2KyH15CcQ
Their products ranged from stuffed toys to roses and polaroids, the latter having been the most popular amongst couples in school. Another service was actually delivering those gifts to the people whom they were dedicated to.
Days before UPIS Week, some might recall how the club’s members would come up and try to coax fellow students into buying their products. “Hindi naman kailangan i-dedicate sa crush, kahit sa tao lang na ina-admire mo—no harm in making them feel appreciated,” is a line, often accompanied with a wide and assuring smile, that students were more than all too familiar with.
According to Achilles De Leon, a former Peer Facilitators Club member, such inducements were utilized in order to reach their quota. Every member was given order slips and was tasked to sell the number assigned to them by a deadline.
This was to ensure that target sales were achieved without having to do last-minute selling during UPIS week. By then, they would have graduated to another mission—gift distribution. The funds of the club mainly depended on this single event, thus the need for risk-dispelling quota sales.
De Leon said that while stressful, knowing how it would benefit the club later on made it all worth the effort. That in spite of ruing his “lack of salesmanship” and frequent rejection by prospective customers, there’s much gratitude too from all he’d learned.
Sadly, the Peer Facilitators Club has since gone out of order along with all other school clubs because of the pandemic. Clubs were not the only organizations that sold products with the goal of raising funds however; so did some sports teams, but they too have regrettably halted their operations.
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A shirt bought from the TnF team in 2019. Photo credit: Allana dela Cruz
In the past, the Track and Field (TnF) team would sell sweets and shirts in order to raise money for their athletes. They sold all year round, though with greater fervor come UAAP season.
The most popular amongst their edible goods were yemas and cereal bars—some might even recall them being lugged around in big containers. They were often bought during breaks or discreetly distributed when class was taking place. The latter would be much akin to a game of hot potato owing to the wariness of seatmates in dropping their classmates’ change; even conspicuous coin jingling was liable to a teacher’s, “Kaninong pera kaya yun?” Many delighted in the closer proximity to food as it saved them from trips to the canteen. The TnF team also made sure that their snacks were accessible to the entire student populace by providing a seller for each grade level.
Former TnF athlete, Aleah de Castro, said that their shirts’ popularity even extended to members of the students’ families because of the choice to customize and have their surname printed at the back. The organization had a quota of 10 shirts per member, but de Castro remarked that it was an easy feat as some students would buy more than one shirt at a time. She said that her past role in sales led her to learn a lot about business and consumer attitudes—particularly, in knowledge regarding products most sought-after and in the employment of various persuasive maneuvers.
De Castro relayed that she had a lot of fun with the selling—owing in part, she observes, to her past experience in it. She had already been selling cupcakes to her classmates from as early as fourth grade. Desirous she may be to carry it out in limited face-to-face, she is hesitant for fear of her products’ being possible cause for transmission of diseases.
At present, it appears that the only remaining school organization with entrepreneurial undertakings is the Pamunuan ng Kamag-Aral (pKA)—UPIS’ student council. As the student council, their services will continue for as long as there is a student body to lead; it will only ever have “defunct” stamped across its banners should UPIS be so too (and to that, we pray never). While one of its main objectives is to aid in upholding the four core values of Love, Truth, Justice, and Freedom, their business ventures appear to espouse an unratified fifth—School Pride.
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Samples of merchandise from pKA 2018 and 2019. Retrieved from: https://twitter.com/upispka/status/1024248514895695873?s=46&t=6Alc-ewq6ZX1CnF4WaFEKA https://twitter.com/upispka/status/1024233925739085824?s=46&t=6Alc-ewq6ZX1CnF4WaFEKA https://twitter.com/upispka/status/1157969530485764099?s=46&t=uw-rHmQk5w6pQLkBgzq_9w
Prior to the onslaught of COVID, pKA products came in the form of various clothing attire and accessories such as shirts and lanyards embossed with the UPIS logo. They were more or less, as former Vice President Romi Okada would put it, school merchandise. Though generally met with much enthusiasm for their attractive designs, parental zeal was also a primary ascription for particularly successful sales amongst K-2 and Elementary students.
