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jcmarchi · 1 month

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Atomic-Level Study Captures Frog Toxin In Action - Technology Org

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Atomic-Level Study Captures Frog Toxin In Action - Technology Org

Cryo-electron imaging studies of poison dart frog toxin molecules in action are helping to solve the mystery of why this is among the deadliest natural poisons.

Graphic abstract of Nature Communications paper on binding of poison dart frog toxin to sodium ion channels. Image credit: George Wisedchaisri, University of Washington

Some tiny Amazon frogs defend themselves when threatened by releasing a substance that quickly incapacitates a predator. For centuries, a few Indigenous tribes in Colombia have siphoned this toxin from skin glands on the frogs’ backs to coat blow darts for hunting, because of its power to take down big game.

The poison instantly cramps the muscles in the body and forces the heart into a chaotic rhythm that ends in cardiac arrest. The bright coloring of the frogs warns animals to stay away. Their chemical weapon is called batrachotoxin, a name based on the Greek root word for frog.

“Predators that attack these dendrobatid frogs are paralyzed so rapidly that they can’t clamp down on the frogs to kill and eat them,” said one of the senior researchers on a recent batrachotoxin study, William Catterall, a professor of pharmacology at the University of Washington School of Medicine.

He noted that “it is so toxic that wiping the toxin secretion from the back of a single frog is sufficient to poison several blow darts, which will each immobilize or kill large prey.”

What makes their irreversible toxin more severe, compared with others that also target the signal-producing pores of nerve and muscle cells?

It has long been known that batrachotoxin affects sodium ion channels, which control electrical pulses by regulating the flow of charged sodium particles through the membranes of these cells.

“The toxin acts by hyperactivation of the sodium channel that generates action potentials in nerve and muscle, thereby causing a lethal storm of hyperactivity of nerves, synapses and muscle cells,” Catterall said.

By using high-resolution cryogenic electron microscopy, a research team led by pharmacologists at the University of Washington School of Medicine have determined, at the atomic level, the structure of the toxin derivative batrachotoxin-A benzoate when it is bound to its receptor site on the cardiac sodium channel.

Unexpectedly, the researchers discovered that, unlike other toxins, batrachotoxin actually binds to two separate but similar receptor sites in the cardiac sodium channel. This dual-receptor action, and its multifaceted effects, provide unprecedented insights into why this poison is so effective, powerful and deadly.

The toxin’s unique mechanism for high potency and lethality might also establish a new paradigm that helps to explain the actions of other toxins with high lethality, the researchers suggested.

Such studies might also lead to better therapies for conditions resulting from certain electrical signaling problems in excitable cells and tissues, such as those in the heart, muscles, nerves and brain that are caused by malfunction of a sodium channel.

For example, Catterall suggested, drugs designed to be robust inhibitors at both dual-receptor sites discovered in this study might also be valuable therapeutic agents in the treatment of disorders of hyperexcitability of nerve and heart cells. Such disorders include epilepsy, chronic pain and arrhythmias.

Source: University of Washington

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moremedtech · 4 months

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Inhalable sensors could enable early lung cancer detection

Inhalable sensors could enable early lung cancer detection. The diagnostic, which requires only a simple urine test to read the results, could make lung cancer screening more accessible worldwide. Inhalable particles Accurate diagnosis MIT, January 5, 2024 - Using a new MIT technology, diagnosing lung cancer could be as simple as inhaling nanoparticle sensors and then taking a urine test to see if a tumor is present. The new diagnostic uses nanosensors that can be delivered via inhaler or nebulizer. When the sensors come into contact with cancer-linked proteins in the lungs, they generate a signal that accumulates in the urine and can be detected with a simple paper test strip. This method has the potential to replace or supplement the current gold standard for lung cancer diagnosis, low-dose computed tomography (CT). According to the researchers, it could have a particularly large impact in low- and middle-income countries where CT scanners are not widely available. “Around the world, cancer is going to become more and more prevalent in low- and middle-income countries. The epidemiology of lung cancer globally is that it’s driven by pollution and smoking, so we know that those are settings where accessibility to this kind of technology could have a big impact,” says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and of Electrical Engineering and Computer Science at MIT, and a member of MIT’s Koch Institute for Integrative Cancer Research and the Institute for Medical Engineering and Science. Bhatia is the senior author of the paper, which appears today in Science Advances. Qian Zhong, an MIT research scientist, and Edward Tan, a former MIT postdoc, are the lead authors of the study.

