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reasonsforhope · 7 months

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"For the first time, genetically modified pig kidneys provided “life-sustaining kidney function” during the course of a planned seven-day clinical study—a first step in addressing the critical crisis worldwide of kidney donor organ shortage.

The University of Alabama’s pre-clinical human study at Birmingham also advances the science and promise of xenotransplantation as a therapy to potentially cure end-stage kidney disease—just as a human-to-human transplants can.

“It has been truly extraordinary to see the first-ever preclinical demonstration that appropriately modified pig kidneys can provide normal, life-sustaining kidney function in a human safely and be achieved using a standard immunosuppression regimen,” said UAB transplant surgeon scientist Jayme Locke, M.D., director of UAB’s Comprehensive Transplant Institute and lead author of the paper...

The peer-reviewed findings published last month in JAMA Surgery describes the pioneering pre-clinical human research performed on a recipient experiencing brain death...

The pre-clinical human brain death model developed at UAB can evaluate the safety and feasibility of pig-to-human kidney xenografts, or transplants, without risk to a living human. It is named for transplant pioneer Jim Parsons, an organ donor whose family generously donated his body to advance xenotransplant kidney research, like the latest patient did.

A Critical Need

Kidney disease kills more people each year than breast or prostate cancer, while more than 90,000 people are on the transplant waiting list. More than 800,000 Americans are living with kidney failure and 240 Americans on dialysis die every day. The wait for a deceased donor kidney can be as long as five to 10 years, and almost 5,000 people per year die waiting for a kidney transplant.

Groundbreaking Study Details

The 52-year-old study subject for this research lived with hypertension and stage 2 chronic kidney disease, which affects more than one in seven U.S. adults, or an estimated 37 million Americans. As part of this study, the subject had both of his native kidneys removed and dialysis stopped, followed by a crossmatch-compatible xenotransplant with two 10 gene-edited pig kidneys, or UKidney.

The transplanted pig kidneys made urine within four minutes of re-perfusion and produced more than 37 liters of urine in the first 24 hours. The pig kidneys continued to function as they would in a living human for the entirety of the seven-day study. Also, the kidneys were still viable at the time the study was concluded.

“In the first 24 hours these kidneys made over 37 liters of urine,” said Dr. Locke. “It was really a remarkable thing to see.” ...

Gene editing in pigs to reduce immune rejection has made organ transplants from pigs to humans possible. The natural lifespan of a pig is 30 years, they are easily bred, and they have organs of similar size to humans. Genetically modified pig kidneys have been extensively tested in non-human primates, and the addition of UAB’s preclinical human research model—the Parsons Model—now provides important information about the safety and efficacy of kidneys in human transplant recipients."

-via Good News Network, September 17, 2023

#organ donation #organ donor #organ transplant #medical news #medical research #pigs #kidney transplant #kidney diseases #dialysis #good news #hope #hope posting #human biology

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outletcrash · 7 days

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My poison ivy! I'm extremely proud of this. backstory under the cut :)

its been in the back of my head that ivy is indian since forever. i literally have no clue why its just There. she's tamil specifically, because i have favoritism regarding the script its written with.. it tickles my brain...

anyways heres my Poison Ivy: Origins comic i made last night in like 3 hours.

(theres a section here on her early life and the backstory of her parents that im still workshopping. basically she was a bastard child that only her mom supported and they left for gotham)

Bhavani got a job as an accountant for a law firm on recommendation from an uncle who had a company that worked in Gotham (he was kinder to the pair). She was always gifted in math. Bhavani raised her daughter the best way she knew how, even without the support of her family.

Pamela (now nicknamed Ivy due to multiple kids misreading her last name as Ivy. And she was very nature-focused even as a kid, digging in the dirt and identifying different kinds of trees using books she got at the Gotham Library with her mother) excelled in school, surpassing most of her peers. The pursuit of knowledge was the one thing she enjoyed. Her classmates were sticky and loud and irritating, and when she wasn’t ignoring them she was tying their shoelaces together as revenge for talking too loud during quiet time. She managed to make just enough casual friends to not worry her mother too deeply, but this was the start of a downward spiral.

She lost friends, and not many could take on the effort of befriending her. She lost herself in biology, the study of life. Especially plants and conservation. Plants were just so… simple, compared to human society. But their structures and functions and genetics were fascinating. She skipped grades to take higher-level classes on genetics. Her grades were phenomenal but her social skills were extremely underdeveloped. Not like Ivy cared. Humans were a plague on this earth, pumping the atmosphere with CO2 and poisoning rivers and cutting down forests. In her mind, they did nothing but harm the serenity of nature she so cherished.