While the supportive community was integral to the student council’s commercial triumphs, chief credit lies within the efforts of its members for their thoughtful planning and strategic promotion via accessible publication material. “The design of the pub for the product really helped; kasi if it's more accessible and easier to understand, more people are going to get attracted,” said Okada.
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The tickets sold by pKA for UPIS Fairs 2019 and 2020. Retrieved from: https://twitter.com/upispka/status/1094217774476345345?s=46&t=X_bY8iVgd34sk2KyH15CcQ https://twitter.com/upispka/status/1226499064444809219?s=46&t=X_bY8iVgd34sk2KyH15CcQ
The pKA trade wasn’t just limited to pursuits in the sartorial however. If the commencement of the school year was devoted to such, its incipient conclusion would see them vending tickets for the school fair—better known as UPIS Days. Earnings would be reserved for funding the succeeding year’s events such as the Leadership Camp (LC)—in which only a lucky few partook—and the aforesaid fair, wherein the organization would also plan for and host multifarious activities, namely: club wars, Power Dance (PD), and the Battle of the Bands (BotB).
Mandatory it may have been, rarely did exertion slacken—noble too, always remained, the student council’s intentions. To quote Okada, “It really taught me that it wouldn’t hurt to go all-out; more funds meant a better outcome or event. So of course more people would enjoy and be satisfied.”
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Last year’s pKA merchandise sold during UPIS Days 2022 “Tanaw”. Retrieved from: https://twitter.com/upispka/status/1518538199764996097?s=46&t=-qPe4m2ONnSpx1IBU8XFbA
For the time being, the pKA business has continued to persist—selling still accessories and articles of clothing that brandish trademark UP icons and phrases. Unlike pre-pandemic procedures wherein most of the income would circle back to their treasury, for pKA 2021-2022, half of the sales went to the Save Our Schools (SOS) network which was dedicated to helping Lumad youth.
In line with their enduring retail, we now take a turn to the present state of the UPIS business situation and those at its forefront.
—Behind the scenes—
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A compilation of the BE strand’s six start-up companies’ logos. Retrieved from: https://www.facebook.com/photo.php?fbid=136251722484762&set=a.136251729151428&type=3
Since many school businesses have gone out of commission, the current UPIS marketplace mostly comprises the trades of student entrepreneurs both extrinsic and belonging to the Business & Entrepreneurship (BE) track. In our current set-up, some might say that the BE strand appears to be somewhat elusive—a collective whose inner workings outsiders are made privy to only through arrestingly persuasive pubmats promoting their sales internships.
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Each company’s solo promotional material for DiskoBErey 2022: Beyond Expectations. Retrieved from: https://fb.watch/g6yTxaR9Pt/ https://m.facebook.com/story.php?story_fbid=pfbid07kSTz1m4499MU3L74QKhYyfAfRpFCzSJmPTMvwzSr2yHtQCgPZwPBmDLyibwJj4kl&id=102315785777322 https://m.facebook.com/story.php?story_fbid=pfbid027sRo1mAU3HS3RTPBVGRmmF5ahcWSan9pVf7Nbb52uck6j3FjY23ZNj7BSsiHq8AXl&id=102315785777322 https://m.facebook.com/story.php?story_fbid=pfbid0Tdb91z1LiAjKvV2eUB3UeEsdvwuxakR5hpZvV33w6cLnK11J7Th5ZxmmimvCoLcLl&id=102315785777322 https://m.facebook.com/story.php?story_fbid=pfbid0V2BmXZ11r74NBVg3bXBssKpSQCAFANgR217Ff3fY6Yu8EMbwCCwWcaJizoA6UcPLl&id=102315785777322 https://fb.watch/g6yYYswwmb/
As of now, the merchants of 12-Kasipagan are in the early stages of production and quality control. They consist of six start-ups: OOTieDye, Lolliloomps, Indie Ocean Co., POV, Beverage Joe, and RelEVENT. In that same order, each offers tie-dyed goods, lumpia desserts, customized t-shirts, tote bags, refreshments, and events management services. They will be up for sale and/or made available to the student body at the BE track’s Business Fair to be held on November 15 to 17.