Inhalable particles

To help diagnose lung cancer as early as possible, the U.S. Preventive Services Task Force recommends that heavy smokers over the age of 50 undergo annual CT scans. However, not everyone in this target group receives these scans, and the high false-positive rate of the scans can lead to unnecessary, invasive tests. Bhatia has spent the last decade developing nanosensors for use in diagnosing cancer and other diseases, and in this study, she and her colleagues explored the possibility of using them as a more accessible alternative to CT screening for lung cancer. These sensors consist of polymer nanoparticles coated with a reporter, such as a DNA barcode, that is cleaved from the particle when the sensor encounters enzymes called proteases, which are often overactive in tumors. Those reporters eventually accumulate in the urine and are excreted from the body. Previous versions of the sensors, which targeted other cancer sites such as the liver and ovaries, were designed to be given intravenously. For lung cancer diagnosis, the researchers wanted to create a version that could be inhaled, which could make it easier to deploy in lower resource settings. “When we developed this technology, our goal was to provide a method that can detect cancer with high specificity and sensitivity, and also lower the threshold for accessibility, so that hopefully we can improve the resource disparity and inequity in early detection of lung cancer,” Zhong says To achieve that, the researchers created two formulations of their particles: a solution that can be aerosolized and delivered with a nebulizer, and a dry powder that can be delivered using an inhaler. Once the particles reach the lungs, they are absorbed into the tissue, where they encounter any proteases that may be present. Human cells can express hundreds of different proteases, and some of them are overactive in tumors, where they help cancer cells to escape their original locations by cutting through proteins of the extracellular matrix. These cancerous proteases cleave DNA barcodes from the sensors, allowing the barcodes to circulate in the bloodstream until they are excreted in the urine. In the earlier versions of this technology, the researchers used mass spectrometry to analyze the urine sample and detect DNA barcodes. However, mass spectrometry requires equipment that might not be available in low-resource areas, so for this version, the researchers created a lateral flow assay, which allows the barcodes to be detected using a paper test strip. The researchers designed the strip to detect up to four different DNA barcodes, each of which indicates the presence of a different protease. No pre-treatment or processing of the urine sample is required, and the results can be read about 20 minutes after the sample is obtained. “We were really pushing this assay to be point-of-care available in a low-resource setting, so the idea was to not do any sample processing, not do any amplification, just to be able to put the sample right on the paper and read it out in 20 minutes,” Bhatia says.

Accurate diagnosis

The researchers put their diagnostic system to the test in mice that have been genetically modified to develop lung tumors similar to those seen in humans. The sensors were given to the mice 7.5 weeks after the tumors formed, which corresponds to stage 1 or 2 cancer in humans. The researchers measured the levels of 20 different sensors designed to detect different proteases in their first set of experiments in mice. The researchers identified a combination of only four sensors that was predicted to provide accurate diagnostic results using a machine learning algorithm. They then tested that combination in a mouse model and discovered that it could detect early-stage lung tumors accurately. For use in humans, it’s possible that more sensors might be needed to make an accurate diagnosis, but that could be achieved by using multiple paper strips, each of which detects four different DNA barcodes, the researchers say. The researchers now plan to analyze human biopsy samples to see if the sensor panels they are using would also work to detect human cancers. In the longer term, they hope to perform clinical trials in human patients. A company called Sunbird Bio has already run phase 1 trials on a similar sensor developed by Bhatia’s lab, for use in diagnosing liver cancer and a form of hepatitis known as nonalcoholic steatohepatitis (NASH). In parts of the world where there is limited access to CT scanning, this technology could offer a dramatic improvement in lung cancer screening, especially since the results can be obtained during a single visit. “The idea would be you come in and then you get an answer about whether you need a follow-up test or not, and we could get patients who have early lesions into the system so that they could get curative surgery or lifesaving medicines,” Bhatia says The research was funded by the Johnson & Johnson Lung Cancer Initiative, the Howard Hughes Medical Institute, the Koch Institute Support (core) Grant from the National Cancer Institute, and the National Institute of Environmental Health Sciences. Source: MIT Read the full article

#healthtech #imaging #lungcancer #medtech #medtechnews #MIT

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rosiebutler · 11 months

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ROSARIO “ROSIE” BUTLER. 32 28. sometimes i wonder if i should be medicated, if i would feel better just lightly sedated. the feeling comes so fast and i cannot control it. i’m on fire but i’m trying not to show it.

STATS.

GENDER/PRONOUNS: she/her, ciswoman

OCCUPATION: manager at lucky lasso, housewife, mother

HOBBIES: shopping, manicures, karaoke, drinking, horse-riding, community event planning, gossiping

NOTABLE FEATURES: contracture scars on her back/chest, upper arm. discolouration on the right side of her neck/shoulder/face (no texture change + covered with heavy makeup). hypertrophic scar on hip. facial dimples, shoulder dimples.

FC: priscilla quintana

TIMELINE.

TWs: fire, sibling death, body image, perfectionism.

0-7: A man in love doesn’t see a woman leaving her husband and child for what she is: a cycle waiting to happen. Your mother leaves before you can form words and tell her hi. She doesn’t tell you bye, either. Daddy loves you and your older brother enough for two and works that way, too.

8: The homocidal flame that ate their rickedy apartment brought a paycheque with it. Some of it paid for the grafts and surgeries to fix his daughter’s skin (and the biennial follow-ups), while the rest made them rich. You and your father, that is. Your brother is dead (and it will never be mentioned again).

9-13: Oblivious peers count your frequent days-off lucky. You relish in the false spotlight, but suffer how consistently bodies grow through childhood; skin grafting is painful and it never seems to end. Once, people called you beautiful.

14-18: Beauty is subjective. It’s also flexible. Stuff enough tissue paper down your shirt and you’re the classroom envy. Hundreds are spent on appearance enhancers and daddy’s got plenty and can’t tell you no. Ugly duckling doesn’t grow into her beauty; it is made. Life at the top is glorious and short-lived. The friends you loved and those you claimed to all promised each other a life-long bond. You never hear from them again.

19: Your studies land you outside the state, because the university of california garnered more envy than the local. What sounded like a good idea (a teaching degree) just made you loathe sticky hands. Half through it’s completion, you meet the man you make yourself love and—

20-23: —you make your husband. His lawyer position pays off your unfinished student loan and everything that you learned from it; you try for children. Everywhere needs a lawyer and Whiskey Flats is where you raise them. You live in a two-story home, not an apartment. Life is good.

24-28 (31): Then it’s boring. One girl was manageable. Two, and the depression that comes with it— her, is insufferable. By chance, a friend resorts to you as a fill-in for her understaffed jewelry store. That desperate measure turns into an unexpected (borderline inappropriate) obsession. A sense of control is found behind the counter and the conversation never ends.