After graduating with a PHD and doctorate, she got a job as a genetic engineer. She studied alternative ways to help regrow ecosystems after deforestation. Her Gotham University coworkers were wary around Ivy. She was a woman none of them knew anything about, who would say ecoterrorist-aligned comments offhandedly the few times she ever spoke.

Ivy was working on a genetically engineered plant on the day of the accident. It was designed to nurture plant species by sending chemical signals, and it took in energy through waste products left by deforestation and manufacturing. At least, in theory.

Ivy was working all alone in the lab at 2am. She hadn’t slept for hours, she was so close to her breakthrough. She was so close to making those billionaire bastards pay for what they did to the earth. She wasn’t wearing proper safety equipment nor using proper containment procedures during the incident. And as such, she was infected. The plant didn’t just take in waste material, it took in living flesh. Ivy’s cells were transformed in a gruesome fashion, her entire genetic code was re-written as it spread through her body. Her skin was green and her lab coat was bloody. Her newly-red hair flowed behind her as she escaped the lab, running through university grounds. Each footstep brought grass and dandelions cracking through the concrete in full bloom. Trees and grass grew to get closer to her, reaching for her.

Ivys powers were completely out of control. She was crying and hyperventilating as her mind was warped. It had given her a need for flesh. When she made it to Robinson park, she couldn’t overcome the primal instinct. Plants still crawling at her ankles, and she killed a squirrel with her bare hands and ate it raw. This only fueled her fractured mind to want more. Ivy's first ever murder was a pedestrian, who just happened to be in the wrong place at the wrong time. He tried to flee when he saw a bloody green woman with a squirrel carcass in her mouth, but it was to no avail. He was strangled to death with poison ivy vines, and eaten.

Finally, the primal instinct was satiated. Ivy escaped to a warehouse in the industrial district of Old Gotham. She tended to her injuries as best she could, soon discovering she had healing abilities. The injuries from her being torn apart had already mostly healed. She slept on an old couch, dreaming about what she could use these powers for.

When the news broke on the mysterious and grisly death of a random pedestrian, the media was all over it. Since he was killed by poison ivy, and from security footage the culprit was seemingly a woman, the media dubbed her Poison Ivy. Many believed it wasn’t possible, and that the footage was faked, but the GCPD was stumped.

Batman looked through the footage and, by process of elimination (matching the appearances of the scientists who had access to the laboratory, keycard scanners throughout that day and evening, as well as their known affiliations and potential criminal history. Two of them did deal weed but it was nonviolent and they didn’t match the woman in the tapes.)

Dr. Pamela Iyer was the clear suspect. She matched the woman's appearance (besides the green skin and hair, she was a tall woman with long straight hair and a flat nose.) Batman interviewed her coworkers and found she had a history of being antisocial with eco terrorist beliefs. None of them knew where she lived, however. And when the bat interviewed her mother (the only person her coworkers had ever heard her speak to in a positive light) she was very concerned. Suspicious of Batman, clearly, but worried for her precious daughter's well being. She said that Pamela had always loved being near nature, and that she didn’t care for the quality of structure she had to stay in. But other than that, her mother couldn't help. She does bring out the intimidating motherly stare at Batman, making him promise to bring her daughter home safely.

From here, Batman goes on a search. He prowls rooftops and streets and uses the grappling hook for fast travel. All while monitoring city-wide security cameras (thanks Alfred!) and paying attention to police radio. He stops muggings and thefts and helps get a cat out of a tree as he scans Old Gotham.

He came to the conclusion Poison Ivy must be in Old Gotham due to damage on the Robinson Park Bridge, connecting Somerset with the southern island. The damage matched with what had been seen on the sidewalks and streets near the University and the scene of the crime. Dandelions and crabgrass taking the shape of human footprints, cracking through concrete. Batman notices some trees down a certain alleyway in the east streets are warped inwards. Very similar to the trees in the park and university. He follows the unusual growth pattern of the trees, like they were hands outstretching to reach a light source.