Launch dates vary amongst the companies. POV’s Production Manager Jasna Seguban says that they’re to start pre-orders a week or two before the fair, whereas Erielle Arceo, the CEO of OOTieDye, has stated that their wares will be made available for purchase from as early as October 18. Both are united in the wish of garnering much love and support from the UPIS community. “We hope that our customers will enjoy POV bags as much as we, the creators, enjoyed turning our product ideas into reality,” said Seguban.
With preparations drawing to a close, and advertising alongside marketing looming ever nearer, it’s important to acknowledge the students’ immense efforts in paving the way, through perennially rocky terrain, for their businesses’ fruition.
According to Arceo, there is no doubt that the pandemic has closed many doors for new businesses. She explains that it’s done away with the possibility of selling their products in person and has posed much difficulty in shooting promotional material.
Notwithstanding, she keeps an optimistic outlook on the situation and believes that certain aspects are preferable and even conducive to advancement in their business. A certain advantage is that rather than having to open up a physical store, they need only to utilize delivery services. And due to the undeniable rise of social media users in recent years, their online presence has led to greater customer engagement—widening reach with their target demographic.
On the other hand, Seguban has admitted that her group struggled considerably with starting a business in the midst of a pandemic. Putting herself in the shoes of her customers, she has shared that she would prefer a physical store so as to properly inspect the products herself.
She is hoping that a smoother flow of production as well as greater ease in communication will ensue with the limited face-to-face mode of learning. For Seguban, up close and personal is more desirable than functioning remotely when it comes to talking to her team or any customers. Further stressing the importance of communication, she relates that, "Ideas would not become a reality if not communicated, and in turn, opportunities would be inhibited.”
For both interviewees, their time in the BE track has been well-spent as it has provided them not just with skills that they can use later on in life, but also with experiences that they otherwise wouldn’t have gained had they gone a different path. They’ve learned how to manage their time and energy with greater discretion—to refrain from worrying about things over which they have no control. But they have also proven that perseverance can be the answer to many things, no matter how impossible the tasks may seem. Everyone should understand that behind every business are individuals who dedicate much of their time and effort in building it.
According to them, the business climate of UPIS appears to be very healthy—one with a generally supportive community of buyers, as well as a diverse range of products and sellers. It’s possessed of enough variety, they say, as to deter very intense competition. They also note that an overlap in themes or products is something they generally avoid.
Both commended their fellow entrepreneurs for how they sell not just for the mere sake of gaining money, but out of genuine concern for their customers as they recognize their potential to provide them with their needs. As entrepreneurs themselves, they never fail to consider their clientele in drawing up every plan. And while up to date with trends, they ensure to integrate their own twists to make them more personalized to their brand. Lastly, they are adamant about how affordability should come hand in hand with good quality.
Because of the gradual transition back to physical classes, both entrepreneurs are positive that small businesses will also return—that it is only a matter of time before more students begin selling to their classmates again once the situation has become the norm.
For any readers who plan on starting their own business, this article concludes with a few words of advice from Miss Arceo. She advises that even though you are determined to go all out with all your plans, taking care of yourself is just as important. "We are not robots that can operate tirelessly and with little maintenance. Care for yourself. Care for your peers. Our mood reflects on our work. Therefore, it is when we, the entrepreneurs, are healthy and happy that our business can also be healthy and thriving!" //by Andrea Almeda and Allana Dela Cruz
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chemistryworldclass · 7 months
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Acidity, basicity, and pKa
Note from the authors to all readers This chapter contains physical data and mathematical material that some readers may find daunting. Organic chemistry students come from many different backgrounds since organic chemistry occupies a middle ground between the physical and the biological sciences. We hope that those from a more physical background will enjoy the material as it is. If you are one…
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frogshunnedshadows · 1 year
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Preview / notice of upcoming Maschinen Krieger / MaK / SF3D / ZbV 3000 / you-know-what-I-mean kits, including the SAFS, AFS mk. I, PKA H0, AFS mk. II, and Fireball. Note the inset diorama / scene, and the MSRPs.
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fieldburns34 · 1 year
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Amino acids free of peptide bonds have peptide bonds?
