(¸.• ♛ → she gave a bite to her food and then looked at the person that was sitting next to her. "you should give this a try, it's pretty good, those fries are amazing."
@devilsmenu (irene)
11 notes
·
View notes
Order up! It’s the Rubicon Crossroads menu!
Rubicross is my JoJo fanpart, and this was a part of a server event amongst other creators. Between the food and the unique character outfits just for this occasion, this was really fun to make!
Tanqueray Speedwagon’s Tuned Fish:
A lovely seafood dish! Available with a wide variety of sauces, spices, and more, to make it taste juuuuust the way you want it to. Take that, piano!
Guinness Speedwagon’s Hi InfideliT-Bone Steak:
The turf to match the surf, a rather large helping of steak that is sure to taste good, no matter how you slice it. My worst pun to date.
Merlot’s Chef’s Choice:
A delicious* serving of meat* lovingly* prepared* from only the finest* of sources. Please just don’t order it I don’t want to get sued.
*(unverified)
Nico Bourbaki’s Sippin’ on Straight Chlorine:
A seasonal special and cameo from my good friend’s fanpart, Chlorine Delirium! A lemon-lime soda with a positively stunning hue that… huh… wait, is this actually just… chlorine? Uh oh.
Corona Kiddo’s Thnks fr th Brgrs:
Nothing much to explain! It’s a damn good burger and fries, with enough condiments to satisfy anyone. It’s simple and good, enough to take anyone down memory lane!
Victoria Kiddo’s Molten “Fall Out” Lava Cake:
While the ice cream may be cold, don’t let that fool you! The hot fudge and warm chocolate cake of this dessert are sure to cause an eruption of remarkably delicious proportions.
The Rubicon Crossroads:
An unholy vat containing at least every single character’s namesake… that being a type/brand of ALCOHOL, baby! Estimated at a 9000% mortality rate and has slaughtered several gods. Currently brainstorming ways to deliver some to Elon Musk and Ron DeSantis.
Enjoy!
4 notes
·
View notes
Study aims
In view of this, therapeutics that target the spike-ACE2 interactions may be a successful line of study. The current study focuses on inhibition of the binding of the spike-ACE2 proteins via the spike receptor-binding domain (RBD) in the context of the D614 spike, the D614G mutation, the N501Y mutation, and the triple mutation K417N, E484K, and N501Y.
The common dandelion (Taraxacum officinale) is a perennial, native to warm temperate zones in the Northern hemisphere, and widely distributed across road margins, fields, gardens and any other open spaces where it is permitted to grow.
It is an edible plant and has a reputation in Europe as a medicinal plant, touted to be useful in the treatment of illnesses affecting the liver and gallbladder, the gut, and the joints. Its safety has been the subject of many new monographs.
This plant contains terpenes, phenolics including coumarins and flavonoids, and polysaccharides. The most abundant phenolic compound was chicoric acid. The roots contain an abundance of the non-soluble polysaccharide inulin.
Inhibition of spike-ACE2 binding
The administration of water-based extracts from plant leaves was found to be associated with efficient and dose-dependent inhibition of spike protein to the ACE2 receptor, when added before or after incubation of the two.
A related plant, Cichorium intybus, also inhibited this interaction but was not so powerful. The concentration at which these were observed to be effective against 50% of spike-ACE2 interactions (50% effective concentration, EC50) was 12 mg/mL and 30 mg/mL, respectively.
The inhibitory effects were traced to high molecular weight bioactive compounds in the extract.
Inhibition of spike-cell surface binding
The researchers also observed that lung cells in culture, expressing the host cell protein ACE2, failed to bind spike when incubated with the extract first. Binding was reduced by 77%, while the high molecular weight fraction alone blocked binding by 63%.
Continued inhibition at 50% was observed at 3 hours, and at 37% for the chicory extract.
[...]
What are the implications?
Natural compounds could yield effective and safe antiviral therapeutics and have been reported for many decades. Compounds like glycyrrhizin show inhibition of the ACE2 receptor. However, they may also produce incomplete occlusion of the RBD contact motif, thus preventing spike-ACE2 binding.
Synthetic inhibitors of ACE2 binding like N-(2-aminoethyl)-1 aziridine-ethanamine (NAAE) also show the same behavior. The antibiotic dalbavancin both binds ACE2 and inhibits spike-ACE2 binding, and effectively inhibited infection by this virus in mouse and non-human primate models.
Pomegranate peel extract also showed 74% inhibition of this interaction, and blocking of viral entry into human kidney cells in culture.
Dandelion extract moves beyond this, with potent inhibition of spike-ACE2 binding, confirmed by inhibition of ACE2-cell surface binding in two different human cell lines.
The study also shows that the variants D614G and N501Y show increased binding strength to the ACE2 receptor of human cells. This failed to reflect in reduced strength of inhibition by dandelion extract, both pre- and post-incubation, however.
These being more infectious strains, such efficacy shown by the extract shows great promise against infection by variants of concern.
Link to the study on bioRxiv (collaboration between University Freiburg - Molecular Preventive Medicine, University Medical Center and Faculty of Medicine AND Technical University of Munich - Institute of Food Chemistry and Molecular Sensory Science)
9 notes
·
View notes
(¸.• ♛ → the girl sighed, looking at the menu for a second and then at the person that was with her. "i don't know what to order, everything looks so good." she commented. "you know what you are going to order?"
@bcrncoldx (prince adam)
1 note
·
View note