So many skk fanfics have Chuuya be the one that openly shows affection while Dazai is emotionally constipated and while Dazai IS emotionally constipated have you seen them?? Dazai is out there giving Chuuya touching farewell speeches and Chuuya gets so embarrassed he shoots Dazai in the face. They're both so bad at showing care in ways that aren't actions but like Chuuya is EXTRA bad. The most physical affection he's given anyone is like, the fistbump he gave Dazai's shoulder that one time. You're telling me Chuuya is the one openly discussing feelings in this relationship?? Dazai will probably get two words in and Chuuya's already running for the hills. I can't imagine him even hugging people unless someone else initiates.
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I like the headcanon that Wolfwood has enhanced senses from the Eye of Michael's experiments, because it puts such a great twist on his "cool guy" sunglasses and smoking. He's happy to let everyone think it's an affectation, and not that his vision is too sensitive without the dark lenses filtering things out, or that the cigarettes help blunt his sense of smell and taste so he isn't constantly picking up on the tang of gunpowder and blood.
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I really ought to finish these damn Transferrin Saturation paper notes but I'm struggling with the line-by-line horror stories of how fucked up it is.
Like phew I don't even know what's worse:
• Transferrin Saturation as an indicator of Hepcidin production (oop)
• >50% Transferrin Saturation exposure associated with joint symptoms
• High Transferrin Saturation (>50%) also associated with the appearance of NTBI (Non-transferrin bound iron), which is likely linked to things like *organ damage*
• Therapeutic Phlebotomy treatment linked to an INCREASED iron absorption after procedures because (somehow. I haven't found exactly HOW yet) it decreases Hepcidin production.
It's such a fucking hot mess like what do we even DO with this information??? There's no hepcidin synthetics from a few (admittedly quick) googles (I *did* check the clinical trials website and nothing of interest/help). The paper in question talks about how a Melbourne study suggests that it may be more beneficial to *NOT* treat mild cases of iron overload. Which I find wild because the same paper also points out that a low ferritin does not mean you have a low transferrin saturation, and it's exposure to a high TS% over a long period of time that seems to be associated with worsening symptoms (particularly joint pain, ability to do work, athletic ability, and libido).
From my brief googles, there's no easy lab tests for Hepcidin. There's no easy lab tests for NTBI. These are things that could be doing who-knows-what and we can't even tell.
Add to it the whole Estradiol/Hepcidin link and it just all is an absolutely hot mess and do not like the implications of where this leads nor the fact that it seems very few people in research world have looked at this. (I'm not surprised. I'm not fucking surprised. They love to run with the myth that women with haemochromatosis are protected by their periods. In the words of a specialist I absolutely loathed, "you're self medicating with periods". Yeah. Sure. Tell that to my 18 year old self. Tell that to anyone who either knowingly or unknowingly is taking a Contraceptive Pill that has iron tablets instead of sugar placebos. [Because I only just found out THAT is a thing. I was always so worried about what's in the hormone tablets, but this was a whole new level of 'wot'].)
I'm rambling because I keep stopping every couple of sentences. This paper goes hard. Sure it's not perfect and there's a lot of unanswered questions too but there's plenty of food for thought and ooooh boy I'm sorry Dr Haemotologist Sir, it's gonna be one hell of an introduction session.
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Big Ol Mako Momma Baps. The Biggest, Baddest, Sloshiest Baps around.
And the Gigaton Pancake Presser Buns!
And of course: Ultra-Powerful, Voluminous, Jovian Gut. Noisy, Gurgling Thunderous Tummy.
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I forget why, but I was on the Wikipedia page for polycystic ovarian syndrome, and I started researching hirsutism in women, and I learned the following things in this order:
there's a diagnostic criteria used to evaluate how hairy a woman is
This is important because being too hairy is a diagnostic criteria of most disorders that cause hyperandrogenism
Disorders that cause hyperandrogenism can be diagnosed by...measuring how hairy you are (this is the main and most important diagnostic criterion for PCOS)
Disorders that cause hyperandrogenism are important because they are correlated with obesity, infertility, and...being too hairy?
I think to myself, wait, what is a normal range for testosterone in women? I find this article...which set reference ranges for "normal" testosterone levels in women...EXCLUDING WOMEN WITH PCOS?
Quote: "Polycystic ovary syndrome (PCOS) is another notable condition in genetic (XX) females, which is characterized by excessive ovarian production of androgens. This condition is included for comparison with DSD, as the affected females with PCOS are genetic and phenotypic females. The elevated levels of testosterone in these females can lead to hyperandrogenism, a clinical disorder characterized variably by hirsutism, acne, male-pattern balding, metabolic disturbances, impaired ovulation and infertility. PCOS is a common condition, affecting 7%-10% of premenopausal women."
So: the study claims to demonstrate a clear distinction between the normal range of hormone levels in "Healthy" men and "healthy" women...with "healthy" being defined in the study as...having hormones within the "normal" range.......................
So I researched what the clinically established "normal" range for testosterone in women is
THERE ISN'T ONE????
Quote from the above article: "Several different approaches have been used to define endocrine disorders. The statistical approach establishes the lower and the upper limits of hormone concentrations solely on the basis of the statistical distribution of hormone levels in a healthy reference population. As an illustration, hypo- and hypercalcemia have been defined on the basis of the statistical distribution of serum calcium concentrations. Using this approach, androgen deficiency could be defined as the occurrence of serum testosterone levels that are below the 97.5th percentile of testosterone levels in healthy population of young men. A second approach is to use a threshold hormone concentration below or above which there is high risk of developing adverse health outcomes. This approach has been used to define osteoporosis and hypercholesterolemia. However, we do not know with certainty the thresholds of testosterone levels which are associated with adverse health outcomes."
What the fuck?
What the fuck?
It's batshit crazy to make a diagnostic criteria for medical disorders by placing arbitrary cutoffs within 2-5% of either end of a statistical distribution. What the actual fuck?
"The results came back, you have Statistical Outlier Disease." "What treatments are available?" "Well, first, we recommend dietary change. You should probably stop eating so many spiders."
Another article which attempted to do this
Quote: "Subjects with signs of hirsutism or with a personal history of diabetes or hypertension, or a family history of polycystic ovarian syndrome (PCOS) were excluded."
"We're going to figure out the typical range of testosterone levels that occur in women! First, we're going to exclude all the women that are too hairy from the study. I am very good at science."
Anyway I got off topic but there are apparently race-specific diagnostic tools for "hirsutism." That's kinda weird on its own but when I looked more into this in relation to race I found this article that straight-up uses the term "mongoloid"
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