28 (32): THE June Watson purchases a store in the center of town. Even better, your lucky stars align and she employs you manager. Working for a beloved, house-hold name trumps any other piece of information in an introduction: Rosie Butler, I work with (for) THE June Watson, married to a loving husband, mother of two bright girls. All those (bitches!) that claimed you peaked in highschool have gone awfully quiet these days.

#fire tw #sibling death tw #body image tw

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lucborell · 1 year

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INTERFACE par luc borell Via Flickr : lucborell est un photophone artiste Lien ci dessous vers ma dernière publication www.blurb.fr/bookstore/invited/7317212/53d5fe3db20ec2e93b... www.facebook.com/lucborell society6.com/lucborell/prints" pinterest.com/lucborell/ mobilhome.tumblr.com/ www.philosciences.com/Pss/philosophie-et-societe/ideologi... Dans un monde de smartphones, les gadgets doivent s’adapter www.internetactu.net/2015/01/14/dans-un-monde-de-smartpho...

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nevver · 2 years

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Korn, Uli Westphal (because)

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nanaluvbug · 1 year

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🧀🥪🌶️🥭 The Ravening War portraits 🧀🥪🌶️🥭

patreon * twitch * shop

[ID: a series of digitally illustrated portraits showing - top left to bottom right - Bishop Raphaniel Charlock (an old radish man with a big red head and large white eyebrows & a scraggly beard. he wears green and gold robes with symbols of the bulb and he smirks at the viewer) Karna Solara (a skinny young chili pepper woman with wavy green hair, freckled light green skin with red blooms on her cheeks. she wears a chili pepper hood lined with small pepper seeds and stares cagily ahead) Thane Delissandro Katzon (a muscular young beef man with bright pinkish skin with small skin variations to resemble pastrami and dark burgundy hair. he wears a bread headress with a swirl of rye covering his ears and he looks ahead, optimistic and determined) Queen Amangeaux Epicée du Peche (a bright mango woman with orange skin, big red hair adorned with a green laurel, and sparkling green/gold makeup. she wears large gold hoop earrings and a high leafy collar) and Colin Provolone (a scraggly cheese man with waxy yellow skin and dark slicked back hair and patchy dark facial hair. he wears a muted, ratty blue bandana around his neck and raises a scarred brow at the viewer with a smirk) End ID.)

#trw #the ravening war #dimension 20 #acoc #trw fanart #ttrpg #dnd #bishop raphaniel charlock #karna solara #thane delissandro katzon #queen amangeaux epicee du peche #colin provolone

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70sscifiart · 11 months

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One of my favorites by Paul Lehr, used as a 1971 cover to "Earth Abides," by George R. Stewart. It's also in my upcoming art book!

#sci-fi art

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389 · 1 month

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PORTO ROCHA

#art #design #ice #cube #block #photography #porto rocha #u

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layla-keating · 1 year

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#thistension

XO, KITTY — 1.09 “SNAFU”

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valley-tulya · 1 year

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(The Sims 4) Estrela Hair

Hair

24 EA Colors

Hat Compatible

55403 polygons

Custom thumbnail

Hair Accessories Overlay

15 Colors Variations

Custom thumbnail

Brow ring category

If you have any issue let me know, enjoy.

T.O.U.

Credits

Download (Patreon - Curseforge)

@maxismatchccworld @sssvitlanz @emilyccfinds

#my cc #ts4cc #ts4 custom content #ts4 cc #ts4cc hair #S4CC #s4mm

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kithtaehyung · 1 year

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AGUST D : DAECHWITA (大吹打) & HAEGEUM (解禁) ⤷ movie posters | ig ; twt (click for hi-res)

#i'm back and ready to create again :'))#bts #bangtan #yoongi #agust d #suga #userbangtan #usersky #bangtanarmynet #hyunglinenetwork #dailybts #*latest #*posters #*gfx #btsgfx #idk if i wanna do an amygdala one #that one seems too personal to edit for me #so these will do for now

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jcmarchi · 2 months

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Mastering PDF OCR Technology with PDFelement - Technology Org

New Post has been published on https://thedigitalinsider.com/mastering-pdf-ocr-technology-with-pdfelement-technology-org/

Mastering PDF OCR Technology with PDFelement - Technology Org

In the fast-paced digital era, OCR editors stand out as the tech wizards of the document realm, wielding transformative powers that turn ordinary PDFs into extraordinary assets. Among these digital platforms, Wondershare PDFelement emerges as a beacon of innovation, offering a comprehensive suite of features designed to elevate the document editing experience. As we embark on our digital adventures, let’s delve into the pivotal roles played by PDF editors like PDFelement and unveil how you can use the platform’s OCR Technology.

One may ask, “how does OCR work”? For starters, OCR technology analyzes the visual patterns of text characters within an image or scanned document and converts them into machine-readable text.

In the context of PDF editing, OCR allows users to extract text from scanned PDFs, images, or other non-searchable documents, making it editable and searchable within the PDF editor. This enables users to edit, format, search, and copy text within PDF documents, enhancing productivity and efficiency in document management workflows.

Advantages of leveraging OCR in PDF editing processes

The utilization of OCR technology in PDF editing offers several benefits, including:

Enhanced Editability: OCR enables users to edit text within PDF documents that were previously inaccessible or non-editable, thereby facilitating document customization and modification.

Improved Searchability: By converting scanned documents into searchable text, OCR enables users to easily locate and retrieve specific information within PDF files, enhancing document accessibility and retrieval.