There, he finds an old warehouse. He scales the building with a grappling hook, not wanting to be ambushed on the lower levels if he enters on the boarded up front door. Entering through an old broken skylight, he finds what must've been a long abandoned drug dealer hideout covered in fresh blood. Very, very carefully, he examines the scene. But there's nobody there. She just got away, her blood on the rotting old sofa is still warm. He also notes three strands of long red hair, which he places in crime scene baggies for DNA analysis.

His current theory is that the doctor was mutated by her own research. He read her notes and the plant she was experimenting with was extremely dangerous. And the security footage (before it cut out during what he believes was the time of the accident) showed her using improper safety equipment.

He’s on patrol for hours, but can’t find any sign of her.

That night, Bruce synthesizes a pesticide-like chemical that could prevent Ivy's powers. However, he talks to Alfred about how the plant would adapt to it almost like a bacteria, and that it might not be effective more than once.

The next morning Bruce Wayne is scheduled for a charity event. Many rich people are there tied to a business venture Wayne was not aware of. The event was for funding for healthcare systems in Gotham. Little does he know, this is the exact place Ivy plans to attack. She’s hated the rich for years and many politicians and businessmen that support an amazon rainforest deforestation project are there.

She interrupts their little charity event at a historical building in the financial district of old gotham with a surprise. Ivy broke into one of her old greenhouses at the university, taking small samples of extremely poisonous amazon rainforest plants with her. This happened quickly and silently while Bruce was still at the function.

Ivy crashed through the large art-nouveau stained glass windows, supported by giant vines. She is lifted down the staircase like she was floating, more vines and deadly plants crawling in from the giant hole in the glass, moonlight from the full moon peeking through the clouds and illuminating her entrance. London Planetrees from around the building grow in front of doors, sealing all the possible exits.

All of the rich and fancy people in dresses and suits meandering around the building are screaming and trying to run, which is when a mad-with-power Ivy releases her plants.

They grow to gargantuan sizes in moments, releasing toxic spores and fumes and burning people's skin. Ivy finds the most heinous offenders of the rainforest bill and feeds them deadly plants by hand, graphic symptoms ensue.

In the pandemonium, Bruce pulls out some tree facts about the flammability of a certain species, managing to throw a fire source directly at it as a diversion before escaping through a vent in the opposite wing of the hall. Alfred is already outside with the Batsuit, he brought it as soon as he learned of the attack.

Bruce suits up and re-enters. It's a grueling and difficult battle, the most difficult he has fought so far. He manages to spray Ivy with the chemical, and she goes down, all the plants in the hall going still. The excessive toxic fumes suddenly go back to normal levels. Bruce uses an extremely strong tranquilizer on her, she’s still fighting to get up. Finally, Ivy is defeated.

Almost the whole charity gathering was injured in the attack with seven people dead and immense damage done to the structure of the historical hall.

Ivy’s powers are sedated and she’s taken into police custody, where she is deemed insane. Half of the insanity conviction was her actual insanity and the other half was that Arkham is the only facility capable of holding her, especially since it’s located on an island. Batman agrees with Jim Gordon on this comment.

Ivy didn’t say anything during her trial, silently glaring with little remorse. The physician diagnosed her with ASPD (which wasn’t right but it's on her legal documents.)

The comic ends with Ivy in Arkham, talking about the rich swine tearing apart the world, and how she finally has the power to stop them. How she can feel the mutation inside of her slowly winning against the sedative drugs, adapting and consuming the chemical to turn it into energy as it was designed to do. How she will return the world to ecologic harmony, with her own hands. It ends with her in the Arkham cafeteria, staring at a mysterious blonde prisoner a few tables across…

the writing isn't like, a fanfiction. its a guideline for a comic in a series of origins comics im planning. do not get your hopes up these'll be done in like, 10-20 years at my current speed. i have a scarecrow and riddler outline in the works, and plans for a batman, joker, harley quinn and probably a penguin comic eventually. and more villians. once i'm done with all the origins comics i'll be doing like, a regular batman series. just for fun yknow.

#poison ivy #pamela isley #the blonde woman was harley this is 100% a harlivy endgame universe #dc fanart #gotham rouges #harlivy #dc #poison ivy fanart #this plant creature and this gay girl wanna FUCK #ivys the type of fucked up fool to get gender euphoria from being called a critter. an organism even #just like me fr....#harley steals blood donor bags from local hospitals on ivys birthday its like cannibal wine tasting #ivys a cannibal she has to eat raw meat but she doesnt have to eat human meat #its like 2 birds with one stone to her yknow

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