In amino acids, peptide bonds are often questioned about their freedom. There are two possible answers. a new study from the researchers at Regenics are indeed free and covalent, i.e., amino acids cannot exist without the bond between their peptides. It should be noted, however, that both of these rules have exceptions. a-helix Proteins are often influenced by peptide bonds that influence their structure. By dehydrating two amino acids, these bonds are formed between their amino groups. Peptide links remain relatively planar due to the rigid amide bonds formed by these bonds. In a peptide, each amino acid unit represents a turn. The insulin protein has an average of 54 amino acid units. Occasionally, a protein will not conform uniformly. The cobra venom neurotoxin contains five disulfide bonds, for example. In a tetrapeptide, the left end has a free amine group and the right end has a free carboxylic acid group. Pyro is abbreviated as pGlu. The peptide is arranged along helical axis in this model.
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The A-helix structure is common to most globular proteins. Its pitch is -58°, making it the most stable. Alpha helix consists of four turns with 14 amino acids each. An alpha-helix accounts for three of the total secondary structure of most globular proteins. b-pleated sheet Proteins often have b-pleated sheets. Hydrogen bonds connect these structures. Parallel or antiparallel networks can exist. Fibrous proteins typically have them as structural features. A large number of amino acids have rings in their structures, which are used to build these chains. Helix breakers are often referred to as prolines. As a result, the chain will bend because it disrupts the helices. The R group has an unusual structure that prevents rotation around the C-N bond. Secondaries can be classified into three types. There are different types of polypeptides, each localized to a certain part of the chain. In proteins, there are about 30 to 50 amino acid units per molecule. some ideas contains 36 amino acids on each turn. In amino acids, hydrogen bonds connected their carbonyl carbons and amino Hs are called amide bonds. The end of each peptide has a free -CO- group. According to the number of amide bonds and amide groups, peptides can have two different structures. https://www.unitedfreshfoundation.org/will-a-vasectomy-lower-testosterone-levels/ vs covalent bonds Stabilizing protein structures is much easier with hydrogen bonds than with covalent bonds. It is usually 30-300 times weaker than a covalent bond because it is formed between atoms within a polypeptide. During the production of amino acids, weak noncovalent bonds form between atoms in the side chains of the amino acids. While these bonds cannot form permanent dipoles, they can act in parallel to clamp two regions of a polypeptide chain together. Noncovalent bonds play an important role in protein folding, as well as their functional importance. Amino acids have various chemical properties which may make these bonds ionizable or unionizable. pH and amino acid solvation status influence the strength of the bonds. As a result of weak noncovalent bonds, polypeptide chains maintain a tight tertiary structure. Especially hydrophobic amino acids exhibit this property. An image of peptide bonds represented by a rattlesnake The free amino acid is represented in several different ways. Among these methods are the use of three-letter abbreviations for amino acids. As each letter represents a different amino acid, it will be represented by a different color. A charge and ionization state of amino acids can be predicted using abbreviations. Many factors can affect the pKa values of amino acids. The pH of a solution, for instance, can alter the amino acid's charge. The charge of amino acids may also be affected by temperature. An overview of standard pKa values for amino acids can be found in table 31.1. If pH is two units above pKa, 70% of the functional group will be deprotonated. An alternative method is to represent polypeptides with a polypeptide structure. The amide link connects amino acids in a polypeptide. A nucleophilic attack of the electrophilic carbonyl carbon of one amino acid on the amide of another amino acid activates the amide link. Secondary amines counter nucleophilic attacks by releasing electrons to nitrogen atoms. Regenics 18133 Ventura Blvd Suite C, Tarzana, CA 91356 (818) 515-0091 https://regenics.com/
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polandfrance5 · 2 years
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Outcomes involving Extracellular Matrix Encorafenibg inside Points along with Metastasis regarding Cancers together with Fresh Immunotherapies: An excellent Guarantee for Upcoming Project