Increased Productivity: OCR streamlines document processing workflows by automating the conversion process of scanned documents into editable text, saving time and effort compared to manual data entry or transcription.

Preservation of Document Integrity: OCR preserves the layout, formatting, and structure of the original document while converting it into editable text, ensuring the integrity and fidelity of the PDF content.

Before starting your OCR adventure with Wondershare PDFelement, it’s important to know how to properly install the Wondershare platform. Here is a step-by-step guide to installing PDFelement on your local device.

Step 1: Visit the official website of PDFelement and click the download section.

Step 2: The file will automatically download on your local device upon clicking.

Step 3: Navigate to the folder where the PDFelement setup file is located. Double-click the PDFelement file to start the installation.

Step 4: Once installed, you can launch the Wondershare PDFelement platform.

Instructions on activating and configuring OCR within PDFelement

Step 1: After launching PDFelement, navigate to the dashboard and click the “OCR PDF” button to upload and access the OCR functionalities.

Step 2: Configure OCR settings such as language recognition, scan option, and page range according to your preferences.

Step 3: Once OCR is configured, PDFelement will automatically recognize text on your PDF.

Step 4: After the OCR process, you can edit text-based content in your PDF.

Another key point of using OCR is optimizing its performance. Although the feature is significant enough, manually adjusting and enhancing procedures is still necessary. That said, here are some tips you can use to level up the OCR execution on your file.

Ensure high-quality scans: Use a scanner with a high resolution (at least 300 DPI) to capture clear and legible images for OCR processing.

Choose the appropriate language: In the OCR options, select the correct language setting to improve accuracy and recognition rates for text in different languages.

Adjust image settings: Experiment with enhancement settings such as brightness, contrast, and sharpness to optimize OCR performance for scanned documents with varying image quality.

Batch process documents: Use PDFelement’s batch processing capabilities to OCR multiple documents simultaneously, saving time and improving efficiency in document conversion workflows.

To better understand how PDFelement handles PDFs using its OCR feature, here is a detailed guide showcasing each step.

Step 1: Launch Wondershare PDFelement.

Step 2: Click the “+” symbol on the upper left side of the interface and select the “From Scanner” option to initiate the scanning process.

Step 3: Follow the on-screen instructions to select your scanner, adjust scanning settings, and scan the document.

Step 4: Once the scanning is complete, the scanned document will be imported into PDFelement for OCR processing. Please refer to the steps mentioned earlier for configuring OCR.

Step 5: After performing OCR on the scanned document, click the “Edit” tab in the top menu bar and choose the desired editing options for adding, deleting, or modifying text.

Step 6: To extract text from a scanned document, navigate to the “Convert” tab and select the “To Text” option. Choose the output format (e.g., Plain Text or Rich Text Format) and specify the destination folder for the extracted text. Click on the “OK” button to initiate the text extraction process.

Step 7: To convert the document into an editable format, such as Word or Excel, navigate to the “Convert” tab.

Step 8: Click the “Save” button to confirm the saving process and preserve the OCR-converted document.

Tips on Handling Multi-language Documents

To enhance your efficiency during your OCR editing endeavors, here are some suggestions for managing documents containing content in multiple languages.

Purpose/ Application

Useful Tip

Language Recognition Settings

● Ensure your OCR PDF editor, such as Wondershare PDFelement, supports multi-language OCR capabilities.

● Adjust the language recognition settings to include all languages present in the document. Most OCR tools offer a range of language options to choose from.

Separate Processing

● If your document contains distinct sections in different languages, consider separating them before OCR processing.

● Process each language separately to optimize accuracy and avoid confusion between languages.

Manual Verification

● After OCR processing, manually review the text to verify accuracy, particularly in areas where multiple languages may intersect.

● Correct any mistranslations or misinterpretations to ensure the integrity of the document’s content.

Quality Scans

● Ensure that the original document scans are high quality, as this can significantly impact OCR accuracy, especially for characters in non-Latin scripts.

● Adjust scan settings and lighting conditions to optimize text recognition for languages with complex characters or scripts.

Language-specific Fonts

● Use language-specific fonts when editing or formatting text in different languages.

● Some OCR tools may offer font recognition features to preserve the original font style and formatting during OCR conversion.

Tips on Batch Processing

While batch processing can reduce the time required for PDF handling, it doesn’t hurt to have a few helpful tips to enhance the process. Take a look at these suggestions.

Purpose/ Application

Useful Tip

Document Preparation

● Organize and prepare the documents you wish to batch process in advance.

● Ensure all documents are scanned or saved in a compatible format and stored in a designated folder for easy access.

OCR Settings Consistency

● Maintain consistency in OCR settings across all documents in the batch to ensure uniform processing.

● Set language recognition, output format, and other OCR preferences before initiating batch processing.

Test Runs

● Before processing a large batch of documents, conduct test runs with a smaller sample size to verify OCR accuracy and optimize settings.

● Use the results of test runs to fine-tune OCR settings and address any potential issues before processing the entire batch.

Monitor Progress

● Monitor the progress of batch processing to ensure that all documents are being processed correctly and without errors.

● Address any issues or errors that arise during processing promptly to prevent disruptions and ensure the integrity of the output.

Post-processing Review

● After completing batch processing, review the output documents to verify accuracy and quality.

● Manually check a representative sample of documents for any errors or discrepancies that may require further attention or correction.

When processing documents through OCR (Optical Character Recognition), it’s crucial to be mindful of common issues that may arise, impacting the accuracy and quality of the OCR output. Here are some key considerations to watch out for.

Identifying Common Issues

Solutions

Low-quality scans lead to inaccurate OCR results.

Improve scan quality using a higher resolution scanner and ensure proper lighting conditions.

Incorrect language settings cause recognition errors for multilingual documents.

Verify and adjust language settings to match the language(s) used in the document for improved recognition accuracy.

Complex document layouts or fonts affect OCR accuracy.

Simplify complex document layouts or fonts to enhance OCR performance and reduce errors.

Inconsistent formatting or spacing within scanned documents.

Manually review and correct OCR errors using PDFelement’s text editing tools if automatic recognition is inaccurate.

Compatibility issues with certain file formats or scanner configurations.

Update PDFelement to the latest version to ensure compatibility with the latest file formats and scanner drivers.

In conclusion, mastering PDF editor with OCR, like PDFelement, empowers users to unlock the full potential of their PDF editing workflows. By seamlessly converting scanned documents into editable and searchable text, Wondershare PDFelement streamlines document processing tasks enhances productivity, and improves accessibility in document management workflows. With a comprehensive understanding of OCR functionality and optimization techniques, users can easily leverage PDFelement to efficiently handle diverse document types, extract valuable insights, and create professional-quality PDF documents. Embrace the power of OCR technology in PDF editing with PDFelement to elevate your document management experience to new heights.

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moremedtech · 5 months

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NVIDIA BioNeMo Enables Generative AI for Drug Discovery on AWS

NVIDIA BioNeMo Enables Generative AI for Drug Discovery on AWS. Pharma and techbio companies can access the NVIDIA Clara healthcare suite, including BioNeMo, now via Amazon SageMaker and AWS ParallelCluster, and the NVIDIA DGX Cloud on AWS. New to AWS: NVIDIA BioNeMo Advances Generative AI for Drug Discovery Also Available on AWS: NVIDIA Clara for Medical Imaging and Genomics November 28, 2023 - Leading pharmaceutical and biotech companies' researchers and developers can now easily deploy NVIDIA Clara software and services for accelerated healthcare via Amazon Web Services. The initiative, announced today at AWS re:Invent, allows healthcare and life sciences developers who use AWS cloud resources to integrate NVIDIA-accelerated offerings such as NVIDIA BioNeMo—a generative AI platform for drug discovery—which is coming to NVIDIA DGX Cloud on AWS and is currently available via the AWS ParallelCluster cluster management tool for high-performance computing and the Amazon SageMaker machine learning service. AWS is used by thousands of healthcare and life sciences companies worldwide. They can now use BioNeMo to build or customize digital biology foundation models with proprietary data, scaling up model training and deployment on AWS using NVIDIA GPU-accelerated cloud servers. Alchemab Therapeutics, Basecamp Research, Character Biosciences, Evozyne, Etcembly, and LabGenius are among the AWS users who have already started using BioNeMo for generative AI-accelerated drug discovery and development. This collaboration provides them with additional options for rapidly scaling up cloud computing resources for developing generative AI models trained on biomolecular data. This announcement extends NVIDIA’s existing healthcare-focused offerings available on AWS — NVIDIA MONAI for medical imaging workflows and NVIDIA Parabricks for accelerated genomics.

New to AWS: NVIDIA BioNeMo Advances Generative AI for Drug Discovery

BioNeMo is a domain-specific framework for digital biology generative AI, including pretrained large language models (LLMs), data loaders, and optimized training recipes that can help advance computer-aided drug discovery by speeding target identification, protein structure prediction, and drug candidate screening. Drug discovery teams can use their proprietary data to build or optimize models with BioNeMo and run them on cloud-based high-performance computing clusters. One of these models, ESM-2, a powerful LLM that supports protein structure prediction, achieves almost linear scaling on 256 NVIDIA H100 Tensor Core GPUs. Researchers can scale to 512 H100 GPUs to complete training in a few days instead of a month, the training time published in the original paper. Developers can train ESM-2 at scale using checkpoints of 650 million or 3 billion parameters. Additional AI models supported in the BioNeMo training framework include small-molecule generative model MegaMolBART and protein sequence generation model ProtT5. BioNeMo’s pretrained models and optimized training recipes — which are available using self-managed services like AWS ParallelCluster and Amazon ECS as well as integrated, managed services through NVIDIA DGX Cloud and Amazon SageMaker — can help R&D teams build foundation models that can explore more drug candidates, optimize wet lab experimentation and find promising clinical candidates faster

Also Available on AWS: NVIDIA Clara for Medical Imaging and Genomics

Project MONAI, cofounded and enterprise-supported by NVIDIA to support medical imaging workflows, has been downloaded more than 1.8 million times and is available for deployment on AWS. Developers can harness their proprietary healthcare datasets already stored on AWS cloud resources to rapidly annotate and build AI models for medical imaging. These models, trained on NVIDIA GPU-powered Amazon EC2 instances, can be used for interactive annotation and fine-tuning for segmentation, classification, registration, and detection tasks in medical imaging. Developers can also harness the MRI image synthesis models available in MONAI to augment training datasets. To accelerate genomics pipelines, Parabricks enables variant calling on a whole human genome in around 15 minutes, compared to a day on a CPU-only system. On AWS, developers can quickly scale up to process large amounts of genomic data across multiple GPU nodes. More than a dozen Parabricks workflows are available on AWS HealthOmics as Ready2Run workflows, which enable customers to easily run pre-built pipelines. Read the full article

#bionemo #generativeai #healthtech #imaging #medtech #medtechnews #nvidia #technology

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agustdakasuga · 11 months

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The Way Of A Criminal: Chapter 4

Genre: Mafia!AU, Criminal!AU, Angst, Romance

Pairing: OT7 x Reader

Characters: Normal!Reader, Gangster!Namjoon, Gangster!Seokjin, Gangster!Yoongi, Gangster!Hoseok, Gangster!Jimin, Gangster!Taehyung, Gangster!Jungkook

Summary: Your father was a stranger, you never knew who he was and what he did. But one day, someone knocks on your door, informing you of his passing. Now, you learn more about him, his life and the legacy you are expected to continue with the help of his 7 executives.