These kind of outcomes had been observed in axons coming from the two peripheral as well as neurological system. Our own outcomes declare that your mPTPis an integral effector associated with axonal degeneration, where many self-sufficient signaling pathways converge. Since axonal along with synapse deterioration are usually significantly regarded early on pathological events in neurodegeneration, our operate pinpoints any targeted regarding restorative treatment in a wide selection of problems that cause lack of axons and following functional problems.Signaling by simply mTOR intricate One particular (mTORC1) helps bring about anabolic cellular techniques in response to expansion components, vitamins, as well as junk cues. Quite a few clinical trials medical records mTORC1 inhibitor rapamycin (otherwise known as sirolimus) to immuno-suppress sufferers right after wood hair transplant have got noted the roll-out of hypertriglyceridemia along with elevated solution totally free efas (FFA). All of us consequently looked at the cellular role regarding mTORC1 in control of triacylglycerol (Marking) metabolism utilizing cultured murine 3T3-L1 adipocytes. Many of us learned that management of adipocytes along with rapamycin reduced insulin-stimulated Draw safe-keeping comparable to 50%. To ascertain no matter whether rapamycin lowers TAG storage through upregulating lipolytic rate, all of us taken care of adipocytes in the shortage and also #Link# existence of rapamycin and isoproterenol, any try out 2-adrenergic agonist that will invokes your cAMP/protein kinase A (PKA) pathway to promote lipolysis. All of us found that #Link# rapamycin augmented isoproterenol-induced lipolysis with no changing cAMP ranges. Rapamycin improved the particular isoproterenol-stimulated phosphorylation involving bodily hormone vulnerable lipase (HSL) in Ser-563 (a new PKA site), nevertheless didn't have any effect on the particular phosphorylation involving HSL S565 (an AMPK website). Additionally, rapamycin failed to affect the isoproterenol-mediated phosphorylation involving perilipin, a necessary protein in which jackets the particular lipid droplet to be able to initiate lipolysis after phosphorylation by simply PKA. These kind of information show hang-up of mTORC1 signaling synergizes with all the beta-adrenergic-cAMP/PKA walkway to reinforce phosphorylation involving HSL to market hormone-induced lipolysis. Additionally, making a singular metabolic perform with regard to mTORC1; mTORC1 signaling curbs lipolysis, as a result augmenting Marking safe-keeping.Qualifications Keloids may cause important deaths in the course of wound recovery, though the most common present treatment method techniques pertaining to keloids are certainly not well-established. Objective To discover the major remedies used for keloids in the United States along with demographics of patient visits pertaining to keloids. Methods The National Ambulatory Medical Care Survey for 1990-2009 has been queried regarding visits using a proper diagnosis of keloids. Top medical and also procedural remedies, affected individual market traits, physician areas, reasons for check out, and also comorbidities have been examined. Results There have been around 427,Five-hundred visits annually for keloids, having a small decline in regularity associated with appointments as time passes (p=.001). Triamcinolone had been the best treatment, as well as removal or perhaps devastation of the lesion has been #Link# the best step-by-step treatment. Sixty-two per cent of people ended up women, and also 23.
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er-cryptid · 1 year
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whiskersontherocks · 5 years
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~ ~ make your own way ~ ~
I've struggled with the concept of Acid (or Basic) Drugs and the ionizing changes when dropped in Acid (or Basic) Environments, based on pKa level of the drug.
I also know I do a lot better with visual aids so here's my flipping triangle scales, in case you find it helpful!
Starting with the type of drug (acid or base), and knowing the pKa level of it, you then figure out if the environment is more acidic (or basic) than the pKa level, and go up or down the triangle for the absorption by the administered route:
Parenteral intake? The more ionizing the faster it absorbs so the upper scale of the base side and the lower scale of the acid side
Oral intake? NON-ionizing is better for GI absorption, so upper scale of the acid, lower scale of the base.
It's a mess.
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re-decorate · 6 years
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thelastspeecher · 6 years
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YES HELLO PROFESSOR IF YOU’RE NOT GOING TO GIVE US THE PKA IN THE HOMEWORK QUESTION AT LEAST HAVE THE FUCKING HUMAN DECENCY TO SAY “IT’S IN YOUR NOTES” BC I’M LITERALLY SHAKING WITH ANGER RN
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inkofamethyst · 2 years
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December 16, 2021
[10a]
Biochem exam was okay.  Certainly not great.  I most definitely pulled things out of thin air.  Didn’t talk about hydrogen bonding once except perhaps in a vague sense when I mentioned weak interactions.  Very little of my combined knowledge about those 1.33 mechanisms (out of about four total, I think) helped.  Might’ve weaseled my way into some right answers though.  I still barely understand what a pKa is, but I think I calculated the isoelectric point correctly even if I couldn’t define it.  Ended up sitting behind the guy lol.  Of all the seats in that place, that was the one I ended up in.  Averted my gaze hard when he got up to turn his paper in.  With any luck, I’ll never run into him again on this big ol’ campus.