Story warning(s): This story will contain depictions of violence, blood shed/gore, death, mentions of abuse, smoking, alcohol drinking and gambling. This story is fictional and has nothing to do with real life events or the actual members of BTS. Please read at your own discretion.

Instead of dealing with all this head on, you avoided it. You put everything aside and went on with life, spending all your time doing work, studying and doing your university projects.

Wonwoo noticed this and decided to invite you for a night out. Just a chill night with some drinks. Usually, you would decline, which is why Wonwoo has never invited you out. But you could use the distraction. Maybe being out of the house was good.

DING DONG

“Coming!” You ran down, fixing your earring. You didn’t really know how to dress for a night out like this so you picked a random dress. It was a dark blue, crushed velvet cocktail dress.

“Come on in.” You opened the door for him. Wonwoo smiled, bowing before removing his shoes to come in.

“This dress isn’t really motorcycle friendly, is it?” You let out an awkward laugh, going into the kitchen to get your phone that you left there to charge.

“I didn’t ride my bike since we might drink. I’ll call a cab.” Wonwoo said. He just stood in the doorway, unsure of what to do since it was the first time he was in your house.

“(y/n)?” Wonwoo suddenly called your name, stopping you in your tracks.

“You look great.” He smiled softly.

“Oh... Thank you.” You felt your cheeks heat up at his sudden compliment. He held out a hand to support you as you wore your shoes. After locking up the house, he escorted you to the cab that was waiting for you. And of course, Wonwoo opened the door for you to get in first, being the gentleman that he is. The car ride was silent.

“C-Can I ask you something?” Wonwoo threaded lightly. You hummed, nodding your head.

“I know you like your privacy and I shouldn’t pry but there were this rumours and pictures floating around about some expensive sports car and handsome guy picking you up. Is he one of them?” He asked nervously.

“If by ‘one of them’, you mean my father’s... employees. Yes, he is... or was. There are 7 of them.” You rubbed the back of your neck.

“Are they bothering you?”

“Can we not talk about this anymore? I just don’t want to have to think about it for a few minutes.” That came out a lot harsher and colder than you expected. But Wonwoo didn’t react.

“Sorry. I’m...” You sighed, not really knowing how to piece your words together anymore.

“I understand. Don’t worry about it. I didn’t mean to pry.” Wonwoo smiled comfortingly. Thankfully for you, the cab stopped outside the club. You looked at the long line outside that didn’t seem to be moving,

“Don’t look so worried. My friend put our name on the list so we can just walk in.” Wonwoo laughed. You both got out and he grasped your hand, giving your names to the bouncer. You were so stunned by his action that you just followed him without a word, letting him lead you.

“There’s a table there.” Wonwoo said in your ear on top of the loud music. You were still shocked that he was holding your hand that you just followed him.

“Phew, it’s crowded.” You said, casually pulling your hand away to check if you dropped anything from your bag.

“Yeah, that’s what you get for being here on a Friday night.” He chuckled. You stood at the table while Wonwoo went to get drinks at the bar. The standing table was thankfully at the side of the bar, which meant less people.

“Relax, you’re here to have fun.” You told yourself.

“Here.” Wonwoo got himself a beer and got you a cocktail. It was a nice refreshing drink with flavoured soju as the alcohol.

“Let me know how much everything is tonight and we’ll split the cost.” You told him as you took a sip.

“It’s okay, (y/n). It’s my treat, just enjoy yourself.” Wonwoo smiled. He clinked his glass with yours. Although this wasn’t your exact idea of relaxing, you were glad that the noise and the crowd made the place too loud that you didn’t need to start sharing your feelings. Wonwoo was a good friend but you just weren’t used to sharing so much about yourself with others.

After some drinks, you excused yourself to go to the toilet. But of course, there was a line. About 15 minutes went by without the line moving. You were about to give up when someone grabbed your wrist.

“(y/n) sshi?” You looked at the familiar face.

“Oh... Uh...”

“Yoongi.” He said, letting you go. You nodded your head. Other people in the line now had their attention on you and Yoongi.

“Come.” He nodded over to follow him. You didn’t know why you just went along, not even asking why he wanted you to go with him. You came before a staircase with two guards. But they parted ways upon seeing Yoongi.

“Sir.” They bowed respectfully as Yoongi cooly walked up, hands tucked into his pockets. You quickly bowed your heads back to the guards and caught up to Yoongi.

“You can use this bathroom instead. It’s cleaner and safer.” Yoongi stopped before a door.

“A-Are you sure?”

“If I wasn’t sure, I wouldn’t have went down to fish you out of the crowd. Take all the time you need. This is our own private bathroom so no one else is allowed to use it.” He explained. You nodded, bowing gratefully to him before entering the restroom.

The bathroom was a lot more opulent and grand, with black granite and gold trims. Like Yoongi said, it was very clean, unlike a usual club bathroom. It was definitely a boys bathroom with urinals but you just used one of the stalls.

“Hyung, why can’t I use the bathroom? I really need to go!” You heard voices outside as you were washing your hands.

“Only the 7 of us use it anyway. Unless... Do you have a secret guest in there?!” The person talking to Yoongi gasped as if he just uncovered something scandalous.

“Watch your mouth.” You heard Yoongi threaten.

“Sorry, I’m done.” You opened the door. But you didn’t expect Yoongi to be standing so close that you ended up bumping into his back.

“Oh, no wonder hyung was guarding the bathroom.” The male said. He didn’t mind you and just brushed past to use the bathroom. Yoongi moved you away from the bathroom door, not wanting you to accidentally get hit.

“Thank you. Is it okay if I just stay here for a few more minutes? You can go back to what you were doing before.” You asked timidly. Yoongi took one look at you and nodded. You didn’t need to tell him anything for him to know what you were thinking. The club was getting overwhelming. Yoongi never really liked coming too unless his brothers make him.

“Why did you come if you don’t like it?”

“A friend brought me here as a distraction. Plus, I’ve never really come to a club before.” You replied. Yoongi nodded his head.

“You don’t need to stay and accompany me. I’ll go back down in a bit.” You said.

“It’s okay.” He leaned against the opposite wall. You took your phone out to send Wonwoo a text, assuring him that you were safe and that he could go home first. But you didn’t tell him where you were and who you were with.

“Actually... I wanted to apologise. My brothers told me I shouldn’t have offered you a smoke the other time. I just thought it would help.” Yoongi looked at you.

“It’s fine. I honestly didn’t think too much about it. There were other things to think about.” You shook your head.

“Understandable. I’m sure you have your fair share of confusion and questions that come along with it. This is just the start.” Yoongi said. You didn’t let his straightforward tone faze you, nodding your head glumly.

“Well, I should go. Thanks for letting me hang here.” You straightened up.

“No worries. I’ll walk you down.” Yoongi followed suit. You walked behind him, not sure of the way to the exit. With your insistence, Wonwoo had gone home on his own. You did feel bad for abandoning him when he was the one that invited you out but you also didn’t want him to wait.

“Do you have a ride home?” Yoongi asked.

“I told my friend to go home first so I guess I can get a cab home.” You waved him off, getting your phone out. But Yoongi stopped you, his hand grasping your phone and covering the screen.

“It’s not safe and cheap to get a cab from here at this time. I drank a little so I shouldn’t drive. Hang on.” Yoongi waved over one of the bouncers.

“Use the company car and send her home then report back.” Yoongi ordered.

“Yoongi sshi, it’s really okay.”

“Get the address from her and make sure you see her entering the house before coming back.” Yoongi ignored you. The bouncer nodded and bowed, running off the get the car.

“(y/n) sshi, hyung.” You both turned to see Taehyung jogging over. He had a big, square-ish grin as he waved.

“Jimin said you were here and that Yoongi hyung was with you. Are you driving her home, hyung?” Taehyung tilted his head.

“I drank. So was gonna get one of the workers to drive her back.” Yoongi explained, standing back as he lit a cigarette to smoke. Taehyung nodded his head.

“I’ll drive you home. I didn’t drink since I am the designated driver tonight. Bring my car instead.” Taehyung called out. The worker bowed and ran back into the club. Yoongi decided to go in first after his cigarette was done, not liking being out in the cold. He shot you a nod while you bowed gratefully to him. While waiting, Taehyung put his jacket over your shoulders.

“Did you come alone?” Taehyung asked.

“No... I came with a friend but I abandoned him. Yoongi sshi was kind enough to let me hang out in the quiet area. So I told my friend to go home first.” You said. You didn’t know why you were explaining so much to him.

“This isn’t you scene, is it?” He teased. You pursed your lips and shook your head. The noise and the crowd just wasn’t comfortable.

“Sir.” The car stopped right in front of you. The worker came out, bowing and passing Taehyung’s keys to him.

“Here you go. Watch your head.” Taehyung opened the car door for you to enter. You sat inside, keeping the sides of his jacket close to you so it wouldn’t get caught in the door.

Taehyung confirmed your address before starting to drive. One hand held his head, elbow resting on the door next to him while the other hand was on the steering wheel. During the quiet ride, you fiddled with the hem of the dress, pulling it down every now and then.

“Are you cold?” He asked.

“No, I’m good. Thank you.” You replied softly. With your head leaning against the headrest, you looked out the window. The only reason you would be out this late usually was because you were working.

“Thanks for dropping me off again.” You said as Taehyung pulled up outside of your house.

“Any time.” Taehyung smiled. You unbluckled your seatbelt and got out of the car. But before you could walk further, Taehyung rolled down the window.

“Goodnight, (y/n)!”

“G-Goodnight, Taehyung sshi.” A small smile formed on your lips as you bowed your head and entered the house. Like the other day, Taehyung only drove off after he was sure you had entered the house.

Only after you entered the house and you heard Taehyung drive off, that you realised you had forgotten the return him his jacket. You removed it carefully, as if any movement would cause it to tear like tissue. You inspected it, trying to figure out if you should wash it on your own, and risk ruining the expensive material, or just send it for dry cleaning.

“Hi, Wonwoo. Did you make it home safe?”

“Oh, (y/n). Yes, I am home. I went home after you sent me that text. Are you alright? You scared me.”

“Yes, I am alright. I just found a quiet space to chill for a while so I didn’t want you to wait for me. I just got home. Sorry for ruining the night. I’ll make it up to you, I promise.” You said, putting your shoes away.

“Don’t say that, (y/n). I’m sorry you didn’t enjoy yourself.”