Not feeling the need for a nap, exactly, but I certainly am tired.  I’ll probably just chill (youtube, CR, etc).  I wish I had some sewing things with me.  I have two meetings today and then plan to organize my physics notes and start reading over the new cell bio lecture slides.  Will likely end up going to bed early.
[7p]
The group chats are abuzz.  Word on the street is there’s a huge uptick in covid cases on campus as of, like, yesterday.  The lines in this area for covid testing are, according to the grapevine, long (though I suspect it’s filled with students who want to possibly take their final online).  The dining halls have switched to carryout only as of this afternoon (which is unfortunate because I’d planned to get one last stir fry meal tonight).  A number of profs are moving exams online (which would suck if my uni decides to mandate it and the only in-person exam I have was also my hardest one :/).  There’s even questions milling about related to whether we’ll still be able to hold the concerts this weekend.
dang.  imagine first losing the solo and then the concert as a whole.  idk how I’ll cope going another semester without a big stage performance of some sort that I’ve prepared weeks and weeks and weeks and weeks for.  and not just me.  this is a 100+ person ensemble.  I was so excited to do this really cool thing that I’ve never really done before.  I mean I suppose I still am, as it hasn’t been cancelled yet, but the odds are not looking great.
[8p]
I’ve been switching between groupchats, “listening” to people chatter on in mild panics off-and-on over the course of the last hour and it reminds me a lot of the final hours before we all got notifications that we were being sent home back in March 2020.  It’s frantic.
[10p]
One of the group chats swung so far into panicking about how if they took the final in-person they would transmit covid to their aunt’s boyfriend’s dying dog with cancer (granted, I’m exaggerating, and there are legitimate concerns that they raised) that some people began sarcastically wishing the virus onto the professor.
I’m actually really tired rn.  Got a trip to a museum tomorrow with my parents followed by a physics exam in the evening.  Might also do my anth exam after that one.  Unless I study for cell bio after physics then take the anth exam on Saturday after the cell bio exam.  That may be the best option.
Today I’m thankful that uh that uh that the end of this semester draws nearer with every passing hour.
[edit: LOL THE WAY I GOT A 30/30 ON THAT TRASH LAB NOTEBOOK]
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hannigramficrecs · 4 years
Text
Outsider POV
In the Truly Gruesome Do We Trust by sidnihoudini [words: 9,473]
Hannibal and Will have murder husbands mind palace sex, and Alana watches obsessively. A slow, sneaky grin slides its way across Will’s face as he looks up at Hannibal and teases, “You enjoy being watched.” “Does a lion eat its prey while it is still alive?” Hannibal asks rhetorically, an amused quirk to his lips. 
Mise en Place by WrathoftheStag [words: 1,858]
What was the cooking staff thinking when that entire pre-dinner party scene went down between Hannibal and Will in Sorbet? Written from their POV. Pining and cooking.
TKO by sidnihoudini [words: 16,906]
Molly deals with the aftermath.
Dissolving Like the Setting Sun by PKA [words: 3,422]
In this universe, Will doesn't suffer from encephalitis, but from a prolonged heat sickness. When he visits Hannibal with Abel Gideon in tow, things escalate.
In Sickness and in Health by BonesAndScales [words: 67,450]
Everyone knows that Will and Hannibal are married. Not everyone knows that they are married to each other.
You're Not Subtle by orphan_account [words: 1,423]
Five times Will and Hannibal fool nobody, and the one time someone calls them out on it.
As Am I by WrathoftheStag [words: 1,671] 
Alana finds out Hannibal and Will are dating. She's not happy about it.