“I did enjoy myself, Wonwoo. Thank you for bringing me out to feel better.” You laughed. After wishing each other good night, you hung up.

You took a shower and was feeling peckish so you made yourself some ramyeon. There was always ramyeon in the kitchen for when you or your mother needed a late night snack after working.

“I’ll have to drop the jacket off at the dry cleaners tomorrow.” You groaned tiredly, looking at the blazer that rested over the back of the chair.

Hoseok was one of the first ones to wake up. After a day of working and a night of drinking, the boys all usually slept in during the weekends. The moment his foot touched the bottom of the stairs, a maid ran over to him, bowing her head in fear.

“What is it?” He raised an eyebrow.

“Your workers are here, sir. They said that it is important for you to see them immediately.” She relayed timidly, afraid of making him angry.

“Send them in. And get my breakfast.” Hoseok shooed her away before shuffling to the dining room. Like any other normal person, he didn’t like having to work on the weekends.

“Good morning, Boss.” The 3 men put the crate that they were carrying down and bowed to Hoseok.

“This better be important for you to be here on a Saturday morning.” Hoseok said, not even looking up at them. He was more focused on the tray of food that the butler had placed down in front of him.

“The shipment is here early. We thought you would want to check it right away.” One of the men informed. Hoseok put his napkin on the table and stood up.

“Show me.” He commanded as he walked over. The men opened the box, revealing the contents inside.

“Very nice...” He picked up one of the items.

“Business on a Saturday morning, Hobah?” Yoongi came in. Hoseok’s workers bowed upon seeing the pale man enter the dining room. But of course, he didn’t even spare them a glance. He sat down in his allocated seat, waiting for the staff to serve him his breakfast. His breakfast was usually an iced coffee then his food 20 minutes later.

“Can’t help it, hyung. You want the best, you’ve got to work when others aren’t.” Hoseok laughed while Yoongi snorted at his comment. He placed the items back into the crate.

“Leave this here. I’ll show the others to see what they think. Good work. We’ll discuss the rest on Monday.” Hoseok said.

“Of course, boss. Have a nice weekend.” The 3 bowed, moving the crate to the side of the room before leaving the mansion. Hoseok took his seat across Yoongi.

“So hyung, I heard you had a little moment with the girl.” Hoseok asked.

“What moment?” Yoongi asked back, no emotion on his face as he sipped the last bit of his coffee.

“Jimin said you loyally guarded the door for her as she used our toilet. Even stayed with her in the hallway after to comfort her.” He explained. Yoongi rolled his eyes, his brothers really needed better things to talk about.

“I saw her the moment she entered, I’m surprised you guys didn’t considering how high our booth is. She needed to use a toilet and the queue was insane so I offered her to use ours. And I wasn’t comforting her, she needed a quiet place and I stayed with her. That’s all.” Yoongi explained.

“Well, that’s a lot more interaction than what the rest have got. Looks like she’ll warm up to you first.” Hoseok said.

“No, she’ll warm up to Taehyung first. He was the one that sent her home.” Yoongi dug into his food on the tray that the butler brought him. Hoseok hummed but couldn’t help the giggle that escaped him.

“What’s Hobi laughing about?” Namjoon came in. He had been awake for a while, opting to sit in his room to read the newspaper rather than come downstairs right away.

“No idea.” Yoongi replied, putting a chopstick of rice into his mouth.

“Ah, seriously, Hobi. I thought we established that we are not going to bring work into the dining room?” Namjoon tsked at the crate in the room.

“It’s fine, Namjoon ah. I’ll move it after breakfast. The boys needed me to inspect the goods, that’s all. Even risked bothering me on a Saturday to do it.” Hoseok waved the leader off. Namjoon shook his head with a sigh.

“Bring my breakfast.” He ordered as he took his seat at the head of the table. The butler bowed and left.

“I’m done. Going back to sleep.” Yoongi stood up and shuffled out of the room. The weekend was for Yoongi to catch up on sleep, it was normal to not see him for the entirety of the two days because he was just sleeping or resting in bed. Jin and Taehyung were the last ones that had breakfast. Jungkook and Jimin would sleep in until dinner time.

“Here. Take what is yours and leave the rest. I told you I would get things done.” Jin dropped the stack of files on the table. Namjoon, Hoseok and Taehyung shrugged, going through the pile to retrieve their things.

“So, hyung, did you find out anymore information about (y/n) when you did your stalking?” Taehyung asked.

“Yah, Taehyung! That was supposed to be confidential.” Jin hissed at the younger exposing him to the rest. However, the younger just shrugged.

“You’re running a check on her?” Namjoon raised an eyebrow.

“I’m not running a check on her... Well, at least not the background checks I usually do. I just wanted to find out about her to maybe try to connect with her in some way. She is a closed book.” Jin explained.

“So what if she is a closed book, I’m sure you can still find whatever you need on her.” Hosoek laughed.

“That’s the thing... She does not have much of a record except for her birth certificate and basic school details. Everything else either doesn’t exist or has been wiped.” Jin informed.

“Wait, you’re telling me there is actually information that you can’t find?”

“How do you know information has been wiped? She could have just not had that much of an eventful life so far. I doubt she can wipe her own records and she doesn’t seem to have a reason to do that.” Namjoon said. He didn’t know you but you didn’t seem like a skillful hacker that could wipe records.

“I know information has been wiped because I am the one who wiped them...” Jin admitted with his head slightly hung.

“What?”

“Boss wanted me to wipe them. He was paranoid, especially when it came to her. So my task was to regularly wipe her records that were 'not relevant’. Hospital visits, stuff like that...” Jin gulped.

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