Homewrecker by teacupsandtime [words: 4,111]
An old acquaintance of Hannibal's is in town and finds out he's gotten married since they last saw each other. Later, she sees Hannibal and a scruffy stranger out at a dingy bar and assumes Hannibal is being unfaithful to his pristine, perfect husband.
Ville-Lumiére by KareliaSweet [words: 1,650]
Will says to Molly "I'll be different when I come back."Or Molly's reaction to seeing Will post s3-finale.
A Damn Slippery Life by Magical_Destiny [words: 2,888]
After “The Wrath of the Lamb,” Molly drifts off to sleep beside Will’s hospital bed…and wakes to find herself face to face with Hannibal Lecter.
Jolene by without_a_license [words: 1,350]
Hannibal and Will are moving out of the country. Alana begs Hannibal to leave Will behind.
Alana Finds Out by victorine [words: 32,169]
A series of one-shots in which Alana Bloom discovers, in the midst of various tropes, that her boyfriend Hannibal Lecter's feelings for Will Graham run far deeper than friendship. Basically a chance for Alana to shout at the pair of emotionally-repressed idiots whilst still indulging in much Hannigram loveliness.
Honeymoon by sidnihoudini [words: 3,938]
It’s practically a family reunion, Bedelia muses to herself, as her head lolls to the side, compliments of Hannibal’s disco pharmacologist.
The Shattered, Reassembled by GoldenUsagi [words: 1,581]
Months after Will and Hannibal disappear, Molly receives a final, though not entirely unwelcome, visit from a very different Will.
Still Going Strong by Anica [words: 5,496]
Three times Hanni was upset by his fathers' displays of affection for each other and the time he wasn't.
Importance of Knocking by Anica [words: 4,658]
The three times Hanni walked in on his parents having sexy/kinky time. Or why Hanni's parents always insist on knocking.
A Proposal's Refusal by LazyBaker [words: 1,334]
Peter has a conversation with Jack Crawford concerning one not-so-dead Will Graham.
Collateral Damage by quenchycactus 
They are kept on complete opposite sides of the BSHCI, under Alana’s watchful eye.
Cello Suite No.1 in G by DarkmoonSigel [words: 2,357]
Franklin gets an eyeful and learns about the existence of predators.
Barcelona by Curiousforever [words: 11,682]
In which Molly spots the couple three times, and witnesses the three different aspects of their relationship, not always on light and idyllic notes. They are on a romantic trip now, and so is Molly...in Barcelona. The couple via Molly's perspective, while she is going through her personal revelations regarding their relationship and her past relationship with Will.
Better the Devil by xzombiexkittenx [words: 1,515]
Missing scene from Digestivo. Alana, Margot, and Hannibal rescue Will and get Mason's sperm.
Lontano by cavaleira [words: 3,389] 
Five years later, Alana sees two familiar faces that she hoped to never see again.
Watching by hunted [words: 1,013] 
Alana finds out about their affair, but not by accident.
Millihelen by harleygirl2648 [words: 2,615]
Outsider POV to Hannibal and Will's new life together. Or, Will Graham is not the bait this time, but Hannibal is.
Professor Graham's Cheekbones Hotty & Extraordinary Foodie Husband by TheSilverQueen [words: 3,320] 
Online classes due to the quarantine are how Professor Graham's students learn that: 1) Professor Graham has a cute dog; 2) Professor Graham is married; and 3) Professor Graham's husband is smoking hot.
The Genesis by viaorel [words: 6,736] 
It all started when Alana Bloom, a social worker in an orphanage, was given a task to accompany a renowned married couple willing to adopt. What she did not suspect, however, was that all had been premeditated and taken care of long before the sleek black Bentley pulled up at the doorstep of the institution. And thus began her fall down the rabbit hole that would either destroy her or lead to a liberating genesis.
Pushing Us Into Self-Destruction by IBegToDreamAndDiffer [words: 16,538] 
Clarice Starling needs help with a case, so she pays a visit to Will Graham, who's incarcerated in the Baltimore Sate Hospital with his partner.
The Breath of Sun by Snerp [words: 10,203] 
Will and Hannibal met each other one fateful night in New Orleans. They get violently married, consummated in the river of blood and bone, in the flesh of the monsters of men. They are faithfully married, but not many know they are married to one another.
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